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Saccharomyces boulardii CNCM I-745 supports regeneration of the intestinal microbiota after diarrheic dysbiosis - a review.

Moré MI, Swidsinski A - Clin Exp Gastroenterol (2015)

Bottom Line: Its action is based on multiple mechanisms, including immunological effects, pathogen-binding and antitoxinic effects, as well as effects on digestive enzymes.The previously observed preventive action of S. boulardii, eg, during antibiotic therapy or regarding traveler's diarrhea, can be explained by several mechanisms, including a stabilizing effect on the healthy microbiota as well as possibly on the mucus layer.Several different dysbiotic situations could profit from the effects of S. boulardii CNCM I-745.

View Article: PubMed Central - PubMed

Affiliation: analyze & realize GmbH, Berlin, Germany.

ABSTRACT
The probiotic medicinal yeast Saccharomyces cerevisiae HANSEN CBS 5926 (Saccharomyces boulardii CNCM I-745) is used for the prevention and treatment of diarrhea. Its action is based on multiple mechanisms, including immunological effects, pathogen-binding and antitoxinic effects, as well as effects on digestive enzymes. Correlated with these effects, but also due to its inherent properties, S. boulardii is able to create a favorable growth environment for the beneficial intestinal microbiota, while constituting extra protection to the host mucus layer and mucosa. This review focuses on the positive influence of S. boulardii on the composition of the intestinal microbiota. In a dysbiosis, as during diarrhea, the main microbial population (especially Lachnospiraceae, Ruminococcaceae, Bacteroidaceae, and Prevotellaceae) is known to collapse by at least one order of magnitude. This gap generally leads to transient increases in pioneer-type bacteria (Enterobacteriaceae, Bifidobacteriaceae, and Clostridiaceae). Several human studies as well as animal models demonstrate that treatment with S. boulardii in dysbiosis leads to the faster reestablishment of a healthy microbiome. The most relevant effects of S. boulardii on the fecal composition include an increase of short chain fatty acid-producing bacteria (along with a rise in short chain fatty acids), especially of Lachnospiraceae and Ruminococcaceae, as well as an increase in Bacteroidaceae and Prevotellaceae. At the same time, there is a suppression of pioneer bacteria. The previously observed preventive action of S. boulardii, eg, during antibiotic therapy or regarding traveler's diarrhea, can be explained by several mechanisms, including a stabilizing effect on the healthy microbiota as well as possibly on the mucus layer. Several different dysbiotic situations could profit from the effects of S. boulardii CNCM I-745. Its additional potential lies in a general stabilization of the gut flora for at-risk populations. More studies are needed to explore the full potential of this versatile probiotic yeast.

No MeSH data available.


Related in: MedlinePlus

Dysbiosis of intestinal microbiota during diarrhea.Notes: The gastrointestinal tract harbors a complex microbial ecosystem that coexists in equilibrium with the host. When this equilibrium is disrupted, dysbiosis can manifest itself in a vicious cycle, prolonging diarrheic symptoms.
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f1-ceg-8-237: Dysbiosis of intestinal microbiota during diarrhea.Notes: The gastrointestinal tract harbors a complex microbial ecosystem that coexists in equilibrium with the host. When this equilibrium is disrupted, dysbiosis can manifest itself in a vicious cycle, prolonging diarrheic symptoms.

Mentions: Several conditions may lead to a dysbiosis; in addition, there are certain risk factors, eg, malnutrition, old age, diabetes/metabolic syndrome,21,22 and stress, that additionally destabilize the microbiota (Figure 1).


Saccharomyces boulardii CNCM I-745 supports regeneration of the intestinal microbiota after diarrheic dysbiosis - a review.

Moré MI, Swidsinski A - Clin Exp Gastroenterol (2015)

Dysbiosis of intestinal microbiota during diarrhea.Notes: The gastrointestinal tract harbors a complex microbial ecosystem that coexists in equilibrium with the host. When this equilibrium is disrupted, dysbiosis can manifest itself in a vicious cycle, prolonging diarrheic symptoms.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4542552&req=5

f1-ceg-8-237: Dysbiosis of intestinal microbiota during diarrhea.Notes: The gastrointestinal tract harbors a complex microbial ecosystem that coexists in equilibrium with the host. When this equilibrium is disrupted, dysbiosis can manifest itself in a vicious cycle, prolonging diarrheic symptoms.
Mentions: Several conditions may lead to a dysbiosis; in addition, there are certain risk factors, eg, malnutrition, old age, diabetes/metabolic syndrome,21,22 and stress, that additionally destabilize the microbiota (Figure 1).

Bottom Line: Its action is based on multiple mechanisms, including immunological effects, pathogen-binding and antitoxinic effects, as well as effects on digestive enzymes.The previously observed preventive action of S. boulardii, eg, during antibiotic therapy or regarding traveler's diarrhea, can be explained by several mechanisms, including a stabilizing effect on the healthy microbiota as well as possibly on the mucus layer.Several different dysbiotic situations could profit from the effects of S. boulardii CNCM I-745.

View Article: PubMed Central - PubMed

Affiliation: analyze & realize GmbH, Berlin, Germany.

ABSTRACT
The probiotic medicinal yeast Saccharomyces cerevisiae HANSEN CBS 5926 (Saccharomyces boulardii CNCM I-745) is used for the prevention and treatment of diarrhea. Its action is based on multiple mechanisms, including immunological effects, pathogen-binding and antitoxinic effects, as well as effects on digestive enzymes. Correlated with these effects, but also due to its inherent properties, S. boulardii is able to create a favorable growth environment for the beneficial intestinal microbiota, while constituting extra protection to the host mucus layer and mucosa. This review focuses on the positive influence of S. boulardii on the composition of the intestinal microbiota. In a dysbiosis, as during diarrhea, the main microbial population (especially Lachnospiraceae, Ruminococcaceae, Bacteroidaceae, and Prevotellaceae) is known to collapse by at least one order of magnitude. This gap generally leads to transient increases in pioneer-type bacteria (Enterobacteriaceae, Bifidobacteriaceae, and Clostridiaceae). Several human studies as well as animal models demonstrate that treatment with S. boulardii in dysbiosis leads to the faster reestablishment of a healthy microbiome. The most relevant effects of S. boulardii on the fecal composition include an increase of short chain fatty acid-producing bacteria (along with a rise in short chain fatty acids), especially of Lachnospiraceae and Ruminococcaceae, as well as an increase in Bacteroidaceae and Prevotellaceae. At the same time, there is a suppression of pioneer bacteria. The previously observed preventive action of S. boulardii, eg, during antibiotic therapy or regarding traveler's diarrhea, can be explained by several mechanisms, including a stabilizing effect on the healthy microbiota as well as possibly on the mucus layer. Several different dysbiotic situations could profit from the effects of S. boulardii CNCM I-745. Its additional potential lies in a general stabilization of the gut flora for at-risk populations. More studies are needed to explore the full potential of this versatile probiotic yeast.

No MeSH data available.


Related in: MedlinePlus