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Inhaled insulin: A "puff" than a "shot" before meals.

Brashier DB, Khadka A, Anantharamu T, Sharma AK, Gupta AK, Sharma S, Dahiya N - J Pharmacol Pharmacother (2015 Jul-Sep)

Bottom Line: The large surface area, good vascularization, immense capacity for solute exchange and ultra-thinness of the alveolar epithelium facilitates systemic delivery of insulin via pulmonary administration.Inhaled insulin has been recently approved by Food and Drug Administration (FDA).It is a novel, rapid-acting inhaled insulin with a pharmacokinetic profile that is different from all other insulin products and comparatively safer than the previous failed inhaled insulin (Exubera).

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology, Armed Forces Medical College, Pune, Maharashtra, India.

ABSTRACT
Diabetes is a metabolic disorder characterized by relative or absolute deficiency of insulin, resulting in hyperglycemia. The main treatment of diabetes relies on subcutaneous insulin administration by injection or continuous infusion to control glucose levels, besides oral hypoglycemic agents for type 2 diabetes. Novel routes of insulin administration are an area of research in the diabetes field as insulin injection therapy is burdensome and painful for many patients. Inhalational insulin is a potential alternative to subcutaneous insulin in the management of diabetes. The large surface area, good vascularization, immense capacity for solute exchange and ultra-thinness of the alveolar epithelium facilitates systemic delivery of insulin via pulmonary administration. Inhaled insulin has been recently approved by Food and Drug Administration (FDA). It is a novel, rapid-acting inhaled insulin with a pharmacokinetic profile that is different from all other insulin products and comparatively safer than the previous failed inhaled insulin (Exubera).

No MeSH data available.


Related in: MedlinePlus

Mealtime inhaled insulin (Afrezza) dose conversion table[20]
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Related In: Results  -  Collection

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Figure 4: Mealtime inhaled insulin (Afrezza) dose conversion table[20]

Mentions: Inhalational insulin is available in two strengths [Figures 1 and 2] in foil packages. One foil package consists of two blister cards and there are five strips per blister card. Each strip contains three cartridges. It is administered using a single inhalation per cartridge. Cartridge should be stored at 2-8°C (36-46°F).[1315181920] [Figures 2-4].


Inhaled insulin: A "puff" than a "shot" before meals.

Brashier DB, Khadka A, Anantharamu T, Sharma AK, Gupta AK, Sharma S, Dahiya N - J Pharmacol Pharmacother (2015 Jul-Sep)

Mealtime inhaled insulin (Afrezza) dose conversion table[20]
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4544132&req=5

Figure 4: Mealtime inhaled insulin (Afrezza) dose conversion table[20]
Mentions: Inhalational insulin is available in two strengths [Figures 1 and 2] in foil packages. One foil package consists of two blister cards and there are five strips per blister card. Each strip contains three cartridges. It is administered using a single inhalation per cartridge. Cartridge should be stored at 2-8°C (36-46°F).[1315181920] [Figures 2-4].

Bottom Line: The large surface area, good vascularization, immense capacity for solute exchange and ultra-thinness of the alveolar epithelium facilitates systemic delivery of insulin via pulmonary administration.Inhaled insulin has been recently approved by Food and Drug Administration (FDA).It is a novel, rapid-acting inhaled insulin with a pharmacokinetic profile that is different from all other insulin products and comparatively safer than the previous failed inhaled insulin (Exubera).

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology, Armed Forces Medical College, Pune, Maharashtra, India.

ABSTRACT
Diabetes is a metabolic disorder characterized by relative or absolute deficiency of insulin, resulting in hyperglycemia. The main treatment of diabetes relies on subcutaneous insulin administration by injection or continuous infusion to control glucose levels, besides oral hypoglycemic agents for type 2 diabetes. Novel routes of insulin administration are an area of research in the diabetes field as insulin injection therapy is burdensome and painful for many patients. Inhalational insulin is a potential alternative to subcutaneous insulin in the management of diabetes. The large surface area, good vascularization, immense capacity for solute exchange and ultra-thinness of the alveolar epithelium facilitates systemic delivery of insulin via pulmonary administration. Inhaled insulin has been recently approved by Food and Drug Administration (FDA). It is a novel, rapid-acting inhaled insulin with a pharmacokinetic profile that is different from all other insulin products and comparatively safer than the previous failed inhaled insulin (Exubera).

No MeSH data available.


Related in: MedlinePlus