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Prevention of enamel demineralization with a novel fluoride strip: enamel surface composition and depth profile.

Lee BS, Chou PH, Chen SY, Liao HY, Chang CC - Sci Rep (2015)

Bottom Line: Fluoride infiltrated extensively in enamel to produce highly fluorinated fluorohydroxyapatite.In comparison, low-fluoride-level fluorinated fluorohydroxyapatite was formed on the enamel specimen exposed to toothpaste.It exhibited the potential as an effective fluoride delivery device for general use in prevention of caries.

View Article: PubMed Central - PubMed

Affiliation: Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University and National Taiwan University Hospital, No.1, Changde St., Jhongjheng District, Taipei 100, Taiwan.

ABSTRACT
There is no topically applicable low concentration fluoride delivery device available for caries prevention. This study was aimed to assess the use of a low concentration (1450 ppm) fluoride strip as an effective fluoride delivery system against enamel demineralization. The enamel surface composition and calcium-deficient hydroxyapatite or toothpaste treatments were investigated using X-ray photoelectron spectroscopy. In vitro enamel demineralization was assayed using a pH cycling model and the dissolution of calcium ions from the treated specimens was quantified using ion chromatography. After 24-hr fluoride-strip treatment, the enamel was covered with a CaF2 layer which showed a granular morphology of 1 μm in size. Below the CaF2 layer was a region of mixed fluorapatite and CaF2. Fluoride infiltrated extensively in enamel to produce highly fluorinated fluorohydroxyapatite. In comparison, low-fluoride-level fluorinated fluorohydroxyapatite was formed on the enamel specimen exposed to toothpaste. The treatments with the fluoride strip as short as 1 hr significantly inhibited enamel demineralization. The fluoride strip was effective for topical fluoride delivery and inhibited in vitro demineralization of enamel by forming CaF2 and fluoride-containing apatites at the enamel surface. It exhibited the potential as an effective fluoride delivery device for general use in prevention of caries.

No MeSH data available.


Related in: MedlinePlus

XPS depth profile of P 2p, O 1s, and F 1s for 24-hrs:(A) fluoride-strip- and (B) toothpaste-treated specimens, atomic ratio (to Ca) vs. sputtering time
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f4: XPS depth profile of P 2p, O 1s, and F 1s for 24-hrs:(A) fluoride-strip- and (B) toothpaste-treated specimens, atomic ratio (to Ca) vs. sputtering time

Mentions: Changes in atomic ratios for O/Ca, F/Ca, and P/Ca with ion etching time were observed in XPS depth profiling for the specimens receiving the fluoride-strip or toothpaste treatment (Fig. 4). After the fluoride-strip treatment for 24 h, the F/Ca ratio measured at 0 min of ion etching reached a high value of 1.75 (Fig. 4(A)). The ratio then gradually decreased to 0.30 after 75 min of ion etching and all three ratios became stable after 90 min of ion etching. After the toothpaste treatment for 24 h, the measured F/Ca ratio at 0 min of ion etching reached a value of 0.27 (Fig. 4(B)). It drastically decreased to ~0 within 5 min of ion etching and became almost unvaried with etching time thereafter. The initial O/Ca ratio was as high as 3.53. The O/Ca ratio dropped to 2.3 within 30 min of ion etching. It further decreased to the level of ~2.1 after 90 min of etching.


Prevention of enamel demineralization with a novel fluoride strip: enamel surface composition and depth profile.

Lee BS, Chou PH, Chen SY, Liao HY, Chang CC - Sci Rep (2015)

XPS depth profile of P 2p, O 1s, and F 1s for 24-hrs:(A) fluoride-strip- and (B) toothpaste-treated specimens, atomic ratio (to Ca) vs. sputtering time
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4543969&req=5

f4: XPS depth profile of P 2p, O 1s, and F 1s for 24-hrs:(A) fluoride-strip- and (B) toothpaste-treated specimens, atomic ratio (to Ca) vs. sputtering time
Mentions: Changes in atomic ratios for O/Ca, F/Ca, and P/Ca with ion etching time were observed in XPS depth profiling for the specimens receiving the fluoride-strip or toothpaste treatment (Fig. 4). After the fluoride-strip treatment for 24 h, the F/Ca ratio measured at 0 min of ion etching reached a high value of 1.75 (Fig. 4(A)). The ratio then gradually decreased to 0.30 after 75 min of ion etching and all three ratios became stable after 90 min of ion etching. After the toothpaste treatment for 24 h, the measured F/Ca ratio at 0 min of ion etching reached a value of 0.27 (Fig. 4(B)). It drastically decreased to ~0 within 5 min of ion etching and became almost unvaried with etching time thereafter. The initial O/Ca ratio was as high as 3.53. The O/Ca ratio dropped to 2.3 within 30 min of ion etching. It further decreased to the level of ~2.1 after 90 min of etching.

Bottom Line: Fluoride infiltrated extensively in enamel to produce highly fluorinated fluorohydroxyapatite.In comparison, low-fluoride-level fluorinated fluorohydroxyapatite was formed on the enamel specimen exposed to toothpaste.It exhibited the potential as an effective fluoride delivery device for general use in prevention of caries.

View Article: PubMed Central - PubMed

Affiliation: Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University and National Taiwan University Hospital, No.1, Changde St., Jhongjheng District, Taipei 100, Taiwan.

ABSTRACT
There is no topically applicable low concentration fluoride delivery device available for caries prevention. This study was aimed to assess the use of a low concentration (1450 ppm) fluoride strip as an effective fluoride delivery system against enamel demineralization. The enamel surface composition and calcium-deficient hydroxyapatite or toothpaste treatments were investigated using X-ray photoelectron spectroscopy. In vitro enamel demineralization was assayed using a pH cycling model and the dissolution of calcium ions from the treated specimens was quantified using ion chromatography. After 24-hr fluoride-strip treatment, the enamel was covered with a CaF2 layer which showed a granular morphology of 1 μm in size. Below the CaF2 layer was a region of mixed fluorapatite and CaF2. Fluoride infiltrated extensively in enamel to produce highly fluorinated fluorohydroxyapatite. In comparison, low-fluoride-level fluorinated fluorohydroxyapatite was formed on the enamel specimen exposed to toothpaste. The treatments with the fluoride strip as short as 1 hr significantly inhibited enamel demineralization. The fluoride strip was effective for topical fluoride delivery and inhibited in vitro demineralization of enamel by forming CaF2 and fluoride-containing apatites at the enamel surface. It exhibited the potential as an effective fluoride delivery device for general use in prevention of caries.

No MeSH data available.


Related in: MedlinePlus