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Gene expression changes in subcutaneous adipose tissue due to Cushing's disease.

Hochberg I, Harvey I, Tran QT, Stephenson EJ, Barkan AL, Saltiel AR, Chandler WF, Bridges D - J. Mol. Endocrinol. (2015)

Bottom Line: Glucocorticoids have major effects on adipose tissue metabolism.We found a higher expression of transcripts involved in several metabolic pathways, including lipogenesis, proteolysis and glucose oxidation as well as a decreased expression of transcripts involved in inflammation and protein synthesis.These data provide insight to transcriptional changes that may be responsible for the comorbidities associated with chronic elevations of glucocorticoids.

View Article: PubMed Central - PubMed

Affiliation: Institute of EndocrinologyDiabetes and Metabolism, Rambam Health Care Campus, Haifa, IsraelLife Science InstituteUniversity of Michigan, Ann Arbor, MI, USAPhysiologyUTHSC, Memphis, TN, USAPreventive MedicineUTHSC, Memphis, TN, USAInternal MedicineUniversity of Michigan, Ann Arbor, MI USANeurosurgeryUniversity of Michigan, Ann Arbor, MI USAPediatricsUTHSC, Memphis, TN, USA Institute of EndocrinologyDiabetes and Metabolism, Rambam Health Care Campus, Haifa, IsraelLife Science InstituteUniversity of Michigan, Ann Arbor, MI, USAPhysiologyUTHSC, Memphis, TN, USAPreventive MedicineUTHSC, Memphis, TN, USAInternal MedicineUniversity of Michigan, Ann Arbor, MI USANeurosurgeryUniversity of Michigan, Ann Arbor, MI USAPediatricsUTHSC, Memphis, TN, USA i_hochberg@rambam.health.gov.il dbridge9@uthsc.edu.

No MeSH data available.


Related in: MedlinePlus

Differentially expressed transcripts in subcutaneous adipose tissue from Cushing's disease subjects. (A) Heatmap of genes with significant differential expression. The bar on the top indicates control subjects (non-secreting adenoma; black) and Cushing's subjects (red). (B) Genes involved in cortisol signaling. (C) Leptin and adiponectin mRNA levels. *q<0.05.
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fig3: Differentially expressed transcripts in subcutaneous adipose tissue from Cushing's disease subjects. (A) Heatmap of genes with significant differential expression. The bar on the top indicates control subjects (non-secreting adenoma; black) and Cushing's subjects (red). (B) Genes involved in cortisol signaling. (C) Leptin and adiponectin mRNA levels. *q<0.05.

Mentions: To determine which genes and pathways are altered in the adipose tissue in the human Cushing's disease subjects, we analyzed the transcriptome from subcutaneous adipose tissue mRNA from the five Cushing's disease patients and 11 controls. We identified 473 genes that had significantly different expressions in Cushing's disease patients; of these, 192 genes were expressed at a lower level and 281 at a higher level in the adipose tissue from the disease patients. These transcripts form a signature identifying transcriptional difference in the adipose tissue in response to long-term exposure to glucocorticoids (Fig. 3A).


Gene expression changes in subcutaneous adipose tissue due to Cushing's disease.

Hochberg I, Harvey I, Tran QT, Stephenson EJ, Barkan AL, Saltiel AR, Chandler WF, Bridges D - J. Mol. Endocrinol. (2015)

Differentially expressed transcripts in subcutaneous adipose tissue from Cushing's disease subjects. (A) Heatmap of genes with significant differential expression. The bar on the top indicates control subjects (non-secreting adenoma; black) and Cushing's subjects (red). (B) Genes involved in cortisol signaling. (C) Leptin and adiponectin mRNA levels. *q<0.05.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4543687&req=5

fig3: Differentially expressed transcripts in subcutaneous adipose tissue from Cushing's disease subjects. (A) Heatmap of genes with significant differential expression. The bar on the top indicates control subjects (non-secreting adenoma; black) and Cushing's subjects (red). (B) Genes involved in cortisol signaling. (C) Leptin and adiponectin mRNA levels. *q<0.05.
Mentions: To determine which genes and pathways are altered in the adipose tissue in the human Cushing's disease subjects, we analyzed the transcriptome from subcutaneous adipose tissue mRNA from the five Cushing's disease patients and 11 controls. We identified 473 genes that had significantly different expressions in Cushing's disease patients; of these, 192 genes were expressed at a lower level and 281 at a higher level in the adipose tissue from the disease patients. These transcripts form a signature identifying transcriptional difference in the adipose tissue in response to long-term exposure to glucocorticoids (Fig. 3A).

Bottom Line: Glucocorticoids have major effects on adipose tissue metabolism.We found a higher expression of transcripts involved in several metabolic pathways, including lipogenesis, proteolysis and glucose oxidation as well as a decreased expression of transcripts involved in inflammation and protein synthesis.These data provide insight to transcriptional changes that may be responsible for the comorbidities associated with chronic elevations of glucocorticoids.

View Article: PubMed Central - PubMed

Affiliation: Institute of EndocrinologyDiabetes and Metabolism, Rambam Health Care Campus, Haifa, IsraelLife Science InstituteUniversity of Michigan, Ann Arbor, MI, USAPhysiologyUTHSC, Memphis, TN, USAPreventive MedicineUTHSC, Memphis, TN, USAInternal MedicineUniversity of Michigan, Ann Arbor, MI USANeurosurgeryUniversity of Michigan, Ann Arbor, MI USAPediatricsUTHSC, Memphis, TN, USA Institute of EndocrinologyDiabetes and Metabolism, Rambam Health Care Campus, Haifa, IsraelLife Science InstituteUniversity of Michigan, Ann Arbor, MI, USAPhysiologyUTHSC, Memphis, TN, USAPreventive MedicineUTHSC, Memphis, TN, USAInternal MedicineUniversity of Michigan, Ann Arbor, MI USANeurosurgeryUniversity of Michigan, Ann Arbor, MI USAPediatricsUTHSC, Memphis, TN, USA i_hochberg@rambam.health.gov.il dbridge9@uthsc.edu.

No MeSH data available.


Related in: MedlinePlus