Limits...
SIX1 overexpression in diffuse-type and grade III gastric tumors: Features that are associated with poor prognosis.

Emadi-Baygi M, Nikpour P, Emadi-Andani E - Adv Biomed Res (2015)

Bottom Line: SIX1 expression was decreased in tumoral samples.However, its expression increased significantly in diffuse-type gastric cancer.Of note, the difference was significant between grades I and III.

View Article: PubMed Central - PubMed

Affiliation: Department of Genetics, Research Institute of Biotechnology, Shahrekord University, Shahrekord, Iran.

ABSTRACT

Background: Gastric cancer is the second most common cancer worldwide. In Iran, the incidence of gastric cancer is well above the world average, and is the first common cancer in Iranian men and the third one in women. Located at chromosome 14q23, SIX1 is a homolog of the Drosophila 'sine oculis' (so) gene and is highly conserved in numerous species. In addition to the role of SIX1 in the development, its expression is frequently dysregulated in multiple cancers. This study aimed to evaluate the clinicopathological features of the expression of SIX1 gene in gastric adenocarcinoma.

Materials and methods: Thirty pairs of gastric tissue samples from patients with gastric adenocarcinoma were evaluated for SIX1 gene expression using quantitative real-time polymerase chain reaction. A paired t-test or one-way ANOVA with post hoc multiple comparisons were used to analyze the differences between groups. Statistical significance was defined as P ≤ 0.05.

Results: SIX1 expression was decreased in tumoral samples. However, its expression increased significantly in diffuse-type gastric cancer. Furthermore, there was a trend toward statistical significance in increasing SIX1 gene expression with higher grades. Of note, the difference was significant between grades I and III.

Conclusions: The results suggest that SIX1 gene expression might be used in the future as a potential biomarker to predict the outcome of the disease as diffuse-type and grade III of gastric tumors are associated with poor prognosis.

No MeSH data available.


Related in: MedlinePlus

The relative expression levels of SIX1 in tumoral versus non-tumoral gastric samples. Error bars represent standard error of mean (SEM)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4544127&req=5

Figure 1: The relative expression levels of SIX1 in tumoral versus non-tumoral gastric samples. Error bars represent standard error of mean (SEM)

Mentions: Relative quantitation of the expression levels of SIX1 in gastric adenocarcinomas showed that the relative levels of SIX1 transcripts were significantly decreased (around 1.5-fold, P value = 0.018) in cancerous tissues compared with adjacent non-cancerous tissues: 0.48 ± 0.03 versus 0.64 ± 0.06, respectively, as shown in Figure 1.


SIX1 overexpression in diffuse-type and grade III gastric tumors: Features that are associated with poor prognosis.

Emadi-Baygi M, Nikpour P, Emadi-Andani E - Adv Biomed Res (2015)

The relative expression levels of SIX1 in tumoral versus non-tumoral gastric samples. Error bars represent standard error of mean (SEM)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4544127&req=5

Figure 1: The relative expression levels of SIX1 in tumoral versus non-tumoral gastric samples. Error bars represent standard error of mean (SEM)
Mentions: Relative quantitation of the expression levels of SIX1 in gastric adenocarcinomas showed that the relative levels of SIX1 transcripts were significantly decreased (around 1.5-fold, P value = 0.018) in cancerous tissues compared with adjacent non-cancerous tissues: 0.48 ± 0.03 versus 0.64 ± 0.06, respectively, as shown in Figure 1.

Bottom Line: SIX1 expression was decreased in tumoral samples.However, its expression increased significantly in diffuse-type gastric cancer.Of note, the difference was significant between grades I and III.

View Article: PubMed Central - PubMed

Affiliation: Department of Genetics, Research Institute of Biotechnology, Shahrekord University, Shahrekord, Iran.

ABSTRACT

Background: Gastric cancer is the second most common cancer worldwide. In Iran, the incidence of gastric cancer is well above the world average, and is the first common cancer in Iranian men and the third one in women. Located at chromosome 14q23, SIX1 is a homolog of the Drosophila 'sine oculis' (so) gene and is highly conserved in numerous species. In addition to the role of SIX1 in the development, its expression is frequently dysregulated in multiple cancers. This study aimed to evaluate the clinicopathological features of the expression of SIX1 gene in gastric adenocarcinoma.

Materials and methods: Thirty pairs of gastric tissue samples from patients with gastric adenocarcinoma were evaluated for SIX1 gene expression using quantitative real-time polymerase chain reaction. A paired t-test or one-way ANOVA with post hoc multiple comparisons were used to analyze the differences between groups. Statistical significance was defined as P ≤ 0.05.

Results: SIX1 expression was decreased in tumoral samples. However, its expression increased significantly in diffuse-type gastric cancer. Furthermore, there was a trend toward statistical significance in increasing SIX1 gene expression with higher grades. Of note, the difference was significant between grades I and III.

Conclusions: The results suggest that SIX1 gene expression might be used in the future as a potential biomarker to predict the outcome of the disease as diffuse-type and grade III of gastric tumors are associated with poor prognosis.

No MeSH data available.


Related in: MedlinePlus