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Mangrove rare actinobacteria: taxonomy, natural compound, and discovery of bioactivity.

Azman AS, Othman I, Velu SS, Chan KG, Lee LH - Front Microbiol (2015)

Bottom Line: As a result, there is a dramatic increase in demand to look for new compounds which have pharmacological properties from another group of Actinobacteria, known as rare actinobacteria; which is isolated from special environments such as mangrove.Many novel compounds discovered from the novel rare actinobacteria have been proven as potential new drugs in medical and pharmaceutical industries such as antibiotics, antimicrobials, antibacterials, anticancer, and antifungals.This review article highlights the latest studies on the discovery of natural compounds from the novel mangrove rare actinobacteria and provides insight on the impact of these findings.

View Article: PubMed Central - PubMed

Affiliation: Jeffrey Cheah School of Medicine and Health Sciences, Monash University Sunway Campus Selangor, Malaysia.

ABSTRACT
Actinobacteria are one of the most important and efficient groups of natural metabolite producers. The genus Streptomyces have been recognized as prolific producers of useful natural compounds as they produced more than half of the naturally-occurring antibiotics isolated to-date and continue as the primary source of new bioactive compounds. Lately, Streptomyces groups isolated from different environments produced the same types of compound, possibly due to frequent genetic exchanges between species. As a result, there is a dramatic increase in demand to look for new compounds which have pharmacological properties from another group of Actinobacteria, known as rare actinobacteria; which is isolated from special environments such as mangrove. Recently, mangrove ecosystem is becoming a hot spot for studies of bioactivities and the discovery of natural products. Many novel compounds discovered from the novel rare actinobacteria have been proven as potential new drugs in medical and pharmaceutical industries such as antibiotics, antimicrobials, antibacterials, anticancer, and antifungals. This review article highlights the latest studies on the discovery of natural compounds from the novel mangrove rare actinobacteria and provides insight on the impact of these findings.

No MeSH data available.


Related in: MedlinePlus

The structure of butremycin (3) and protonated aromatic tautomer of 5′-methylthioinosine (MTI) (4).
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Figure 2: The structure of butremycin (3) and protonated aromatic tautomer of 5′-methylthioinosine (MTI) (4).

Mentions: Kyeremeh et al. (2014) discovered an actinobacterial strain, Micromonospora sp. K310, from Ghanaian mangrove river sediment. The spectroscopy study of this strain led to the discovery of two new compounds (Figure 2), butremycin (3) (the (3-hydroxyl) derivative of ikarugamycin) and protonated aromatic tautomer of 5′-methylthioinosine (MTI) (4). The antibacterial activity for butremycin showed it was not potent enough to kill pathogens such as Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, and clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA) strains. The antimicrobial activity of the protonated aromatic tautomer of 5′-methylthioinosine showed no antibacterial activity against these pathogens.


Mangrove rare actinobacteria: taxonomy, natural compound, and discovery of bioactivity.

Azman AS, Othman I, Velu SS, Chan KG, Lee LH - Front Microbiol (2015)

The structure of butremycin (3) and protonated aromatic tautomer of 5′-methylthioinosine (MTI) (4).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4542535&req=5

Figure 2: The structure of butremycin (3) and protonated aromatic tautomer of 5′-methylthioinosine (MTI) (4).
Mentions: Kyeremeh et al. (2014) discovered an actinobacterial strain, Micromonospora sp. K310, from Ghanaian mangrove river sediment. The spectroscopy study of this strain led to the discovery of two new compounds (Figure 2), butremycin (3) (the (3-hydroxyl) derivative of ikarugamycin) and protonated aromatic tautomer of 5′-methylthioinosine (MTI) (4). The antibacterial activity for butremycin showed it was not potent enough to kill pathogens such as Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, and clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA) strains. The antimicrobial activity of the protonated aromatic tautomer of 5′-methylthioinosine showed no antibacterial activity against these pathogens.

Bottom Line: As a result, there is a dramatic increase in demand to look for new compounds which have pharmacological properties from another group of Actinobacteria, known as rare actinobacteria; which is isolated from special environments such as mangrove.Many novel compounds discovered from the novel rare actinobacteria have been proven as potential new drugs in medical and pharmaceutical industries such as antibiotics, antimicrobials, antibacterials, anticancer, and antifungals.This review article highlights the latest studies on the discovery of natural compounds from the novel mangrove rare actinobacteria and provides insight on the impact of these findings.

View Article: PubMed Central - PubMed

Affiliation: Jeffrey Cheah School of Medicine and Health Sciences, Monash University Sunway Campus Selangor, Malaysia.

ABSTRACT
Actinobacteria are one of the most important and efficient groups of natural metabolite producers. The genus Streptomyces have been recognized as prolific producers of useful natural compounds as they produced more than half of the naturally-occurring antibiotics isolated to-date and continue as the primary source of new bioactive compounds. Lately, Streptomyces groups isolated from different environments produced the same types of compound, possibly due to frequent genetic exchanges between species. As a result, there is a dramatic increase in demand to look for new compounds which have pharmacological properties from another group of Actinobacteria, known as rare actinobacteria; which is isolated from special environments such as mangrove. Recently, mangrove ecosystem is becoming a hot spot for studies of bioactivities and the discovery of natural products. Many novel compounds discovered from the novel rare actinobacteria have been proven as potential new drugs in medical and pharmaceutical industries such as antibiotics, antimicrobials, antibacterials, anticancer, and antifungals. This review article highlights the latest studies on the discovery of natural compounds from the novel mangrove rare actinobacteria and provides insight on the impact of these findings.

No MeSH data available.


Related in: MedlinePlus