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Mangrove rare actinobacteria: taxonomy, natural compound, and discovery of bioactivity.

Azman AS, Othman I, Velu SS, Chan KG, Lee LH - Front Microbiol (2015)

Bottom Line: As a result, there is a dramatic increase in demand to look for new compounds which have pharmacological properties from another group of Actinobacteria, known as rare actinobacteria; which is isolated from special environments such as mangrove.Many novel compounds discovered from the novel rare actinobacteria have been proven as potential new drugs in medical and pharmaceutical industries such as antibiotics, antimicrobials, antibacterials, anticancer, and antifungals.This review article highlights the latest studies on the discovery of natural compounds from the novel mangrove rare actinobacteria and provides insight on the impact of these findings.

View Article: PubMed Central - PubMed

Affiliation: Jeffrey Cheah School of Medicine and Health Sciences, Monash University Sunway Campus Selangor, Malaysia.

ABSTRACT
Actinobacteria are one of the most important and efficient groups of natural metabolite producers. The genus Streptomyces have been recognized as prolific producers of useful natural compounds as they produced more than half of the naturally-occurring antibiotics isolated to-date and continue as the primary source of new bioactive compounds. Lately, Streptomyces groups isolated from different environments produced the same types of compound, possibly due to frequent genetic exchanges between species. As a result, there is a dramatic increase in demand to look for new compounds which have pharmacological properties from another group of Actinobacteria, known as rare actinobacteria; which is isolated from special environments such as mangrove. Recently, mangrove ecosystem is becoming a hot spot for studies of bioactivities and the discovery of natural products. Many novel compounds discovered from the novel rare actinobacteria have been proven as potential new drugs in medical and pharmaceutical industries such as antibiotics, antimicrobials, antibacterials, anticancer, and antifungals. This review article highlights the latest studies on the discovery of natural compounds from the novel mangrove rare actinobacteria and provides insight on the impact of these findings.

No MeSH data available.


Related in: MedlinePlus

The structure of Nocardiatones A (27), B (28), and C (29).
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Figure 6: The structure of Nocardiatones A (27), B (28), and C (29).

Mentions: Nocardiopsis species were known to produce bioactive metabolites. Researchers discovered Nocardiopsis species were able to produce griseusin (Sun et al., 1991), apoptolidin (Kim et al., 1997), methylpendolmycin (Li et al., 2007a), thiopeptide (designated TP-1161) (Gandhimathi et al., 2009), lipopeptide biosurfactant (Ding et al., 2010), and napthhospironone A (Engelhardt et al., 2010). Three new 2-pyranone derivatives known as Nocardiatones A (27), B (28), and C (29) (Figure 6) were discovered from novel mangrove endophytic, Nocadiopsis sp. A00203 (Lin et al., 2010). This species was isolated from the leaves of Aegiceras corniculatum (Myrsinaceae). The structures of all compounds were examined using spectroscopic and mass-spectrometric analyses. The analysis of the anticancer activity of the compound was performed using HeLa cells and only Nocardiatones A showed weak cytotoxic activity against HeLa cells. No inhibition was observed, when these compounds were tested on Escherichia coli, Bacillus subtilis, Staphylococcus aureus, and yeasts.


Mangrove rare actinobacteria: taxonomy, natural compound, and discovery of bioactivity.

Azman AS, Othman I, Velu SS, Chan KG, Lee LH - Front Microbiol (2015)

The structure of Nocardiatones A (27), B (28), and C (29).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4542535&req=5

Figure 6: The structure of Nocardiatones A (27), B (28), and C (29).
Mentions: Nocardiopsis species were known to produce bioactive metabolites. Researchers discovered Nocardiopsis species were able to produce griseusin (Sun et al., 1991), apoptolidin (Kim et al., 1997), methylpendolmycin (Li et al., 2007a), thiopeptide (designated TP-1161) (Gandhimathi et al., 2009), lipopeptide biosurfactant (Ding et al., 2010), and napthhospironone A (Engelhardt et al., 2010). Three new 2-pyranone derivatives known as Nocardiatones A (27), B (28), and C (29) (Figure 6) were discovered from novel mangrove endophytic, Nocadiopsis sp. A00203 (Lin et al., 2010). This species was isolated from the leaves of Aegiceras corniculatum (Myrsinaceae). The structures of all compounds were examined using spectroscopic and mass-spectrometric analyses. The analysis of the anticancer activity of the compound was performed using HeLa cells and only Nocardiatones A showed weak cytotoxic activity against HeLa cells. No inhibition was observed, when these compounds were tested on Escherichia coli, Bacillus subtilis, Staphylococcus aureus, and yeasts.

Bottom Line: As a result, there is a dramatic increase in demand to look for new compounds which have pharmacological properties from another group of Actinobacteria, known as rare actinobacteria; which is isolated from special environments such as mangrove.Many novel compounds discovered from the novel rare actinobacteria have been proven as potential new drugs in medical and pharmaceutical industries such as antibiotics, antimicrobials, antibacterials, anticancer, and antifungals.This review article highlights the latest studies on the discovery of natural compounds from the novel mangrove rare actinobacteria and provides insight on the impact of these findings.

View Article: PubMed Central - PubMed

Affiliation: Jeffrey Cheah School of Medicine and Health Sciences, Monash University Sunway Campus Selangor, Malaysia.

ABSTRACT
Actinobacteria are one of the most important and efficient groups of natural metabolite producers. The genus Streptomyces have been recognized as prolific producers of useful natural compounds as they produced more than half of the naturally-occurring antibiotics isolated to-date and continue as the primary source of new bioactive compounds. Lately, Streptomyces groups isolated from different environments produced the same types of compound, possibly due to frequent genetic exchanges between species. As a result, there is a dramatic increase in demand to look for new compounds which have pharmacological properties from another group of Actinobacteria, known as rare actinobacteria; which is isolated from special environments such as mangrove. Recently, mangrove ecosystem is becoming a hot spot for studies of bioactivities and the discovery of natural products. Many novel compounds discovered from the novel rare actinobacteria have been proven as potential new drugs in medical and pharmaceutical industries such as antibiotics, antimicrobials, antibacterials, anticancer, and antifungals. This review article highlights the latest studies on the discovery of natural compounds from the novel mangrove rare actinobacteria and provides insight on the impact of these findings.

No MeSH data available.


Related in: MedlinePlus