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Exercise-induced anaphylaxis and antileukotriene montelukast.

Gajbhiye S, Agrawal RP, Atal S, Tiwari V, Phadnis P - J Pharmacol Pharmacother (2015 Jul-Sep)

Bottom Line: We report a rare case of exercise-induced anaphylaxis (EIA), occurring exclusively with exercise, without any other associated trigger, detected in the prodromal phase, and prevented from additional anaphylaxis episodes by treatment with cetirizine and 10 mg daily of antileukotriene montelukast to date.EIA is a syndrome in which patients experience a spectrum of the symptoms of anaphylaxis ranging from mild cutaneous signs to severe systemic manifestations such as hypotension, syncope, and even death after increased physical activity.It is differentiated from cholinergic urticaria by the absence of response to passive body warming and emotional stress.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology, Mahatma Gandhi Memorial Medical College, Indore, Madhya Pradesh, India.

ABSTRACT
We report a rare case of exercise-induced anaphylaxis (EIA), occurring exclusively with exercise, without any other associated trigger, detected in the prodromal phase, and prevented from additional anaphylaxis episodes by treatment with cetirizine and 10 mg daily of antileukotriene montelukast to date. EIA is a syndrome in which patients experience a spectrum of the symptoms of anaphylaxis ranging from mild cutaneous signs to severe systemic manifestations such as hypotension, syncope, and even death after increased physical activity. Many people have triggers, such as, a variety of foods, various medications, alcohol, cold weather, humidity, and seasonal and hormonal changes along with exercise that cause the symptoms. Typically, either exercise or the specific trigger alone will rarely cause symptoms. It is differentiated from cholinergic urticaria by the absence of response to passive body warming and emotional stress.

No MeSH data available.


Related in: MedlinePlus

Pruritic skin lesions with angioedema of the eyelids after 12 hours
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Figure 1: Pruritic skin lesions with angioedema of the eyelids after 12 hours

Mentions: A 26-year-old male presented with a three-year history of exercise-associated rash. Every time, almost 30 minutes after starting to exercise; he felt warm and developed pruritus, flushing, and angioedema of the eyelid. Soon pruritic skin lesions developed, which started on his face and quickly increased in both number and size and became generalized, with development of urticaria. He started having a headache simultaneously. The patient immediately discontinued physical exercise at the first sign of pruritus and malaise, and therefore, the symptoms did not progress, but persisted till he was medicated [Figure 1].


Exercise-induced anaphylaxis and antileukotriene montelukast.

Gajbhiye S, Agrawal RP, Atal S, Tiwari V, Phadnis P - J Pharmacol Pharmacother (2015 Jul-Sep)

Pruritic skin lesions with angioedema of the eyelids after 12 hours
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4544140&req=5

Figure 1: Pruritic skin lesions with angioedema of the eyelids after 12 hours
Mentions: A 26-year-old male presented with a three-year history of exercise-associated rash. Every time, almost 30 minutes after starting to exercise; he felt warm and developed pruritus, flushing, and angioedema of the eyelid. Soon pruritic skin lesions developed, which started on his face and quickly increased in both number and size and became generalized, with development of urticaria. He started having a headache simultaneously. The patient immediately discontinued physical exercise at the first sign of pruritus and malaise, and therefore, the symptoms did not progress, but persisted till he was medicated [Figure 1].

Bottom Line: We report a rare case of exercise-induced anaphylaxis (EIA), occurring exclusively with exercise, without any other associated trigger, detected in the prodromal phase, and prevented from additional anaphylaxis episodes by treatment with cetirizine and 10 mg daily of antileukotriene montelukast to date.EIA is a syndrome in which patients experience a spectrum of the symptoms of anaphylaxis ranging from mild cutaneous signs to severe systemic manifestations such as hypotension, syncope, and even death after increased physical activity.It is differentiated from cholinergic urticaria by the absence of response to passive body warming and emotional stress.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology, Mahatma Gandhi Memorial Medical College, Indore, Madhya Pradesh, India.

ABSTRACT
We report a rare case of exercise-induced anaphylaxis (EIA), occurring exclusively with exercise, without any other associated trigger, detected in the prodromal phase, and prevented from additional anaphylaxis episodes by treatment with cetirizine and 10 mg daily of antileukotriene montelukast to date. EIA is a syndrome in which patients experience a spectrum of the symptoms of anaphylaxis ranging from mild cutaneous signs to severe systemic manifestations such as hypotension, syncope, and even death after increased physical activity. Many people have triggers, such as, a variety of foods, various medications, alcohol, cold weather, humidity, and seasonal and hormonal changes along with exercise that cause the symptoms. Typically, either exercise or the specific trigger alone will rarely cause symptoms. It is differentiated from cholinergic urticaria by the absence of response to passive body warming and emotional stress.

No MeSH data available.


Related in: MedlinePlus