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Mangrove rare actinobacteria: taxonomy, natural compound, and discovery of bioactivity.

Azman AS, Othman I, Velu SS, Chan KG, Lee LH - Front Microbiol (2015)

Bottom Line: As a result, there is a dramatic increase in demand to look for new compounds which have pharmacological properties from another group of Actinobacteria, known as rare actinobacteria; which is isolated from special environments such as mangrove.Many novel compounds discovered from the novel rare actinobacteria have been proven as potential new drugs in medical and pharmaceutical industries such as antibiotics, antimicrobials, antibacterials, anticancer, and antifungals.This review article highlights the latest studies on the discovery of natural compounds from the novel mangrove rare actinobacteria and provides insight on the impact of these findings.

View Article: PubMed Central - PubMed

Affiliation: Jeffrey Cheah School of Medicine and Health Sciences, Monash University Sunway Campus Selangor, Malaysia.

ABSTRACT
Actinobacteria are one of the most important and efficient groups of natural metabolite producers. The genus Streptomyces have been recognized as prolific producers of useful natural compounds as they produced more than half of the naturally-occurring antibiotics isolated to-date and continue as the primary source of new bioactive compounds. Lately, Streptomyces groups isolated from different environments produced the same types of compound, possibly due to frequent genetic exchanges between species. As a result, there is a dramatic increase in demand to look for new compounds which have pharmacological properties from another group of Actinobacteria, known as rare actinobacteria; which is isolated from special environments such as mangrove. Recently, mangrove ecosystem is becoming a hot spot for studies of bioactivities and the discovery of natural products. Many novel compounds discovered from the novel rare actinobacteria have been proven as potential new drugs in medical and pharmaceutical industries such as antibiotics, antimicrobials, antibacterials, anticancer, and antifungals. This review article highlights the latest studies on the discovery of natural compounds from the novel mangrove rare actinobacteria and provides insight on the impact of these findings.

No MeSH data available.


Related in: MedlinePlus

The structure of Salinosporamide A (25).
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Figure 4: The structure of Salinosporamide A (25).

Mentions: A significant feature of Salinispora tropica is its ability to produce structurally unique secondary metabolites. Feling et al. (2003) reported that the Salinispora tropica CNB-392 isolated from a mangrove area in Chub Cay, Bahamas produced a unique metabolite named salinosporamide A (25) (Figure 4) attached with γ-lactam-β-lactone bicyclic core with clasto-lactacystin-β-lactone (also called as omuralide), a metabolite discovered from terrestrial Streptomyces sp. The study showed that this compound was able to kill different degrees of cancer cells and possessed strong inhibition of the 20S proteasome. Salinosporamide A was tested for the effects on proteasome function due to its structural relationship to omuralide. Results exhibited that Salinosporamide A was 35 times more potent compared to omuralide. Currently, the Salinosporamide A is in phase I human clinical trials as a potential anticancer drug (Fenical et al., 2009).


Mangrove rare actinobacteria: taxonomy, natural compound, and discovery of bioactivity.

Azman AS, Othman I, Velu SS, Chan KG, Lee LH - Front Microbiol (2015)

The structure of Salinosporamide A (25).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4542535&req=5

Figure 4: The structure of Salinosporamide A (25).
Mentions: A significant feature of Salinispora tropica is its ability to produce structurally unique secondary metabolites. Feling et al. (2003) reported that the Salinispora tropica CNB-392 isolated from a mangrove area in Chub Cay, Bahamas produced a unique metabolite named salinosporamide A (25) (Figure 4) attached with γ-lactam-β-lactone bicyclic core with clasto-lactacystin-β-lactone (also called as omuralide), a metabolite discovered from terrestrial Streptomyces sp. The study showed that this compound was able to kill different degrees of cancer cells and possessed strong inhibition of the 20S proteasome. Salinosporamide A was tested for the effects on proteasome function due to its structural relationship to omuralide. Results exhibited that Salinosporamide A was 35 times more potent compared to omuralide. Currently, the Salinosporamide A is in phase I human clinical trials as a potential anticancer drug (Fenical et al., 2009).

Bottom Line: As a result, there is a dramatic increase in demand to look for new compounds which have pharmacological properties from another group of Actinobacteria, known as rare actinobacteria; which is isolated from special environments such as mangrove.Many novel compounds discovered from the novel rare actinobacteria have been proven as potential new drugs in medical and pharmaceutical industries such as antibiotics, antimicrobials, antibacterials, anticancer, and antifungals.This review article highlights the latest studies on the discovery of natural compounds from the novel mangrove rare actinobacteria and provides insight on the impact of these findings.

View Article: PubMed Central - PubMed

Affiliation: Jeffrey Cheah School of Medicine and Health Sciences, Monash University Sunway Campus Selangor, Malaysia.

ABSTRACT
Actinobacteria are one of the most important and efficient groups of natural metabolite producers. The genus Streptomyces have been recognized as prolific producers of useful natural compounds as they produced more than half of the naturally-occurring antibiotics isolated to-date and continue as the primary source of new bioactive compounds. Lately, Streptomyces groups isolated from different environments produced the same types of compound, possibly due to frequent genetic exchanges between species. As a result, there is a dramatic increase in demand to look for new compounds which have pharmacological properties from another group of Actinobacteria, known as rare actinobacteria; which is isolated from special environments such as mangrove. Recently, mangrove ecosystem is becoming a hot spot for studies of bioactivities and the discovery of natural products. Many novel compounds discovered from the novel rare actinobacteria have been proven as potential new drugs in medical and pharmaceutical industries such as antibiotics, antimicrobials, antibacterials, anticancer, and antifungals. This review article highlights the latest studies on the discovery of natural compounds from the novel mangrove rare actinobacteria and provides insight on the impact of these findings.

No MeSH data available.


Related in: MedlinePlus