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Abnormal auditory and language pathways in children with 16p11.2 deletion.

Berman JI, Chudnovskaya D, Blaskey L, Kuschner E, Mukherjee P, Buckner R, Nagarajan S, Chung WK, Spiro JE, Sherr EH, Roberts TP - Neuroimage Clin (2015)

Bottom Line: In both tracts, deletion carriers exhibited significantly higher diffusivity than that of controls.Within deletion carriers, the left-hemisphere arcuate fasciculus mean and radial diffusivities were significantly negatively correlated with clinical language ability, but not non-verbal cognitive ability.Diffusion metrics in the right-hemisphere arcuate fasciculus were not predictive of language ability.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Children's Hospital of Philadelphia, 34th and Civic Center Blvd, Philadelphia, PA 19104, USA ; Department of Radiology, Perelman School of Medicine University of Pennsylvania, 34th and Civic Center Blvd, Philadelphia, PA 19104, USA.

ABSTRACT
Copy number variations at chromosome 16p11.2 contribute to neurodevelopmental disorders, including autism spectrum disorder (ASD). This study seeks to improve our understanding of the biological basis of behavioral phenotypes common in ASD, in particular the prominent and prevalent disruption of spoken language seen in children with the 16p11.2 BP4-BP5 deletion. We examined the auditory and language white matter pathways with diffusion MRI in a cohort of 36 pediatric deletion carriers and 45 age-matched controls. Diffusion MR tractography of the auditory radiations and the arcuate fasciculus was performed to generate tract specific measures of white matter microstructure. In both tracts, deletion carriers exhibited significantly higher diffusivity than that of controls. Cross-sectional diffusion parameters in these tracts changed with age with no group difference in the rate of maturation. Within deletion carriers, the left-hemisphere arcuate fasciculus mean and radial diffusivities were significantly negatively correlated with clinical language ability, but not non-verbal cognitive ability. Diffusion metrics in the right-hemisphere arcuate fasciculus were not predictive of language ability. These results provide insight into the link between the 16p11.2 deletion, abnormal auditory and language pathway structures, and the specific behavioral deficits that may contribute to neurodevelopmental disorders such as ASD.

No MeSH data available.


Related in: MedlinePlus

Correlation of diffusion metrics and language ability in the left hemisphere arcuate fasciculus. Deletion carriers with an ASD diagnosis are indicated with asterisk markers. Scatter plots include variance from covariates which are controlled for in the multivariate regression.
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f0020: Correlation of diffusion metrics and language ability in the left hemisphere arcuate fasciculus. Deletion carriers with an ASD diagnosis are indicated with asterisk markers. Scatter plots include variance from covariates which are controlled for in the multivariate regression.

Mentions: In the deletion group, left-hemisphere arcuate fasciculus mean diffusivity (p < 0.05, R2 = 0.55) and radial diffusivity (p = 0.02, R2 = 0.60) exhibited a significant negative relationship with CELF-4 core language index, but not non-verbal cognitive ability (Table 4). Left hemisphere arcuate fasciculus FA showed a trend level relationship with language in the deletion group (p = 0.07, R2 = 0.45). In controls, left-hemisphere arcuate fasciculus axial diffusivity was correlated with CELF-4 core language index and non-verbal IQ (p = 0.02 each, R2 = 0.28). Fig. 4 shows the relationship of DTI parameters with CELF-4 in both the deletion carrier and control groups. Auditory radiation mean diffusivity in the control group was predictive of language ability (p < 0.02, R2 = 0.31, Table 5).


Abnormal auditory and language pathways in children with 16p11.2 deletion.

Berman JI, Chudnovskaya D, Blaskey L, Kuschner E, Mukherjee P, Buckner R, Nagarajan S, Chung WK, Spiro JE, Sherr EH, Roberts TP - Neuroimage Clin (2015)

Correlation of diffusion metrics and language ability in the left hemisphere arcuate fasciculus. Deletion carriers with an ASD diagnosis are indicated with asterisk markers. Scatter plots include variance from covariates which are controlled for in the multivariate regression.
© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4543079&req=5

f0020: Correlation of diffusion metrics and language ability in the left hemisphere arcuate fasciculus. Deletion carriers with an ASD diagnosis are indicated with asterisk markers. Scatter plots include variance from covariates which are controlled for in the multivariate regression.
Mentions: In the deletion group, left-hemisphere arcuate fasciculus mean diffusivity (p < 0.05, R2 = 0.55) and radial diffusivity (p = 0.02, R2 = 0.60) exhibited a significant negative relationship with CELF-4 core language index, but not non-verbal cognitive ability (Table 4). Left hemisphere arcuate fasciculus FA showed a trend level relationship with language in the deletion group (p = 0.07, R2 = 0.45). In controls, left-hemisphere arcuate fasciculus axial diffusivity was correlated with CELF-4 core language index and non-verbal IQ (p = 0.02 each, R2 = 0.28). Fig. 4 shows the relationship of DTI parameters with CELF-4 in both the deletion carrier and control groups. Auditory radiation mean diffusivity in the control group was predictive of language ability (p < 0.02, R2 = 0.31, Table 5).

Bottom Line: In both tracts, deletion carriers exhibited significantly higher diffusivity than that of controls.Within deletion carriers, the left-hemisphere arcuate fasciculus mean and radial diffusivities were significantly negatively correlated with clinical language ability, but not non-verbal cognitive ability.Diffusion metrics in the right-hemisphere arcuate fasciculus were not predictive of language ability.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Children's Hospital of Philadelphia, 34th and Civic Center Blvd, Philadelphia, PA 19104, USA ; Department of Radiology, Perelman School of Medicine University of Pennsylvania, 34th and Civic Center Blvd, Philadelphia, PA 19104, USA.

ABSTRACT
Copy number variations at chromosome 16p11.2 contribute to neurodevelopmental disorders, including autism spectrum disorder (ASD). This study seeks to improve our understanding of the biological basis of behavioral phenotypes common in ASD, in particular the prominent and prevalent disruption of spoken language seen in children with the 16p11.2 BP4-BP5 deletion. We examined the auditory and language white matter pathways with diffusion MRI in a cohort of 36 pediatric deletion carriers and 45 age-matched controls. Diffusion MR tractography of the auditory radiations and the arcuate fasciculus was performed to generate tract specific measures of white matter microstructure. In both tracts, deletion carriers exhibited significantly higher diffusivity than that of controls. Cross-sectional diffusion parameters in these tracts changed with age with no group difference in the rate of maturation. Within deletion carriers, the left-hemisphere arcuate fasciculus mean and radial diffusivities were significantly negatively correlated with clinical language ability, but not non-verbal cognitive ability. Diffusion metrics in the right-hemisphere arcuate fasciculus were not predictive of language ability. These results provide insight into the link between the 16p11.2 deletion, abnormal auditory and language pathway structures, and the specific behavioral deficits that may contribute to neurodevelopmental disorders such as ASD.

No MeSH data available.


Related in: MedlinePlus