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Age cutoff in lymphoma diagnosis.

Ok CY, Young KH - Aging (Albany NY) (2015)

View Article: PubMed Central - PubMed

Affiliation: Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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Aging is characterized by immunosenescence, decreased immune response and dysregulated coordination between inflammatory and inflammation-neutralizing processes... In a young individual, there are strong supplies of cytokines including insulin-like growth factor-1, keratinocyte growth factor and interleukin-7 that induce production of naïve T-cells with a diverse T-cell receptor repertoire... When antigen is presented by antigen-presenting cells, effector T-cells and memory T-cells are quickly produced... In an aged person, there is a significant decline in the stimulatory cytokines, hence leading to a decreased T-cell population... Analysis of whole-exome sequencing data from DNA in the peripheral blood cells of 17,182 persons without hematologic malignancies showed that prevalence of somatic mutations increase with age and the cumulative incidence of hematologic cancer is quantitatively associated with presence of somatic mutations... Epigenetic alterations are also associated with development of cancer... Genome-wide alteration in methylation is extensively found with age... Prevalence of EBV positivity in DLBCL increases with age, up to 30% in patients >90 years... Our recent study showed that EBV+ DLBCL in patients >50 years are clinically and biologically similar to those ≤50 years in clinicopathologic features, immunophenotypes, gene expression profiling, microRNA profiling and treatment outcome... Immunosenescence might be an underlying predisposing factor of lymphomagenesis in EBV+ DLBCL of the elderly, but lack of difference in multiple parameters between patients >50 years and ≤50 years prevents us from using the current age cutoff in lymphoma definition and classification... We recommend that the entity be defined as EBV DLBCL and regarded as a biologically distinct variant of DLBCL... Its genomic or epigenomic aberrations and immune-regulatory defects distinguish from EBVde novo DLBCL, suggesting that these patients may benefit immunotherapy, alone and in combination, with targeted therapeutic interventions.

No MeSH data available.


Compared with an elderly, the absolute number of naïve T-cells is higher with diverse T-cell receptor repertoire in a young adult. When antigen is presented by antigen presenting cells, effector T-cells and memory T-cells are quickly produced. In an elderly, the absolute number of naïve T-cells are decreased with limited T-cell receptor repertoire. Chronically stimulated effector T-cells and memory T-cells predominate with progressive expansion of oligoclonal T-cells.
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Figure 1: Compared with an elderly, the absolute number of naïve T-cells is higher with diverse T-cell receptor repertoire in a young adult. When antigen is presented by antigen presenting cells, effector T-cells and memory T-cells are quickly produced. In an elderly, the absolute number of naïve T-cells are decreased with limited T-cell receptor repertoire. Chronically stimulated effector T-cells and memory T-cells predominate with progressive expansion of oligoclonal T-cells.


Age cutoff in lymphoma diagnosis.

Ok CY, Young KH - Aging (Albany NY) (2015)

Compared with an elderly, the absolute number of naïve T-cells is higher with diverse T-cell receptor repertoire in a young adult. When antigen is presented by antigen presenting cells, effector T-cells and memory T-cells are quickly produced. In an elderly, the absolute number of naïve T-cells are decreased with limited T-cell receptor repertoire. Chronically stimulated effector T-cells and memory T-cells predominate with progressive expansion of oligoclonal T-cells.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4543027&req=5

Figure 1: Compared with an elderly, the absolute number of naïve T-cells is higher with diverse T-cell receptor repertoire in a young adult. When antigen is presented by antigen presenting cells, effector T-cells and memory T-cells are quickly produced. In an elderly, the absolute number of naïve T-cells are decreased with limited T-cell receptor repertoire. Chronically stimulated effector T-cells and memory T-cells predominate with progressive expansion of oligoclonal T-cells.

View Article: PubMed Central - PubMed

Affiliation: Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Aging is characterized by immunosenescence, decreased immune response and dysregulated coordination between inflammatory and inflammation-neutralizing processes... In a young individual, there are strong supplies of cytokines including insulin-like growth factor-1, keratinocyte growth factor and interleukin-7 that induce production of naïve T-cells with a diverse T-cell receptor repertoire... When antigen is presented by antigen-presenting cells, effector T-cells and memory T-cells are quickly produced... In an aged person, there is a significant decline in the stimulatory cytokines, hence leading to a decreased T-cell population... Analysis of whole-exome sequencing data from DNA in the peripheral blood cells of 17,182 persons without hematologic malignancies showed that prevalence of somatic mutations increase with age and the cumulative incidence of hematologic cancer is quantitatively associated with presence of somatic mutations... Epigenetic alterations are also associated with development of cancer... Genome-wide alteration in methylation is extensively found with age... Prevalence of EBV positivity in DLBCL increases with age, up to 30% in patients >90 years... Our recent study showed that EBV+ DLBCL in patients >50 years are clinically and biologically similar to those ≤50 years in clinicopathologic features, immunophenotypes, gene expression profiling, microRNA profiling and treatment outcome... Immunosenescence might be an underlying predisposing factor of lymphomagenesis in EBV+ DLBCL of the elderly, but lack of difference in multiple parameters between patients >50 years and ≤50 years prevents us from using the current age cutoff in lymphoma definition and classification... We recommend that the entity be defined as EBV DLBCL and regarded as a biologically distinct variant of DLBCL... Its genomic or epigenomic aberrations and immune-regulatory defects distinguish from EBVde novo DLBCL, suggesting that these patients may benefit immunotherapy, alone and in combination, with targeted therapeutic interventions.

No MeSH data available.