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Gene expression changes in subcutaneous adipose tissue due to Cushing's disease.

Hochberg I, Harvey I, Tran QT, Stephenson EJ, Barkan AL, Saltiel AR, Chandler WF, Bridges D - J. Mol. Endocrinol. (2015)

Bottom Line: Glucocorticoids have major effects on adipose tissue metabolism.We found a higher expression of transcripts involved in several metabolic pathways, including lipogenesis, proteolysis and glucose oxidation as well as a decreased expression of transcripts involved in inflammation and protein synthesis.These data provide insight to transcriptional changes that may be responsible for the comorbidities associated with chronic elevations of glucocorticoids.

View Article: PubMed Central - PubMed

Affiliation: Institute of EndocrinologyDiabetes and Metabolism, Rambam Health Care Campus, Haifa, IsraelLife Science InstituteUniversity of Michigan, Ann Arbor, MI, USAPhysiologyUTHSC, Memphis, TN, USAPreventive MedicineUTHSC, Memphis, TN, USAInternal MedicineUniversity of Michigan, Ann Arbor, MI USANeurosurgeryUniversity of Michigan, Ann Arbor, MI USAPediatricsUTHSC, Memphis, TN, USA Institute of EndocrinologyDiabetes and Metabolism, Rambam Health Care Campus, Haifa, IsraelLife Science InstituteUniversity of Michigan, Ann Arbor, MI, USAPhysiologyUTHSC, Memphis, TN, USAPreventive MedicineUTHSC, Memphis, TN, USAInternal MedicineUniversity of Michigan, Ann Arbor, MI USANeurosurgeryUniversity of Michigan, Ann Arbor, MI USAPediatricsUTHSC, Memphis, TN, USA i_hochberg@rambam.health.gov.il dbridge9@uthsc.edu.

No MeSH data available.


Related in: MedlinePlus

Metabolic characteristics of Cushing's disease patients in our study. (A) Morphometric data from control (non-secreting adeoma) and Cushing's disease subjects. A.C., abdominal circumference. (B) HOMA-IR score, fasting insulin and fasting blood glucose from subjects. (C) Liver enzymes from subjects (D) Glycerol release from isolated subcutaneous adipose tissue. *P<0.05.
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fig1: Metabolic characteristics of Cushing's disease patients in our study. (A) Morphometric data from control (non-secreting adeoma) and Cushing's disease subjects. A.C., abdominal circumference. (B) HOMA-IR score, fasting insulin and fasting blood glucose from subjects. (C) Liver enzymes from subjects (D) Glycerol release from isolated subcutaneous adipose tissue. *P<0.05.

Mentions: Clinical and metabolic measurements were obtained for five Cushing's disease patients and 11 control subjects, who were admitted with non-secreting adenomas. Patient characteristics are shown in Table 2. Our Cushing's disease patients were, in general, younger and had smaller tumors than the patients with non-secreting adenomas. In the Cushing's disease cohort there was a nonsignificant elevation in body weight (P=0.47), BMI (P=0.27) and abdominal circumference (P=0.07, Fig. 1A), consistent with Cushing's disease patients with elevated fat mass and truncal obesity (Lamberts & Birkenhäger 1976).


Gene expression changes in subcutaneous adipose tissue due to Cushing's disease.

Hochberg I, Harvey I, Tran QT, Stephenson EJ, Barkan AL, Saltiel AR, Chandler WF, Bridges D - J. Mol. Endocrinol. (2015)

Metabolic characteristics of Cushing's disease patients in our study. (A) Morphometric data from control (non-secreting adeoma) and Cushing's disease subjects. A.C., abdominal circumference. (B) HOMA-IR score, fasting insulin and fasting blood glucose from subjects. (C) Liver enzymes from subjects (D) Glycerol release from isolated subcutaneous adipose tissue. *P<0.05.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4543687&req=5

fig1: Metabolic characteristics of Cushing's disease patients in our study. (A) Morphometric data from control (non-secreting adeoma) and Cushing's disease subjects. A.C., abdominal circumference. (B) HOMA-IR score, fasting insulin and fasting blood glucose from subjects. (C) Liver enzymes from subjects (D) Glycerol release from isolated subcutaneous adipose tissue. *P<0.05.
Mentions: Clinical and metabolic measurements were obtained for five Cushing's disease patients and 11 control subjects, who were admitted with non-secreting adenomas. Patient characteristics are shown in Table 2. Our Cushing's disease patients were, in general, younger and had smaller tumors than the patients with non-secreting adenomas. In the Cushing's disease cohort there was a nonsignificant elevation in body weight (P=0.47), BMI (P=0.27) and abdominal circumference (P=0.07, Fig. 1A), consistent with Cushing's disease patients with elevated fat mass and truncal obesity (Lamberts & Birkenhäger 1976).

Bottom Line: Glucocorticoids have major effects on adipose tissue metabolism.We found a higher expression of transcripts involved in several metabolic pathways, including lipogenesis, proteolysis and glucose oxidation as well as a decreased expression of transcripts involved in inflammation and protein synthesis.These data provide insight to transcriptional changes that may be responsible for the comorbidities associated with chronic elevations of glucocorticoids.

View Article: PubMed Central - PubMed

Affiliation: Institute of EndocrinologyDiabetes and Metabolism, Rambam Health Care Campus, Haifa, IsraelLife Science InstituteUniversity of Michigan, Ann Arbor, MI, USAPhysiologyUTHSC, Memphis, TN, USAPreventive MedicineUTHSC, Memphis, TN, USAInternal MedicineUniversity of Michigan, Ann Arbor, MI USANeurosurgeryUniversity of Michigan, Ann Arbor, MI USAPediatricsUTHSC, Memphis, TN, USA Institute of EndocrinologyDiabetes and Metabolism, Rambam Health Care Campus, Haifa, IsraelLife Science InstituteUniversity of Michigan, Ann Arbor, MI, USAPhysiologyUTHSC, Memphis, TN, USAPreventive MedicineUTHSC, Memphis, TN, USAInternal MedicineUniversity of Michigan, Ann Arbor, MI USANeurosurgeryUniversity of Michigan, Ann Arbor, MI USAPediatricsUTHSC, Memphis, TN, USA i_hochberg@rambam.health.gov.il dbridge9@uthsc.edu.

No MeSH data available.


Related in: MedlinePlus