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Reduction of multiple pregnancies in the advanced maternal age population after implementation of an elective single embryo transfer policy coupled with enhanced embryo selection: pre- and post-intervention study.

Ubaldi FM, Capalbo A, Colamaria S, Ferrero S, Maggiulli R, Vajta G, Sapienza F, Cimadomo D, Giuliani M, Gravotta E, Vaiarelli A, Rienzi L - Hum. Reprod. (2015)

Bottom Line: As shown in this study, enhanced embryo selection procedures might allow a reduction in the number of embryos transferred and the number of transfers to be performed without affecting the total efficacy of the treatment but increasing efficiency and safety.None.

View Article: PubMed Central - PubMed

Affiliation: G.EN.E.R.A. Centre for Reproductive Medicine, Clinica Valle Giulia, Via G. De Notaris 2b, 00197 Rome, Italy ubaldi.fm@gmail.com.

No MeSH data available.


Related in: MedlinePlus

Graphical representation of the results obtained after the introduction of the eSET policy. (A) Impact of the eSET policy in cumulative DR and multiple pregnancy rate (MPR) over the 4 years. While no differences are observed in cumulative DR, the MPR is significantly reduced after the intervention (P < 0.01) as assessed by logistic regression analysis adjusted for confounding factors. (B) Distribution of single, double, triple and quadruple embryo transfers (ET) before and after the intervention (P < 0.01). Differences were evaluated with Pearson's χ2 test.
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DEV159F1: Graphical representation of the results obtained after the introduction of the eSET policy. (A) Impact of the eSET policy in cumulative DR and multiple pregnancy rate (MPR) over the 4 years. While no differences are observed in cumulative DR, the MPR is significantly reduced after the intervention (P < 0.01) as assessed by logistic regression analysis adjusted for confounding factors. (B) Distribution of single, double, triple and quadruple embryo transfers (ET) before and after the intervention (P < 0.01). Differences were evaluated with Pearson's χ2 test.

Mentions: The mean number of embryos replaced per transfer (including cryopreserved cycles) decreased after the introduction of the new embryo transfer policy, from 2.9 ± 1.1 (range 1–4) and 1.4 ± 0.8 (range 1–3) (Table V). The percentage of cycles having SET increased from 21.9% per embryo transfer (407/1854) in the preintervention period to 55.9% (284/508) per transfer in post-intervention period (P < 0.01) (Fig. 1). As a result of transferring fewer embryos, the proportion of cycles where surplus oocytes or embryos were cryopreserved improved significantly from 42% (677/1609) to 57% (325/574), respectively (P < 0.01).Table V


Reduction of multiple pregnancies in the advanced maternal age population after implementation of an elective single embryo transfer policy coupled with enhanced embryo selection: pre- and post-intervention study.

Ubaldi FM, Capalbo A, Colamaria S, Ferrero S, Maggiulli R, Vajta G, Sapienza F, Cimadomo D, Giuliani M, Gravotta E, Vaiarelli A, Rienzi L - Hum. Reprod. (2015)

Graphical representation of the results obtained after the introduction of the eSET policy. (A) Impact of the eSET policy in cumulative DR and multiple pregnancy rate (MPR) over the 4 years. While no differences are observed in cumulative DR, the MPR is significantly reduced after the intervention (P < 0.01) as assessed by logistic regression analysis adjusted for confounding factors. (B) Distribution of single, double, triple and quadruple embryo transfers (ET) before and after the intervention (P < 0.01). Differences were evaluated with Pearson's χ2 test.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4542718&req=5

DEV159F1: Graphical representation of the results obtained after the introduction of the eSET policy. (A) Impact of the eSET policy in cumulative DR and multiple pregnancy rate (MPR) over the 4 years. While no differences are observed in cumulative DR, the MPR is significantly reduced after the intervention (P < 0.01) as assessed by logistic regression analysis adjusted for confounding factors. (B) Distribution of single, double, triple and quadruple embryo transfers (ET) before and after the intervention (P < 0.01). Differences were evaluated with Pearson's χ2 test.
Mentions: The mean number of embryos replaced per transfer (including cryopreserved cycles) decreased after the introduction of the new embryo transfer policy, from 2.9 ± 1.1 (range 1–4) and 1.4 ± 0.8 (range 1–3) (Table V). The percentage of cycles having SET increased from 21.9% per embryo transfer (407/1854) in the preintervention period to 55.9% (284/508) per transfer in post-intervention period (P < 0.01) (Fig. 1). As a result of transferring fewer embryos, the proportion of cycles where surplus oocytes or embryos were cryopreserved improved significantly from 42% (677/1609) to 57% (325/574), respectively (P < 0.01).Table V

Bottom Line: As shown in this study, enhanced embryo selection procedures might allow a reduction in the number of embryos transferred and the number of transfers to be performed without affecting the total efficacy of the treatment but increasing efficiency and safety.None.

View Article: PubMed Central - PubMed

Affiliation: G.EN.E.R.A. Centre for Reproductive Medicine, Clinica Valle Giulia, Via G. De Notaris 2b, 00197 Rome, Italy ubaldi.fm@gmail.com.

No MeSH data available.


Related in: MedlinePlus