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Effectiveness of vitamin D3 in severe persistent asthmatic patients: A double blind, randomized, clinical study.

Rajanandh MG, Nageswari AD, Prathiksha G - J Pharmacol Pharmacother (2015 Jul-Sep)

Bottom Line: In terms of health-related quality of life, within-group comparison revealed a significant (P < 0.05) improvement in all the domains of SGRQ.However, between-group comparisons showed statistically significant (P < 0.05) improvement in symptom, impact and total scores.On the basis of our findings, we conclude that supplementation of vitamin D3 is effective in improving the quality of life rather than pulmonary function in severe asthmatics.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacy Practice, Faculty of Pharmacy, Sri Ramachandra University, Porur, Chennai, Tamil Nadu, India.

ABSTRACT

Objective: To assess the pulmonary function and quality of life in asthma patients receiving vitamin D3 supplementation with inhaled budesonide and formoterol.

Materials and methods: This was a double blinded, randomized, comparative study. Patients were recruited as per the study criteria and randomized into two groups: usual care group (n = 69) patients received budesonide (800 μg) with formoterol (24 μg) and intervention care group (n = 72) patients received vitamin D3 (1000 IU) supplementation along with budesonide (800 μg) plus formoterol (24 μg) for a period of 6 months.

Results: A total of 140 patients completed the study. Significant within-group improvement and non-significant between-group improvement is observed with respect to FEV1. In terms of health-related quality of life, within-group comparison revealed a significant (P < 0.05) improvement in all the domains of SGRQ. However, between-group comparisons showed statistically significant (P < 0.05) improvement in symptom, impact and total scores.

Conclusion: On the basis of our findings, we conclude that supplementation of vitamin D3 is effective in improving the quality of life rather than pulmonary function in severe asthmatics. However, further studies are warranted to substantiate the present findings.

No MeSH data available.


Related in: MedlinePlus

Flow of patients and CONSORT diagram
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Figure 1: Flow of patients and CONSORT diagram

Mentions: The study was conducted between June 2013 and April 2014. A total of 172 patients attended the screening phase for severe persistent asthma condition, out of which 161 patients met the study criteria. In the usual care group, out of 79 patients, 69 patients completed the study and in the intervention care group, out of 82 patients, 72 patients completed the study. Reasons for drop out in both the groups are mentioned in Figure 1. Baseline characteristics, including age, gender, education and BMI are given in Table 1. There were no significant differences in baseline characteristics among the groups (P > 0.05).


Effectiveness of vitamin D3 in severe persistent asthmatic patients: A double blind, randomized, clinical study.

Rajanandh MG, Nageswari AD, Prathiksha G - J Pharmacol Pharmacother (2015 Jul-Sep)

Flow of patients and CONSORT diagram
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4544135&req=5

Figure 1: Flow of patients and CONSORT diagram
Mentions: The study was conducted between June 2013 and April 2014. A total of 172 patients attended the screening phase for severe persistent asthma condition, out of which 161 patients met the study criteria. In the usual care group, out of 79 patients, 69 patients completed the study and in the intervention care group, out of 82 patients, 72 patients completed the study. Reasons for drop out in both the groups are mentioned in Figure 1. Baseline characteristics, including age, gender, education and BMI are given in Table 1. There were no significant differences in baseline characteristics among the groups (P > 0.05).

Bottom Line: In terms of health-related quality of life, within-group comparison revealed a significant (P < 0.05) improvement in all the domains of SGRQ.However, between-group comparisons showed statistically significant (P < 0.05) improvement in symptom, impact and total scores.On the basis of our findings, we conclude that supplementation of vitamin D3 is effective in improving the quality of life rather than pulmonary function in severe asthmatics.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacy Practice, Faculty of Pharmacy, Sri Ramachandra University, Porur, Chennai, Tamil Nadu, India.

ABSTRACT

Objective: To assess the pulmonary function and quality of life in asthma patients receiving vitamin D3 supplementation with inhaled budesonide and formoterol.

Materials and methods: This was a double blinded, randomized, comparative study. Patients were recruited as per the study criteria and randomized into two groups: usual care group (n = 69) patients received budesonide (800 μg) with formoterol (24 μg) and intervention care group (n = 72) patients received vitamin D3 (1000 IU) supplementation along with budesonide (800 μg) plus formoterol (24 μg) for a period of 6 months.

Results: A total of 140 patients completed the study. Significant within-group improvement and non-significant between-group improvement is observed with respect to FEV1. In terms of health-related quality of life, within-group comparison revealed a significant (P < 0.05) improvement in all the domains of SGRQ. However, between-group comparisons showed statistically significant (P < 0.05) improvement in symptom, impact and total scores.

Conclusion: On the basis of our findings, we conclude that supplementation of vitamin D3 is effective in improving the quality of life rather than pulmonary function in severe asthmatics. However, further studies are warranted to substantiate the present findings.

No MeSH data available.


Related in: MedlinePlus