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Genetic Architecture of Lacunar Stroke.

Traylor M, Bevan S, Baron JC, Hassan A, Lewis CM, Markus HS - Stroke (2015)

Bottom Line: This heritable component is significantly enriched for sites affecting expression of genes.Much of this heritability arises from regions of the genome affecting gene regulation.Rare variation affects 2 subtypes of lacunar in isolation, suggesting that they may have distinct genetic susceptibility factors.

View Article: PubMed Central - PubMed

Affiliation: From the Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom (M.T., S.B., H.S.M.); Department of Neurology, Université Paris Descartes Sorbonne Paris Cité, Centre de Psychiatrie et Neurosciences, Institut National de la Santé et de la Recherche Médicale S894, Centre Hospitalier Sainte-Anne, Paris, France (J.-C.B.); Department of Neurology, Leeds General Infirmary, Leeds, United Kingdom (A.H.); Department of Medical and Molecular Genetics, King's College London, London, United Kingdom (C.M.L.); and MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom (C.M.L.). mt628@medschl.cam.ac.uk.

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Proportion of overall heritability explained by expression quantitative trait loci (eQTLs) and regulatory regions for lacunar stroke and its subtypes, with horizontal line indicating the expected proportion of heritability for the number of single-nucleotide polymorphisms included in analysis. ILI indicates isolated lacunar infarct; LA, leukoaraiosis; and MLI, multiple lacunar infarcts.
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Figure 1: Proportion of overall heritability explained by expression quantitative trait loci (eQTLs) and regulatory regions for lacunar stroke and its subtypes, with horizontal line indicating the expected proportion of heritability for the number of single-nucleotide polymorphisms included in analysis. ILI indicates isolated lacunar infarct; LA, leukoaraiosis; and MLI, multiple lacunar infarcts.


Genetic Architecture of Lacunar Stroke.

Traylor M, Bevan S, Baron JC, Hassan A, Lewis CM, Markus HS - Stroke (2015)

Proportion of overall heritability explained by expression quantitative trait loci (eQTLs) and regulatory regions for lacunar stroke and its subtypes, with horizontal line indicating the expected proportion of heritability for the number of single-nucleotide polymorphisms included in analysis. ILI indicates isolated lacunar infarct; LA, leukoaraiosis; and MLI, multiple lacunar infarcts.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4542563&req=5

Figure 1: Proportion of overall heritability explained by expression quantitative trait loci (eQTLs) and regulatory regions for lacunar stroke and its subtypes, with horizontal line indicating the expected proportion of heritability for the number of single-nucleotide polymorphisms included in analysis. ILI indicates isolated lacunar infarct; LA, leukoaraiosis; and MLI, multiple lacunar infarcts.
Bottom Line: This heritable component is significantly enriched for sites affecting expression of genes.Much of this heritability arises from regions of the genome affecting gene regulation.Rare variation affects 2 subtypes of lacunar in isolation, suggesting that they may have distinct genetic susceptibility factors.

View Article: PubMed Central - PubMed

Affiliation: From the Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom (M.T., S.B., H.S.M.); Department of Neurology, Université Paris Descartes Sorbonne Paris Cité, Centre de Psychiatrie et Neurosciences, Institut National de la Santé et de la Recherche Médicale S894, Centre Hospitalier Sainte-Anne, Paris, France (J.-C.B.); Department of Neurology, Leeds General Infirmary, Leeds, United Kingdom (A.H.); Department of Medical and Molecular Genetics, King's College London, London, United Kingdom (C.M.L.); and MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom (C.M.L.). mt628@medschl.cam.ac.uk.

Show MeSH
Related in: MedlinePlus