Limits...
Abnormal auditory and language pathways in children with 16p11.2 deletion.

Berman JI, Chudnovskaya D, Blaskey L, Kuschner E, Mukherjee P, Buckner R, Nagarajan S, Chung WK, Spiro JE, Sherr EH, Roberts TP - Neuroimage Clin (2015)

Bottom Line: In both tracts, deletion carriers exhibited significantly higher diffusivity than that of controls.Within deletion carriers, the left-hemisphere arcuate fasciculus mean and radial diffusivities were significantly negatively correlated with clinical language ability, but not non-verbal cognitive ability.Diffusion metrics in the right-hemisphere arcuate fasciculus were not predictive of language ability.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Children's Hospital of Philadelphia, 34th and Civic Center Blvd, Philadelphia, PA 19104, USA ; Department of Radiology, Perelman School of Medicine University of Pennsylvania, 34th and Civic Center Blvd, Philadelphia, PA 19104, USA.

ABSTRACT
Copy number variations at chromosome 16p11.2 contribute to neurodevelopmental disorders, including autism spectrum disorder (ASD). This study seeks to improve our understanding of the biological basis of behavioral phenotypes common in ASD, in particular the prominent and prevalent disruption of spoken language seen in children with the 16p11.2 BP4-BP5 deletion. We examined the auditory and language white matter pathways with diffusion MRI in a cohort of 36 pediatric deletion carriers and 45 age-matched controls. Diffusion MR tractography of the auditory radiations and the arcuate fasciculus was performed to generate tract specific measures of white matter microstructure. In both tracts, deletion carriers exhibited significantly higher diffusivity than that of controls. Cross-sectional diffusion parameters in these tracts changed with age with no group difference in the rate of maturation. Within deletion carriers, the left-hemisphere arcuate fasciculus mean and radial diffusivities were significantly negatively correlated with clinical language ability, but not non-verbal cognitive ability. Diffusion metrics in the right-hemisphere arcuate fasciculus were not predictive of language ability. These results provide insight into the link between the 16p11.2 deletion, abnormal auditory and language pathway structures, and the specific behavioral deficits that may contribute to neurodevelopmental disorders such as ASD.

No MeSH data available.


Related in: MedlinePlus

Developmental trajectory of the arcuate fasciculus. Mean diffusivity decreases with age in both hemispheres. Deletion carriers exhibit higher mean diffusivity than controls (p < 0.005). The shaded regions represent the 95th percentile confidence interval of the lines. The slopes of the lines were not significantly different between groups. Deletion carriers with an ASD diagnosis are indicated with asterisk markers.
© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4543079&req=5

f0010: Developmental trajectory of the arcuate fasciculus. Mean diffusivity decreases with age in both hemispheres. Deletion carriers exhibit higher mean diffusivity than controls (p < 0.005). The shaded regions represent the 95th percentile confidence interval of the lines. The slopes of the lines were not significantly different between groups. Deletion carriers with an ASD diagnosis are indicated with asterisk markers.


Abnormal auditory and language pathways in children with 16p11.2 deletion.

Berman JI, Chudnovskaya D, Blaskey L, Kuschner E, Mukherjee P, Buckner R, Nagarajan S, Chung WK, Spiro JE, Sherr EH, Roberts TP - Neuroimage Clin (2015)

Developmental trajectory of the arcuate fasciculus. Mean diffusivity decreases with age in both hemispheres. Deletion carriers exhibit higher mean diffusivity than controls (p < 0.005). The shaded regions represent the 95th percentile confidence interval of the lines. The slopes of the lines were not significantly different between groups. Deletion carriers with an ASD diagnosis are indicated with asterisk markers.
© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4543079&req=5

f0010: Developmental trajectory of the arcuate fasciculus. Mean diffusivity decreases with age in both hemispheres. Deletion carriers exhibit higher mean diffusivity than controls (p < 0.005). The shaded regions represent the 95th percentile confidence interval of the lines. The slopes of the lines were not significantly different between groups. Deletion carriers with an ASD diagnosis are indicated with asterisk markers.
Bottom Line: In both tracts, deletion carriers exhibited significantly higher diffusivity than that of controls.Within deletion carriers, the left-hemisphere arcuate fasciculus mean and radial diffusivities were significantly negatively correlated with clinical language ability, but not non-verbal cognitive ability.Diffusion metrics in the right-hemisphere arcuate fasciculus were not predictive of language ability.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Children's Hospital of Philadelphia, 34th and Civic Center Blvd, Philadelphia, PA 19104, USA ; Department of Radiology, Perelman School of Medicine University of Pennsylvania, 34th and Civic Center Blvd, Philadelphia, PA 19104, USA.

ABSTRACT
Copy number variations at chromosome 16p11.2 contribute to neurodevelopmental disorders, including autism spectrum disorder (ASD). This study seeks to improve our understanding of the biological basis of behavioral phenotypes common in ASD, in particular the prominent and prevalent disruption of spoken language seen in children with the 16p11.2 BP4-BP5 deletion. We examined the auditory and language white matter pathways with diffusion MRI in a cohort of 36 pediatric deletion carriers and 45 age-matched controls. Diffusion MR tractography of the auditory radiations and the arcuate fasciculus was performed to generate tract specific measures of white matter microstructure. In both tracts, deletion carriers exhibited significantly higher diffusivity than that of controls. Cross-sectional diffusion parameters in these tracts changed with age with no group difference in the rate of maturation. Within deletion carriers, the left-hemisphere arcuate fasciculus mean and radial diffusivities were significantly negatively correlated with clinical language ability, but not non-verbal cognitive ability. Diffusion metrics in the right-hemisphere arcuate fasciculus were not predictive of language ability. These results provide insight into the link between the 16p11.2 deletion, abnormal auditory and language pathway structures, and the specific behavioral deficits that may contribute to neurodevelopmental disorders such as ASD.

No MeSH data available.


Related in: MedlinePlus