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Prevention of enamel demineralization with a novel fluoride strip: enamel surface composition and depth profile.

Lee BS, Chou PH, Chen SY, Liao HY, Chang CC - Sci Rep (2015)

Bottom Line: Fluoride infiltrated extensively in enamel to produce highly fluorinated fluorohydroxyapatite.In comparison, low-fluoride-level fluorinated fluorohydroxyapatite was formed on the enamel specimen exposed to toothpaste.It exhibited the potential as an effective fluoride delivery device for general use in prevention of caries.

View Article: PubMed Central - PubMed

Affiliation: Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University and National Taiwan University Hospital, No.1, Changde St., Jhongjheng District, Taipei 100, Taiwan.

ABSTRACT
There is no topically applicable low concentration fluoride delivery device available for caries prevention. This study was aimed to assess the use of a low concentration (1450 ppm) fluoride strip as an effective fluoride delivery system against enamel demineralization. The enamel surface composition and calcium-deficient hydroxyapatite or toothpaste treatments were investigated using X-ray photoelectron spectroscopy. In vitro enamel demineralization was assayed using a pH cycling model and the dissolution of calcium ions from the treated specimens was quantified using ion chromatography. After 24-hr fluoride-strip treatment, the enamel was covered with a CaF2 layer which showed a granular morphology of 1 μm in size. Below the CaF2 layer was a region of mixed fluorapatite and CaF2. Fluoride infiltrated extensively in enamel to produce highly fluorinated fluorohydroxyapatite. In comparison, low-fluoride-level fluorinated fluorohydroxyapatite was formed on the enamel specimen exposed to toothpaste. The treatments with the fluoride strip as short as 1 hr significantly inhibited enamel demineralization. The fluoride strip was effective for topical fluoride delivery and inhibited in vitro demineralization of enamel by forming CaF2 and fluoride-containing apatites at the enamel surface. It exhibited the potential as an effective fluoride delivery device for general use in prevention of caries.

No MeSH data available.


Related in: MedlinePlus

(A,C) Ca 2p and (B,D) F 1s XPS spectra taken from the 24-hr, (A,B) fluoride-strip- and (C,D) toothpaste-treated specimen surfaces following ion etching for the specified periods of time. Their related Ca 2p and F 1s spectra taken from the pristine enamel are included in respective plots for comparison.
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f3: (A,C) Ca 2p and (B,D) F 1s XPS spectra taken from the 24-hr, (A,B) fluoride-strip- and (C,D) toothpaste-treated specimen surfaces following ion etching for the specified periods of time. Their related Ca 2p and F 1s spectra taken from the pristine enamel are included in respective plots for comparison.

Mentions: The XPS depth profiling of the enamel treated with the fluoride strip or toothpaste for 24 hrs is shown in Fig. 3. For the fluoride strip group, the Ca 2p peak shifted into the direction of lower binding energy, in addition to the peak broadening due to differential surface charging induced by the sputtering from ion etching, as the time under ion etching increased (Fig. 3(A)). It shifted almost back to the Ca 2p peak position of enamel after etching for 75 min. However, the F 1s peak was still detected after ion etching for 150 min (Fig. 3(B)). For the toothpaste group, the Ca 2p peak shifted with ion etching time into the direction of higher binding energy, as the time under ion etching increased (Fig. 3(C)). It also shifted almost back to the Ca 2p peak position of enamel after ion etching for 75 min. The F 1s signal was detected up to the ion etching time of 45 min only (Fig. 3(D)).


Prevention of enamel demineralization with a novel fluoride strip: enamel surface composition and depth profile.

Lee BS, Chou PH, Chen SY, Liao HY, Chang CC - Sci Rep (2015)

(A,C) Ca 2p and (B,D) F 1s XPS spectra taken from the 24-hr, (A,B) fluoride-strip- and (C,D) toothpaste-treated specimen surfaces following ion etching for the specified periods of time. Their related Ca 2p and F 1s spectra taken from the pristine enamel are included in respective plots for comparison.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4543969&req=5

f3: (A,C) Ca 2p and (B,D) F 1s XPS spectra taken from the 24-hr, (A,B) fluoride-strip- and (C,D) toothpaste-treated specimen surfaces following ion etching for the specified periods of time. Their related Ca 2p and F 1s spectra taken from the pristine enamel are included in respective plots for comparison.
Mentions: The XPS depth profiling of the enamel treated with the fluoride strip or toothpaste for 24 hrs is shown in Fig. 3. For the fluoride strip group, the Ca 2p peak shifted into the direction of lower binding energy, in addition to the peak broadening due to differential surface charging induced by the sputtering from ion etching, as the time under ion etching increased (Fig. 3(A)). It shifted almost back to the Ca 2p peak position of enamel after etching for 75 min. However, the F 1s peak was still detected after ion etching for 150 min (Fig. 3(B)). For the toothpaste group, the Ca 2p peak shifted with ion etching time into the direction of higher binding energy, as the time under ion etching increased (Fig. 3(C)). It also shifted almost back to the Ca 2p peak position of enamel after ion etching for 75 min. The F 1s signal was detected up to the ion etching time of 45 min only (Fig. 3(D)).

Bottom Line: Fluoride infiltrated extensively in enamel to produce highly fluorinated fluorohydroxyapatite.In comparison, low-fluoride-level fluorinated fluorohydroxyapatite was formed on the enamel specimen exposed to toothpaste.It exhibited the potential as an effective fluoride delivery device for general use in prevention of caries.

View Article: PubMed Central - PubMed

Affiliation: Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University and National Taiwan University Hospital, No.1, Changde St., Jhongjheng District, Taipei 100, Taiwan.

ABSTRACT
There is no topically applicable low concentration fluoride delivery device available for caries prevention. This study was aimed to assess the use of a low concentration (1450 ppm) fluoride strip as an effective fluoride delivery system against enamel demineralization. The enamel surface composition and calcium-deficient hydroxyapatite or toothpaste treatments were investigated using X-ray photoelectron spectroscopy. In vitro enamel demineralization was assayed using a pH cycling model and the dissolution of calcium ions from the treated specimens was quantified using ion chromatography. After 24-hr fluoride-strip treatment, the enamel was covered with a CaF2 layer which showed a granular morphology of 1 μm in size. Below the CaF2 layer was a region of mixed fluorapatite and CaF2. Fluoride infiltrated extensively in enamel to produce highly fluorinated fluorohydroxyapatite. In comparison, low-fluoride-level fluorinated fluorohydroxyapatite was formed on the enamel specimen exposed to toothpaste. The treatments with the fluoride strip as short as 1 hr significantly inhibited enamel demineralization. The fluoride strip was effective for topical fluoride delivery and inhibited in vitro demineralization of enamel by forming CaF2 and fluoride-containing apatites at the enamel surface. It exhibited the potential as an effective fluoride delivery device for general use in prevention of caries.

No MeSH data available.


Related in: MedlinePlus