Limits...
Carbonic Anhydrase XII as an Independent Prognostic Factor in Advanced Esophageal Squamous Cell Carcinoma.

Ochi F, Shiozaki A, Ichikawa D, Fujiwara H, Nakashima S, Takemoto K, Kosuga T, Konishi H, Komatsu S, Okamoto K, Kishimoto M, Marunaka Y, Otsuji E - J Cancer (2015)

Bottom Line: Although the expression of CA XII was related to the pT category, it had no prognostic impact.We then examined the expression of CA XII according to the pT category.In pT2-3 ESCC, the 3-year survival rate of patients with the high grade expression of CA XII (29.1 %) was significantly lower than that of patients with the low grade expression of CA XII (70.3 %).

View Article: PubMed Central - PubMed

Affiliation: 1. Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, 602-8566, Japan.

ABSTRACT

Background: Although recent studies described important roles for carbonic anhydrase (CA) XII in epithelial carcinogenesis and tumor behavior, a consensus has not yet been reached regarding its clinicopathological significance in esophageal squamous cell carcinoma (ESCC). In the present study, we investigated its prognostic significance in ESCC.

Materials and methods: An immunohistochemical analysis was performed on 70 primary tumor samples obtained from ESCC patients who underwent esophagectomy, and the relationships between the expression of CA XII and various clinicopathological features or prognosis were analyzed.

Results: Immunohistochemical staining showed that CA XII was primarily found in the cell membranes of carcinoma cells. Although the expression of CA XII was related to the pT category, it had no prognostic impact. We then examined the expression of CA XII according to the pT category. In pT2-3 ESCC, the 3-year survival rate of patients with the high grade expression of CA XII (29.1 %) was significantly lower than that of patients with the low grade expression of CA XII (70.3 %). Furthermore, a multivariate analysis demonstrated that the expression of CA XII was one of the most important independent prognostic factors following radical esophagectomy in pT2-3 ESCC.

Conclusion: These results suggest that the expression of CA XII may be a valuable prognostic factor for patients with advanced ESCC. The results of the present study provide an insight into the role of CA XII as a biomarker in ESCC.

No MeSH data available.


Related in: MedlinePlus

Survival curve of patients after curative resection for esophageal squamous cell carcinoma (ESCC) according to the expression of CA XII. A: All patients were classified into two groups: the low grade expression of CA XII (n=35) and high grade expression of CA XII (n=35). B: Patients with pT1 ESCC were classified into two groups: the low grade expression of CA XII (n=11) and high grade expression of CA XII (n=22). C: Patients with pT2-3 ESCC were classified into two groups: the low grade expression of CA XII (n=24) and high grade expression of CA XII (n=13). *p<0.05: log-rank test.
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC4543752&req=5

Figure 3: Survival curve of patients after curative resection for esophageal squamous cell carcinoma (ESCC) according to the expression of CA XII. A: All patients were classified into two groups: the low grade expression of CA XII (n=35) and high grade expression of CA XII (n=35). B: Patients with pT1 ESCC were classified into two groups: the low grade expression of CA XII (n=11) and high grade expression of CA XII (n=22). C: Patients with pT2-3 ESCC were classified into two groups: the low grade expression of CA XII (n=24) and high grade expression of CA XII (n=13). *p<0.05: log-rank test.

Mentions: We determined the prognostic impact of the expression of CA XII for patients with ESCC. No significant difference was observed in the overall 3-year survival rate between patients with the high grade expression of CA XII and those with the low grade expression of CA XII (Fig. 3A). Similarly, no significant differences were observed in the 3-year survival rate between patients with CA XII expression in the invasive front (70.8%) and that of the patients without it (71.5%) (p=0.764). We then analyzed the prognostic significance of the expression of CA XII according to the pT category. In patients with pT1 ESCC, no significant difference was observed in the 3-year survival rate between patients with the high grade expression of CA XII and those with the low grade expression of CA XII (Fig. 3B). On the other hand, in patients with pT2-3 ESCC, the 3-year survival rate of patients with the high grade expression of CA XII (29.1 %) was significantly lower than that of patients with the low grade expression of CA XII (70.3 %) (p = 0.011) (Fig. 3C).


