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Effectiveness of vitamin D3 in severe persistent asthmatic patients: A double blind, randomized, clinical study.

Rajanandh MG, Nageswari AD, Prathiksha G - J Pharmacol Pharmacother (2015 Jul-Sep)

Bottom Line: In terms of health-related quality of life, within-group comparison revealed a significant (P < 0.05) improvement in all the domains of SGRQ.However, between-group comparisons showed statistically significant (P < 0.05) improvement in symptom, impact and total scores.On the basis of our findings, we conclude that supplementation of vitamin D3 is effective in improving the quality of life rather than pulmonary function in severe asthmatics.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacy Practice, Faculty of Pharmacy, Sri Ramachandra University, Porur, Chennai, Tamil Nadu, India.

ABSTRACT

Objective: To assess the pulmonary function and quality of life in asthma patients receiving vitamin D3 supplementation with inhaled budesonide and formoterol.

Materials and methods: This was a double blinded, randomized, comparative study. Patients were recruited as per the study criteria and randomized into two groups: usual care group (n = 69) patients received budesonide (800 μg) with formoterol (24 μg) and intervention care group (n = 72) patients received vitamin D3 (1000 IU) supplementation along with budesonide (800 μg) plus formoterol (24 μg) for a period of 6 months.

Results: A total of 140 patients completed the study. Significant within-group improvement and non-significant between-group improvement is observed with respect to FEV1. In terms of health-related quality of life, within-group comparison revealed a significant (P < 0.05) improvement in all the domains of SGRQ. However, between-group comparisons showed statistically significant (P < 0.05) improvement in symptom, impact and total scores.

Conclusion: On the basis of our findings, we conclude that supplementation of vitamin D3 is effective in improving the quality of life rather than pulmonary function in severe asthmatics. However, further studies are warranted to substantiate the present findings.

No MeSH data available.


Related in: MedlinePlus

Visit-wise change in SGRQ scores within the study groups
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Figure 3: Visit-wise change in SGRQ scores within the study groups

Mentions: Statistically significant improvement is observed in symptom score, activity score, impact score and total scores of SGRQ in within-group comparison [Figure 3]. With respect to symptom score, between-group comparison showed statistically significant improvement (P < 0.001) from day 30 onward. However, no significant difference was observed between the groups in terms of activity scores. Regarding impact score, a statistically significant difference was observed from day 30 till the end of final follow-up. Between-group comparison of total score has shown no statistically significant improvement from the baseline to day 150. However, on the final follow-up day, a statistically significant improvement (P < 0.05) was observed [Table 3].


Effectiveness of vitamin D3 in severe persistent asthmatic patients: A double blind, randomized, clinical study.

Rajanandh MG, Nageswari AD, Prathiksha G - J Pharmacol Pharmacother (2015 Jul-Sep)

Visit-wise change in SGRQ scores within the study groups
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4544135&req=5

Figure 3: Visit-wise change in SGRQ scores within the study groups
Mentions: Statistically significant improvement is observed in symptom score, activity score, impact score and total scores of SGRQ in within-group comparison [Figure 3]. With respect to symptom score, between-group comparison showed statistically significant improvement (P < 0.001) from day 30 onward. However, no significant difference was observed between the groups in terms of activity scores. Regarding impact score, a statistically significant difference was observed from day 30 till the end of final follow-up. Between-group comparison of total score has shown no statistically significant improvement from the baseline to day 150. However, on the final follow-up day, a statistically significant improvement (P < 0.05) was observed [Table 3].

Bottom Line: In terms of health-related quality of life, within-group comparison revealed a significant (P < 0.05) improvement in all the domains of SGRQ.However, between-group comparisons showed statistically significant (P < 0.05) improvement in symptom, impact and total scores.On the basis of our findings, we conclude that supplementation of vitamin D3 is effective in improving the quality of life rather than pulmonary function in severe asthmatics.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacy Practice, Faculty of Pharmacy, Sri Ramachandra University, Porur, Chennai, Tamil Nadu, India.

ABSTRACT

Objective: To assess the pulmonary function and quality of life in asthma patients receiving vitamin D3 supplementation with inhaled budesonide and formoterol.

Materials and methods: This was a double blinded, randomized, comparative study. Patients were recruited as per the study criteria and randomized into two groups: usual care group (n = 69) patients received budesonide (800 μg) with formoterol (24 μg) and intervention care group (n = 72) patients received vitamin D3 (1000 IU) supplementation along with budesonide (800 μg) plus formoterol (24 μg) for a period of 6 months.

Results: A total of 140 patients completed the study. Significant within-group improvement and non-significant between-group improvement is observed with respect to FEV1. In terms of health-related quality of life, within-group comparison revealed a significant (P < 0.05) improvement in all the domains of SGRQ. However, between-group comparisons showed statistically significant (P < 0.05) improvement in symptom, impact and total scores.

Conclusion: On the basis of our findings, we conclude that supplementation of vitamin D3 is effective in improving the quality of life rather than pulmonary function in severe asthmatics. However, further studies are warranted to substantiate the present findings.

No MeSH data available.


Related in: MedlinePlus