Limits...
An assessment of chemotherapy-induced nausea and vomiting direct costs in three EU countries.

Turini M, Piovesana V, Ruffo P, Ripellino C, Cataldo N - Drugs Context (2015)

Bottom Line: There are many reports on the cost-effectiveness of antiemetic drugs, but information on the total cost per patient associated with CINV is limited.The costs associated with severe CINV episodes are considered responsible for the most significant part of the expenditures.In Italy, the mean cost per patient with a severe CINV episode resulted in approximately €389, about half of the mean cost in France (€750) and a third of the mean cost in Germany (€1,017).

View Article: PubMed Central - PubMed

Affiliation: Helsinn Healthcare SA, Lugano/Pazzallo, Switzerland;

ABSTRACT

Background: chemotherapy-induced nausea and vomiting (CINV) has been commonly reported as one of the most distressing adverse effects among treated patients with cancer. Inadequately treated, CINV can lead to increased resource utilization and severely impair patients' daily functioning and quality of life. Direct costs include acquisition cost of antiemetic drugs and rescue medication, administration devices, add-on treatments, such as hydration, and additional patient care, that is, nursing and physician time, unscheduled office visits, emergency room admissions, and, in some cases, extended hospitalization or readmission. There are many reports on the cost-effectiveness of antiemetic drugs, but information on the total cost per patient associated with CINV is limited. The costs associated with severe CINV episodes are considered responsible for the most significant part of the expenditures.

Scope: The aim of this study was to investigate the management of CINV episodes in three European health-care environments and to estimate direct costs associated with severe CINV episodes.

Methods: An online survey addressed to Italian, German, and French oncologists and oncology nurses was performed. The survey included 41 questions about the management and the resource utilization for patients experiencing any CINV episode during the 6-month period preceding the survey. Furthermore, the cost associated with severe CINV episode management was estimated by adopting the National Health Service's perspective.

Findings: A large proportion of patients receiving chemotherapy experienced a CINV episode (34.4% in Italy, 50.2% in France, and 40.4% in Germany); among those, 8.8% in Italy, 11.6% in France, and 19.2% in Germany experienced a severe CINV episode. Compared with Italy, Germany and France presented a greater hospitalization rate following an unplanned visit to the oncology ward or an emergency room access due to CINV. In Italy, the mean cost per patient with a severe CINV episode resulted in approximately €389, about half of the mean cost in France (€750) and a third of the mean cost in Germany (€1,017).

Conclusions: Severe CINV episodes requiring hospitalization, day hospital, or hospitalization extension involve a significant cost for the National Health Services; additional studies should be conducted in order to evaluate potential ways to offset these expenses.

No MeSH data available.


Related in: MedlinePlus

Flowchart: focus on patients with severe CINV episode.
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Related In: Results  -  Collection


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f2-dic-4-212285: Flowchart: focus on patients with severe CINV episode.

Mentions: Figure 2 illustrates the flowchart that defines the subgroup of patients who experienced a severe CINV episode. The highest proportion of patients with a severe CINV episode was found in Germany (19.2%), followed by France and Italy (11.6% and 8.8% of CINV patients, respectively). Resource utilization in the management of severe CINV episodes confirmed a greater tendency to hospitalize patients in Germany and in France than in Italy (Table 4).


An assessment of chemotherapy-induced nausea and vomiting direct costs in three EU countries.

Turini M, Piovesana V, Ruffo P, Ripellino C, Cataldo N - Drugs Context (2015)

Flowchart: focus on patients with severe CINV episode.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4544273&req=5

f2-dic-4-212285: Flowchart: focus on patients with severe CINV episode.
Mentions: Figure 2 illustrates the flowchart that defines the subgroup of patients who experienced a severe CINV episode. The highest proportion of patients with a severe CINV episode was found in Germany (19.2%), followed by France and Italy (11.6% and 8.8% of CINV patients, respectively). Resource utilization in the management of severe CINV episodes confirmed a greater tendency to hospitalize patients in Germany and in France than in Italy (Table 4).

Bottom Line: There are many reports on the cost-effectiveness of antiemetic drugs, but information on the total cost per patient associated with CINV is limited.The costs associated with severe CINV episodes are considered responsible for the most significant part of the expenditures.In Italy, the mean cost per patient with a severe CINV episode resulted in approximately €389, about half of the mean cost in France (€750) and a third of the mean cost in Germany (€1,017).

View Article: PubMed Central - PubMed

Affiliation: Helsinn Healthcare SA, Lugano/Pazzallo, Switzerland;

ABSTRACT

Background: chemotherapy-induced nausea and vomiting (CINV) has been commonly reported as one of the most distressing adverse effects among treated patients with cancer. Inadequately treated, CINV can lead to increased resource utilization and severely impair patients' daily functioning and quality of life. Direct costs include acquisition cost of antiemetic drugs and rescue medication, administration devices, add-on treatments, such as hydration, and additional patient care, that is, nursing and physician time, unscheduled office visits, emergency room admissions, and, in some cases, extended hospitalization or readmission. There are many reports on the cost-effectiveness of antiemetic drugs, but information on the total cost per patient associated with CINV is limited. The costs associated with severe CINV episodes are considered responsible for the most significant part of the expenditures.

Scope: The aim of this study was to investigate the management of CINV episodes in three European health-care environments and to estimate direct costs associated with severe CINV episodes.

Methods: An online survey addressed to Italian, German, and French oncologists and oncology nurses was performed. The survey included 41 questions about the management and the resource utilization for patients experiencing any CINV episode during the 6-month period preceding the survey. Furthermore, the cost associated with severe CINV episode management was estimated by adopting the National Health Service's perspective.

Findings: A large proportion of patients receiving chemotherapy experienced a CINV episode (34.4% in Italy, 50.2% in France, and 40.4% in Germany); among those, 8.8% in Italy, 11.6% in France, and 19.2% in Germany experienced a severe CINV episode. Compared with Italy, Germany and France presented a greater hospitalization rate following an unplanned visit to the oncology ward or an emergency room access due to CINV. In Italy, the mean cost per patient with a severe CINV episode resulted in approximately €389, about half of the mean cost in France (€750) and a third of the mean cost in Germany (€1,017).

Conclusions: Severe CINV episodes requiring hospitalization, day hospital, or hospitalization extension involve a significant cost for the National Health Services; additional studies should be conducted in order to evaluate potential ways to offset these expenses.

No MeSH data available.


Related in: MedlinePlus