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Prevention of enamel demineralization with a novel fluoride strip: enamel surface composition and depth profile.

Lee BS, Chou PH, Chen SY, Liao HY, Chang CC - Sci Rep (2015)

Bottom Line: Fluoride infiltrated extensively in enamel to produce highly fluorinated fluorohydroxyapatite.In comparison, low-fluoride-level fluorinated fluorohydroxyapatite was formed on the enamel specimen exposed to toothpaste.It exhibited the potential as an effective fluoride delivery device for general use in prevention of caries.

View Article: PubMed Central - PubMed

Affiliation: Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University and National Taiwan University Hospital, No.1, Changde St., Jhongjheng District, Taipei 100, Taiwan.

ABSTRACT
There is no topically applicable low concentration fluoride delivery device available for caries prevention. This study was aimed to assess the use of a low concentration (1450 ppm) fluoride strip as an effective fluoride delivery system against enamel demineralization. The enamel surface composition and calcium-deficient hydroxyapatite or toothpaste treatments were investigated using X-ray photoelectron spectroscopy. In vitro enamel demineralization was assayed using a pH cycling model and the dissolution of calcium ions from the treated specimens was quantified using ion chromatography. After 24-hr fluoride-strip treatment, the enamel was covered with a CaF2 layer which showed a granular morphology of 1 μm in size. Below the CaF2 layer was a region of mixed fluorapatite and CaF2. Fluoride infiltrated extensively in enamel to produce highly fluorinated fluorohydroxyapatite. In comparison, low-fluoride-level fluorinated fluorohydroxyapatite was formed on the enamel specimen exposed to toothpaste. The treatments with the fluoride strip as short as 1 hr significantly inhibited enamel demineralization. The fluoride strip was effective for topical fluoride delivery and inhibited in vitro demineralization of enamel by forming CaF2 and fluoride-containing apatites at the enamel surface. It exhibited the potential as an effective fluoride delivery device for general use in prevention of caries.

No MeSH data available.


Related in: MedlinePlus

SEM images obtained from the enamel specimens (A) before and (B) after pH cycling. Dense granular structures were observed after fluoride-strip treatment for 24 h (C) and the granular structures diminished to some extent after KOH treatment (D). No particular morphology (like granular structures) was found after toothpaste treatment for 24 h (E) and the morphology remained after KOH treatment (F). The white scale bar at the lower right-hand corner of each image represents 10 μm.
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f5: SEM images obtained from the enamel specimens (A) before and (B) after pH cycling. Dense granular structures were observed after fluoride-strip treatment for 24 h (C) and the granular structures diminished to some extent after KOH treatment (D). No particular morphology (like granular structures) was found after toothpaste treatment for 24 h (E) and the morphology remained after KOH treatment (F). The white scale bar at the lower right-hand corner of each image represents 10 μm.

Mentions: SEM showed that, prior to treatments, human enamel had a smooth surface without any prominent features (Fig. 5(A)). After pH cycling, the surface became slightly rough (Fig. 5(B)). Granular structures were found on the surface after the fluoride-strip treatment for 24 h (Fig. 5(C)). They were reduced to some extent after KOH treatment (Fig. 5(D)). In contrast, the enamel surface did not exhibit particular morphology like granular structures after toothpaste treatment for 24 h (Fig. 5(E)). The morphology did not change prominently after KOH treatment (Fig. 5(F)).


Prevention of enamel demineralization with a novel fluoride strip: enamel surface composition and depth profile.

Lee BS, Chou PH, Chen SY, Liao HY, Chang CC - Sci Rep (2015)

SEM images obtained from the enamel specimens (A) before and (B) after pH cycling. Dense granular structures were observed after fluoride-strip treatment for 24 h (C) and the granular structures diminished to some extent after KOH treatment (D). No particular morphology (like granular structures) was found after toothpaste treatment for 24 h (E) and the morphology remained after KOH treatment (F). The white scale bar at the lower right-hand corner of each image represents 10 μm.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4543969&req=5

f5: SEM images obtained from the enamel specimens (A) before and (B) after pH cycling. Dense granular structures were observed after fluoride-strip treatment for 24 h (C) and the granular structures diminished to some extent after KOH treatment (D). No particular morphology (like granular structures) was found after toothpaste treatment for 24 h (E) and the morphology remained after KOH treatment (F). The white scale bar at the lower right-hand corner of each image represents 10 μm.
Mentions: SEM showed that, prior to treatments, human enamel had a smooth surface without any prominent features (Fig. 5(A)). After pH cycling, the surface became slightly rough (Fig. 5(B)). Granular structures were found on the surface after the fluoride-strip treatment for 24 h (Fig. 5(C)). They were reduced to some extent after KOH treatment (Fig. 5(D)). In contrast, the enamel surface did not exhibit particular morphology like granular structures after toothpaste treatment for 24 h (Fig. 5(E)). The morphology did not change prominently after KOH treatment (Fig. 5(F)).

Bottom Line: Fluoride infiltrated extensively in enamel to produce highly fluorinated fluorohydroxyapatite.In comparison, low-fluoride-level fluorinated fluorohydroxyapatite was formed on the enamel specimen exposed to toothpaste.It exhibited the potential as an effective fluoride delivery device for general use in prevention of caries.

View Article: PubMed Central - PubMed

Affiliation: Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University and National Taiwan University Hospital, No.1, Changde St., Jhongjheng District, Taipei 100, Taiwan.

ABSTRACT
There is no topically applicable low concentration fluoride delivery device available for caries prevention. This study was aimed to assess the use of a low concentration (1450 ppm) fluoride strip as an effective fluoride delivery system against enamel demineralization. The enamel surface composition and calcium-deficient hydroxyapatite or toothpaste treatments were investigated using X-ray photoelectron spectroscopy. In vitro enamel demineralization was assayed using a pH cycling model and the dissolution of calcium ions from the treated specimens was quantified using ion chromatography. After 24-hr fluoride-strip treatment, the enamel was covered with a CaF2 layer which showed a granular morphology of 1 μm in size. Below the CaF2 layer was a region of mixed fluorapatite and CaF2. Fluoride infiltrated extensively in enamel to produce highly fluorinated fluorohydroxyapatite. In comparison, low-fluoride-level fluorinated fluorohydroxyapatite was formed on the enamel specimen exposed to toothpaste. The treatments with the fluoride strip as short as 1 hr significantly inhibited enamel demineralization. The fluoride strip was effective for topical fluoride delivery and inhibited in vitro demineralization of enamel by forming CaF2 and fluoride-containing apatites at the enamel surface. It exhibited the potential as an effective fluoride delivery device for general use in prevention of caries.

No MeSH data available.


Related in: MedlinePlus