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Application of Volumetric Modulated Arc Therapy and Simultaneous Integrated Boost Techniques to Prepare "Safe Margin" in the Rabbit VX2 Limb Tumor Model.

Wang CW, Zhou Y, Bai JP, Liu H, Liu Y, Shi GL, Ding JJ, Ma DH, Li WT, Xie PM, Yan Y - Med. Sci. Monit. (2015)

Bottom Line: After radiotherapy, the two groups showed a significant difference in the GTVboost area.The 3D-PDA observation showed that tumor vascular structures decreased significantly.The formation of a necrotic zone can be effectively defined as safe margin in the GTVboost area. showing potential clinical applicability.

View Article: PubMed Central - PubMed

Affiliation: Department of Bone and Soft Tissue, The Affiliated Tumor Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China (mainland).

ABSTRACT

Background: In this study, we aimed to establish the rabbit VX2 limb tumor model, and then prepare a "necrotic zone" as a safe margin by volumetric modulated arc therapy and simultaneous integrated boost (VMAT-SIB) technique applied in the areas where the tumor is located adjacent to the bone (GTVboost area).

Material and methods: Rabbits in the control group (n=10) were not treated, while those in the test group (n=10) were treated with the SIB schedule delivering a dose of 40Gy, 35Gy, 30Gy, and 25Gy to the GTVboost, GTV (gross tumor volume), CTV (clinical target volume), and PTV (planning target volume) in 10 fractions. Magnetic resonance diffusion-weighted imaging (MRDWI), 3-dimensional power Doppler angiography (3D-PDA), and histological changes were observed after radiotherapy.

Results: After radiotherapy, the two groups showed a significant difference in the GTVboost area. In the test group, the tumor necrosis showed a significantly low signal in DWI and high signal in apparent diffusion coefficient (ADC) maps. The 3D-PDA observation showed that tumor vascular structures decreased significantly. Histological analysis demonstrated that a necrotic zone could be generated in the GTVboost area, and microscopic examination observed cell necrosis and fibroplasia.

Conclusions: This studies demonstrated the feasibility of using VMAT-SIB technique in the rabbit VX2 limb tumor model. The formation of a necrotic zone can be effectively defined as safe margin in the GTVboost area. showing potential clinical applicability.

No MeSH data available.


Related in: MedlinePlus

Signal intensity of GTVboost area in DWI and ADC maps after radiotherapy. In the control group, the GTVboost area showed a significantly high signal in DWI (A) and low signal in ADC maps (B). For the test group, the GTVboost area showed a significantly low signal in DWI (C) and high signal in ADC maps (D). Green arrow: femur. Red arrow: GTVboost area (areas where tumor was located adjacent to the bone).
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f3-medscimonit-21-2397: Signal intensity of GTVboost area in DWI and ADC maps after radiotherapy. In the control group, the GTVboost area showed a significantly high signal in DWI (A) and low signal in ADC maps (B). For the test group, the GTVboost area showed a significantly low signal in DWI (C) and high signal in ADC maps (D). Green arrow: femur. Red arrow: GTVboost area (areas where tumor was located adjacent to the bone).

Mentions: The control group displayed relatively long signal on axial T1WI and showed heterogeneous high signal on axial T2WI. The GTVboost area showed a significantly high signal in DWI (Figure 3A) and low signal in ADC maps (Figure 3B). The test group displayed relatively high signal on axial T1WI and showed a significantly high signal on T2WI. The GTVboost area showed a significantly low signal in DWI (Figure 3C) and high signal in ADC maps (Figure 3D).The ADC value of test group(2.41±0.09×10−3 mm2/s) was significantly higher than control group (1.55±0.06×10−3 mm2/s) (Figure 4).


Application of Volumetric Modulated Arc Therapy and Simultaneous Integrated Boost Techniques to Prepare "Safe Margin" in the Rabbit VX2 Limb Tumor Model.

Wang CW, Zhou Y, Bai JP, Liu H, Liu Y, Shi GL, Ding JJ, Ma DH, Li WT, Xie PM, Yan Y - Med. Sci. Monit. (2015)

Signal intensity of GTVboost area in DWI and ADC maps after radiotherapy. In the control group, the GTVboost area showed a significantly high signal in DWI (A) and low signal in ADC maps (B). For the test group, the GTVboost area showed a significantly low signal in DWI (C) and high signal in ADC maps (D). Green arrow: femur. Red arrow: GTVboost area (areas where tumor was located adjacent to the bone).
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Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4544349&req=5

f3-medscimonit-21-2397: Signal intensity of GTVboost area in DWI and ADC maps after radiotherapy. In the control group, the GTVboost area showed a significantly high signal in DWI (A) and low signal in ADC maps (B). For the test group, the GTVboost area showed a significantly low signal in DWI (C) and high signal in ADC maps (D). Green arrow: femur. Red arrow: GTVboost area (areas where tumor was located adjacent to the bone).
Mentions: The control group displayed relatively long signal on axial T1WI and showed heterogeneous high signal on axial T2WI. The GTVboost area showed a significantly high signal in DWI (Figure 3A) and low signal in ADC maps (Figure 3B). The test group displayed relatively high signal on axial T1WI and showed a significantly high signal on T2WI. The GTVboost area showed a significantly low signal in DWI (Figure 3C) and high signal in ADC maps (Figure 3D).The ADC value of test group(2.41±0.09×10−3 mm2/s) was significantly higher than control group (1.55±0.06×10−3 mm2/s) (Figure 4).

Bottom Line: After radiotherapy, the two groups showed a significant difference in the GTVboost area.The 3D-PDA observation showed that tumor vascular structures decreased significantly.The formation of a necrotic zone can be effectively defined as safe margin in the GTVboost area. showing potential clinical applicability.

View Article: PubMed Central - PubMed

Affiliation: Department of Bone and Soft Tissue, The Affiliated Tumor Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China (mainland).

ABSTRACT

Background: In this study, we aimed to establish the rabbit VX2 limb tumor model, and then prepare a "necrotic zone" as a safe margin by volumetric modulated arc therapy and simultaneous integrated boost (VMAT-SIB) technique applied in the areas where the tumor is located adjacent to the bone (GTVboost area).

Material and methods: Rabbits in the control group (n=10) were not treated, while those in the test group (n=10) were treated with the SIB schedule delivering a dose of 40Gy, 35Gy, 30Gy, and 25Gy to the GTVboost, GTV (gross tumor volume), CTV (clinical target volume), and PTV (planning target volume) in 10 fractions. Magnetic resonance diffusion-weighted imaging (MRDWI), 3-dimensional power Doppler angiography (3D-PDA), and histological changes were observed after radiotherapy.

Results: After radiotherapy, the two groups showed a significant difference in the GTVboost area. In the test group, the tumor necrosis showed a significantly low signal in DWI and high signal in apparent diffusion coefficient (ADC) maps. The 3D-PDA observation showed that tumor vascular structures decreased significantly. Histological analysis demonstrated that a necrotic zone could be generated in the GTVboost area, and microscopic examination observed cell necrosis and fibroplasia.

Conclusions: This studies demonstrated the feasibility of using VMAT-SIB technique in the rabbit VX2 limb tumor model. The formation of a necrotic zone can be effectively defined as safe margin in the GTVboost area. showing potential clinical applicability.

No MeSH data available.


Related in: MedlinePlus