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Intracranial Carotid Calcification on Cranial Computed Tomography: Visual Scoring Methods, Semiautomated Scores, and Volume Measurements in Patients With Stroke.

Subedi D, Zishan US, Chappell F, Gregoriades ML, Sudlow C, Sellar R, Wardlaw J - Stroke (2015)

Bottom Line: Intracranial internal carotid artery calcification increased with age by all measures (eg, visual score, Spearman ρ=0.4; P=0.005).Visual scores correlate highly with quantitative intracranial internal carotid artery calcification measures, with excellent observer agreements.Visual intracranial internal carotid artery scores could be a rapid and practical method for epidemiological studies.

View Article: PubMed Central - PubMed

Affiliation: From the Department of Clinical Radiology, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom (D.S., U.S.Z., M.-L.G.); Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom (F.C., C.S., R.S., J.W.); and Brain Research Imaging Centre, Scottish Imaging Network-A Platform for Scientific Excellence (SINAPSE) Collaboration, Edinburgh, United Kingdom (R.S., J.W.).

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A, Modified Woodcock visual score vs Agatston score: R2=0.83, P<0.0001 (cube root–transformed linear plot; Figure IIIA in the online-only Data Supplement). B, Modified Woodcock visual score vs calcium volume: R2=0.84, P<0.0001 (cube root–transformed linear plot; Figure IIIB in the online-only Data Supplement).
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Figure 2: A, Modified Woodcock visual score vs Agatston score: R2=0.83, P<0.0001 (cube root–transformed linear plot; Figure IIIA in the online-only Data Supplement). B, Modified Woodcock visual score vs calcium volume: R2=0.84, P<0.0001 (cube root–transformed linear plot; Figure IIIB in the online-only Data Supplement).

Mentions: The Woodcock visual score correlated well with (Table 2) the Agatston score (right: Spearman ρ=0.81, P=0.01 and left: Spearman ρ=0.79; P=0.01), calcium volume (right: Spearman ρ=0.81; P=0.01 and left: Spearman ρ=0.80; P=0.01), and modified Woodcock score (Figures I and II in the online-only Data Supplement; right: Spearman ρ=0.81; P=0.01 and left: Spearman ρ=0.83; P=0.01). The total modified Woodcock visual score (combined left and right) also correlated well with total Agatston score and total calcium volume (Figure 2; Spearman ρ=0.89; P=0.01 and Spearman ρ=0.91; P=0.01, respectively). The cube root transformation of Agatston score and calcium volume successfully linearized the relationships with the modified Woodcock visual score (Figure IIIA and IIIB in the online-only Data Supplement). All linear regression model diagnostics were satisfactory. This translated to an increase in calcium volume of 0.476 mm (95% confidence interval, 0.368–0.466; P<0.0001) for each point increase in the modified Woodcock visual score.


Intracranial Carotid Calcification on Cranial Computed Tomography: Visual Scoring Methods, Semiautomated Scores, and Volume Measurements in Patients With Stroke.

Subedi D, Zishan US, Chappell F, Gregoriades ML, Sudlow C, Sellar R, Wardlaw J - Stroke (2015)

A, Modified Woodcock visual score vs Agatston score: R2=0.83, P<0.0001 (cube root–transformed linear plot; Figure IIIA in the online-only Data Supplement). B, Modified Woodcock visual score vs calcium volume: R2=0.84, P<0.0001 (cube root–transformed linear plot; Figure IIIB in the online-only Data Supplement).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4542564&req=5

Figure 2: A, Modified Woodcock visual score vs Agatston score: R2=0.83, P<0.0001 (cube root–transformed linear plot; Figure IIIA in the online-only Data Supplement). B, Modified Woodcock visual score vs calcium volume: R2=0.84, P<0.0001 (cube root–transformed linear plot; Figure IIIB in the online-only Data Supplement).
Mentions: The Woodcock visual score correlated well with (Table 2) the Agatston score (right: Spearman ρ=0.81, P=0.01 and left: Spearman ρ=0.79; P=0.01), calcium volume (right: Spearman ρ=0.81; P=0.01 and left: Spearman ρ=0.80; P=0.01), and modified Woodcock score (Figures I and II in the online-only Data Supplement; right: Spearman ρ=0.81; P=0.01 and left: Spearman ρ=0.83; P=0.01). The total modified Woodcock visual score (combined left and right) also correlated well with total Agatston score and total calcium volume (Figure 2; Spearman ρ=0.89; P=0.01 and Spearman ρ=0.91; P=0.01, respectively). The cube root transformation of Agatston score and calcium volume successfully linearized the relationships with the modified Woodcock visual score (Figure IIIA and IIIB in the online-only Data Supplement). All linear regression model diagnostics were satisfactory. This translated to an increase in calcium volume of 0.476 mm (95% confidence interval, 0.368–0.466; P<0.0001) for each point increase in the modified Woodcock visual score.

Bottom Line: Intracranial internal carotid artery calcification increased with age by all measures (eg, visual score, Spearman ρ=0.4; P=0.005).Visual scores correlate highly with quantitative intracranial internal carotid artery calcification measures, with excellent observer agreements.Visual intracranial internal carotid artery scores could be a rapid and practical method for epidemiological studies.

View Article: PubMed Central - PubMed

Affiliation: From the Department of Clinical Radiology, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom (D.S., U.S.Z., M.-L.G.); Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom (F.C., C.S., R.S., J.W.); and Brain Research Imaging Centre, Scottish Imaging Network-A Platform for Scientific Excellence (SINAPSE) Collaboration, Edinburgh, United Kingdom (R.S., J.W.).

Show MeSH
Related in: MedlinePlus