Carbonic Anhydrase XII as an Independent Prognostic Factor in Advanced Esophageal Squamous Cell Carcinoma.

Ochi F, Shiozaki A, Ichikawa D, Fujiwara H, Nakashima S, Takemoto K, Kosuga T, Konishi H, Komatsu S, Okamoto K, Kishimoto M, Marunaka Y, Otsuji E - J Cancer (2015)

Survival curve of patients after curative resection for esophageal squamous cell carcinoma (ESCC) according to the expression of CA XII. A: All patients were classified into two groups: the low grade expression of CA XII (n=35) and high grade expression of CA XII (n=35). B: Patients with pT1 ESCC were classified into two groups: the low grade expression of CA XII (n=11) and high grade expression of CA XII (n=22). C: Patients with pT2-3 ESCC were classified into two groups: the low grade expression of CA XII (n=24) and high grade expression of CA XII (n=13). *p<0.05: log-rank test.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4543752&req=5

Figure 3: Survival curve of patients after curative resection for esophageal squamous cell carcinoma (ESCC) according to the expression of CA XII. A: All patients were classified into two groups: the low grade expression of CA XII (n=35) and high grade expression of CA XII (n=35). B: Patients with pT1 ESCC were classified into two groups: the low grade expression of CA XII (n=11) and high grade expression of CA XII (n=22). C: Patients with pT2-3 ESCC were classified into two groups: the low grade expression of CA XII (n=24) and high grade expression of CA XII (n=13). *p<0.05: log-rank test.
Mentions: We determined the prognostic impact of the expression of CA XII for patients with ESCC. No significant difference was observed in the overall 3-year survival rate between patients with the high grade expression of CA XII and those with the low grade expression of CA XII (Fig. 3A). Similarly, no significant differences were observed in the 3-year survival rate between patients with CA XII expression in the invasive front (70.8%) and that of the patients without it (71.5%) (p=0.764). We then analyzed the prognostic significance of the expression of CA XII according to the pT category. In patients with pT1 ESCC, no significant difference was observed in the 3-year survival rate between patients with the high grade expression of CA XII and those with the low grade expression of CA XII (Fig. 3B). On the other hand, in patients with pT2-3 ESCC, the 3-year survival rate of patients with the high grade expression of CA XII (29.1 %) was significantly lower than that of patients with the low grade expression of CA XII (70.3 %) (p = 0.011) (Fig. 3C).

Bottom Line: Although the expression of CA XII was related to the pT category, it had no prognostic impact.We then examined the expression of CA XII according to the pT category.In pT2-3 ESCC, the 3-year survival rate of patients with the high grade expression of CA XII (29.1 %) was significantly lower than that of patients with the low grade expression of CA XII (70.3 %).

View Article: PubMed Central - PubMed

Affiliation: 1. Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, 602-8566, Japan.

ABSTRACT

Background: Although recent studies described important roles for carbonic anhydrase (CA) XII in epithelial carcinogenesis and tumor behavior, a consensus has not yet been reached regarding its clinicopathological significance in esophageal squamous cell carcinoma (ESCC). In the present study, we investigated its prognostic significance in ESCC.

Materials and methods: An immunohistochemical analysis was performed on 70 primary tumor samples obtained from ESCC patients who underwent esophagectomy, and the relationships between the expression of CA XII and various clinicopathological features or prognosis were analyzed.

Results: Immunohistochemical staining showed that CA XII was primarily found in the cell membranes of carcinoma cells. Although the expression of CA XII was related to the pT category, it had no prognostic impact. We then examined the expression of CA XII according to the pT category. In pT2-3 ESCC, the 3-year survival rate of patients with the high grade expression of CA XII (29.1 %) was significantly lower than that of patients with the low grade expression of CA XII (70.3 %). Furthermore, a multivariate analysis demonstrated that the expression of CA XII was one of the most important independent prognostic factors following radical esophagectomy in pT2-3 ESCC.

Conclusion: These results suggest that the expression of CA XII may be a valuable prognostic factor for patients with advanced ESCC. The results of the present study provide an insight into the role of CA XII as a biomarker in ESCC.

No MeSH data available.


Related in: MedlinePlus