Limits...
TUBERCULOSIS INFECTION MIGHT INCREASE THE RISK OF INVASIVE CANDIDIASIS IN AN IMMUNOCOMPETENT PATIENT.

Chen XH, Gao YC, Zhang Y, Tang ZH, Yu YS, Zang GQ - Rev. Inst. Med. Trop. Sao Paulo (2015 May-Jun)

Bottom Line: The 19-year-old man complained of month-long fever and lower back pain.He also had a history of scalded mouth syndrome.Symptoms improved considerably after antifungal and antituberculous therapy.

View Article: PubMed Central - PubMed

Affiliation: Department of Infectious Diseases, Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, China.

ABSTRACT
Deep Candida infections commonly occur in immunosuppressed patients. A rare case of a multiple deep organ infection with Candida albicans and spinal tuberculosis was reported in a healthy young man. The 19-year-old man complained of month-long fever and lower back pain. He also had a history of scalded mouth syndrome. Coinfection with Mycobacterium tuberculosis and Candida albicans was diagnosed using the culture of aspirates from different regions. Symptoms improved considerably after antifungal and antituberculous therapy. This case illustrates that infection with tuberculosis might impair the host's immune system and increase the risk of invasive candidiasis in an immunocompetent patient.

Show MeSH

Related in: MedlinePlus

A. MRI showing altered signal intensity in T11, T12, L1 and uniqueosteolytic lesions in the above vertebral bodies (arrow). B, C.Histopathologic examination of aspirates showing caseous material and acid fastbacilli (arrow), respectively.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4544255&req=5

f02: A. MRI showing altered signal intensity in T11, T12, L1 and uniqueosteolytic lesions in the above vertebral bodies (arrow). B, C.Histopathologic examination of aspirates showing caseous material and acid fastbacilli (arrow), respectively.

Mentions: However, there was no improvement in the patient's lower back pain. Spinal magneticresonance imaging (MRI) showed altered signal intensity in T11, T12, L1 and uniqueosteolytic lesions in upper vertebral bodies (Fig.2A). Subsequently, computed tomography (CT) guided percutaneous vertebralbiopsy specimens from the T12 vertebrae revealed caseous material and the acid fastbacilli were identified (Fig.2B, C). Also, the aspirate culture showed growth of theM. tuberculosis. Chest CT, urine and sputum examinations werenormal. Taking histological and microbiological findings into consideration, the patientwas treated with antitubercular therapy (rifampicin, isoniazid, pyrazinamide,ethambutol) for 12 months. In addition, he was treated with a total dose of 1500 mg ofamphotericin B, while oral fluconazole and 5-flucytosine were subsequently prescribedfor six months. By his 2-year follow up, there were complete resolutions of the lesionsin the upper vertebral bodies and no evidence of new abscesses.


TUBERCULOSIS INFECTION MIGHT INCREASE THE RISK OF INVASIVE CANDIDIASIS IN AN IMMUNOCOMPETENT PATIENT.

Chen XH, Gao YC, Zhang Y, Tang ZH, Yu YS, Zang GQ - Rev. Inst. Med. Trop. Sao Paulo (2015 May-Jun)

A. MRI showing altered signal intensity in T11, T12, L1 and uniqueosteolytic lesions in the above vertebral bodies (arrow). B, C.Histopathologic examination of aspirates showing caseous material and acid fastbacilli (arrow), respectively.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4544255&req=5

f02: A. MRI showing altered signal intensity in T11, T12, L1 and uniqueosteolytic lesions in the above vertebral bodies (arrow). B, C.Histopathologic examination of aspirates showing caseous material and acid fastbacilli (arrow), respectively.
Mentions: However, there was no improvement in the patient's lower back pain. Spinal magneticresonance imaging (MRI) showed altered signal intensity in T11, T12, L1 and uniqueosteolytic lesions in upper vertebral bodies (Fig.2A). Subsequently, computed tomography (CT) guided percutaneous vertebralbiopsy specimens from the T12 vertebrae revealed caseous material and the acid fastbacilli were identified (Fig.2B, C). Also, the aspirate culture showed growth of theM. tuberculosis. Chest CT, urine and sputum examinations werenormal. Taking histological and microbiological findings into consideration, the patientwas treated with antitubercular therapy (rifampicin, isoniazid, pyrazinamide,ethambutol) for 12 months. In addition, he was treated with a total dose of 1500 mg ofamphotericin B, while oral fluconazole and 5-flucytosine were subsequently prescribedfor six months. By his 2-year follow up, there were complete resolutions of the lesionsin the upper vertebral bodies and no evidence of new abscesses.

Bottom Line: The 19-year-old man complained of month-long fever and lower back pain.He also had a history of scalded mouth syndrome.Symptoms improved considerably after antifungal and antituberculous therapy.

View Article: PubMed Central - PubMed

Affiliation: Department of Infectious Diseases, Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, China.

ABSTRACT
Deep Candida infections commonly occur in immunosuppressed patients. A rare case of a multiple deep organ infection with Candida albicans and spinal tuberculosis was reported in a healthy young man. The 19-year-old man complained of month-long fever and lower back pain. He also had a history of scalded mouth syndrome. Coinfection with Mycobacterium tuberculosis and Candida albicans was diagnosed using the culture of aspirates from different regions. Symptoms improved considerably after antifungal and antituberculous therapy. This case illustrates that infection with tuberculosis might impair the host's immune system and increase the risk of invasive candidiasis in an immunocompetent patient.

Show MeSH
Related in: MedlinePlus