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Prevention of enamel demineralization with a novel fluoride strip: enamel surface composition and depth profile.

Lee BS, Chou PH, Chen SY, Liao HY, Chang CC - Sci Rep (2015)

Bottom Line: Fluoride infiltrated extensively in enamel to produce highly fluorinated fluorohydroxyapatite.In comparison, low-fluoride-level fluorinated fluorohydroxyapatite was formed on the enamel specimen exposed to toothpaste.It exhibited the potential as an effective fluoride delivery device for general use in prevention of caries.

View Article: PubMed Central - PubMed

Affiliation: Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University and National Taiwan University Hospital, No.1, Changde St., Jhongjheng District, Taipei 100, Taiwan.

ABSTRACT
There is no topically applicable low concentration fluoride delivery device available for caries prevention. This study was aimed to assess the use of a low concentration (1450 ppm) fluoride strip as an effective fluoride delivery system against enamel demineralization. The enamel surface composition and calcium-deficient hydroxyapatite or toothpaste treatments were investigated using X-ray photoelectron spectroscopy. In vitro enamel demineralization was assayed using a pH cycling model and the dissolution of calcium ions from the treated specimens was quantified using ion chromatography. After 24-hr fluoride-strip treatment, the enamel was covered with a CaF2 layer which showed a granular morphology of 1 μm in size. Below the CaF2 layer was a region of mixed fluorapatite and CaF2. Fluoride infiltrated extensively in enamel to produce highly fluorinated fluorohydroxyapatite. In comparison, low-fluoride-level fluorinated fluorohydroxyapatite was formed on the enamel specimen exposed to toothpaste. The treatments with the fluoride strip as short as 1 hr significantly inhibited enamel demineralization. The fluoride strip was effective for topical fluoride delivery and inhibited in vitro demineralization of enamel by forming CaF2 and fluoride-containing apatites at the enamel surface. It exhibited the potential as an effective fluoride delivery device for general use in prevention of caries.

No MeSH data available.


Related in: MedlinePlus

The chemical depth profile of enamel treated with a fluoride strip or toothpaste for 24 h.The dashed line represents predictions based on the data obtained.
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f6: The chemical depth profile of enamel treated with a fluoride strip or toothpaste for 24 h.The dashed line represents predictions based on the data obtained.

Mentions: FHAP’s fluoride content in the specimen exposed to toothpaste was less than that in the specimen exposed to the fluoride strip (Fig. 2(B,D)). The F/Ca ratio measured at 0 min etching time (Fig. 4(A,B)) indicated that, in comparison with the formation of FHAP in the toothpaste-treated specimen, extensive fluorinated FHAP (termed EFHAP) and FAP may be formed on the specimen exposed to the fluoride strip. The chemical depth profile in enamel treated with fluoride strip or toothpaste for 24 h is illustrated in Fig. 6.


Prevention of enamel demineralization with a novel fluoride strip: enamel surface composition and depth profile.

Lee BS, Chou PH, Chen SY, Liao HY, Chang CC - Sci Rep (2015)

The chemical depth profile of enamel treated with a fluoride strip or toothpaste for 24 h.The dashed line represents predictions based on the data obtained.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4543969&req=5

f6: The chemical depth profile of enamel treated with a fluoride strip or toothpaste for 24 h.The dashed line represents predictions based on the data obtained.
Mentions: FHAP’s fluoride content in the specimen exposed to toothpaste was less than that in the specimen exposed to the fluoride strip (Fig. 2(B,D)). The F/Ca ratio measured at 0 min etching time (Fig. 4(A,B)) indicated that, in comparison with the formation of FHAP in the toothpaste-treated specimen, extensive fluorinated FHAP (termed EFHAP) and FAP may be formed on the specimen exposed to the fluoride strip. The chemical depth profile in enamel treated with fluoride strip or toothpaste for 24 h is illustrated in Fig. 6.

Bottom Line: Fluoride infiltrated extensively in enamel to produce highly fluorinated fluorohydroxyapatite.In comparison, low-fluoride-level fluorinated fluorohydroxyapatite was formed on the enamel specimen exposed to toothpaste.It exhibited the potential as an effective fluoride delivery device for general use in prevention of caries.

View Article: PubMed Central - PubMed

Affiliation: Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University and National Taiwan University Hospital, No.1, Changde St., Jhongjheng District, Taipei 100, Taiwan.

ABSTRACT
There is no topically applicable low concentration fluoride delivery device available for caries prevention. This study was aimed to assess the use of a low concentration (1450 ppm) fluoride strip as an effective fluoride delivery system against enamel demineralization. The enamel surface composition and calcium-deficient hydroxyapatite or toothpaste treatments were investigated using X-ray photoelectron spectroscopy. In vitro enamel demineralization was assayed using a pH cycling model and the dissolution of calcium ions from the treated specimens was quantified using ion chromatography. After 24-hr fluoride-strip treatment, the enamel was covered with a CaF2 layer which showed a granular morphology of 1 μm in size. Below the CaF2 layer was a region of mixed fluorapatite and CaF2. Fluoride infiltrated extensively in enamel to produce highly fluorinated fluorohydroxyapatite. In comparison, low-fluoride-level fluorinated fluorohydroxyapatite was formed on the enamel specimen exposed to toothpaste. The treatments with the fluoride strip as short as 1 hr significantly inhibited enamel demineralization. The fluoride strip was effective for topical fluoride delivery and inhibited in vitro demineralization of enamel by forming CaF2 and fluoride-containing apatites at the enamel surface. It exhibited the potential as an effective fluoride delivery device for general use in prevention of caries.

No MeSH data available.


Related in: MedlinePlus