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The effect of age on cognitive performance of frontal patients.

Cipolotti L, Healy C, Chan E, MacPherson SE, White M, Woollett K, Turner M, Robinson G, Spanò B, Bozzali M, Shallice T - Neuropsychologia (2015)

Bottom Line: We found that only age consistently predicted the exacerbated executive impairment.Our results are in line with the notion that the frontal cortex plays a critical role in aging to counteract cognitive and neuronal decline.We suggest that the combined effect of aging and frontal lesions impairs the frontal cortical systems by causing its computational power to fall below the threshold needed to complete executive tasks successfully.

View Article: PubMed Central - PubMed

Affiliation: Department of Neuropsychology, National Hospital for Neurology and Neurosurgery, London, UK; Dipartimento di Psicologia, Università di Palermo, Italy. Electronic address: l.cipolotti@ucl.ac.uk.

No MeSH data available.


Related in: MedlinePlus

Means and standard deviations for the younger, middle-aged and older frontal patients (blue line) and healthy controls (purple line) on the executive test. Legend: error bars represent ±1 standard deviation. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)
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f0010: Means and standard deviations for the younger, middle-aged and older frontal patients (blue line) and healthy controls (purple line) on the executive test. Legend: error bars represent ±1 standard deviation. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)

Mentions: There was also a significant main effect of age group on both tasks (F (2, 112)=7.907, p=.001; F (2, 84)=8.267, p=.001, α=.05 respectively). We found a marginal interaction between participant group and age group on the RAPM (F (2, 112)=2.917, p=.058, α=.05) and a significant interaction on the Stroop test (F (2, 84)=4.998, p=.009, α=.05). Post-hoc analysis revealed that older participants performed significantly more poorly than younger participants (RAPM; p<.001; Stroop test: p=.001, α=.017, respectively). Middle-aged participants tended to perform more poorly than younger participants on the RAPM and Stroop tests (p=.038 and p=.021, α=.017, respectively). Age group significantly affected the performance of frontal patients on the RAPM and Stroop test (F (2, 112)=11.157, p<.001; F (2, 84)=11.915, p<.001, α=.017 respectively), but not in HC (F (2, 112)=1.490, p=.230; F (2, 84)=0.777, p=.463, α=.017 respectively). We performed post-hoc simple effects analyses and found that middle-aged and older frontal patients performed significantly more poorly than their HC counterparts (RAPM: p=.001 and p=.01 α=.017, respectively; Stroop test: p<.001 and p=.005 α=.017, respectively) and significantly more poorly than younger patients (RAPM: p=.016 and p<.001, α=.017 respectively; Stroop test: p=.001 and p<.001, α=.017, respectively; see Fig. 2).


The effect of age on cognitive performance of frontal patients.

Cipolotti L, Healy C, Chan E, MacPherson SE, White M, Woollett K, Turner M, Robinson G, Spanò B, Bozzali M, Shallice T - Neuropsychologia (2015)

Means and standard deviations for the younger, middle-aged and older frontal patients (blue line) and healthy controls (purple line) on the executive test. Legend: error bars represent ±1 standard deviation. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)
© Copyright Policy - CC BY
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4542524&req=5

f0010: Means and standard deviations for the younger, middle-aged and older frontal patients (blue line) and healthy controls (purple line) on the executive test. Legend: error bars represent ±1 standard deviation. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)
Mentions: There was also a significant main effect of age group on both tasks (F (2, 112)=7.907, p=.001; F (2, 84)=8.267, p=.001, α=.05 respectively). We found a marginal interaction between participant group and age group on the RAPM (F (2, 112)=2.917, p=.058, α=.05) and a significant interaction on the Stroop test (F (2, 84)=4.998, p=.009, α=.05). Post-hoc analysis revealed that older participants performed significantly more poorly than younger participants (RAPM; p<.001; Stroop test: p=.001, α=.017, respectively). Middle-aged participants tended to perform more poorly than younger participants on the RAPM and Stroop tests (p=.038 and p=.021, α=.017, respectively). Age group significantly affected the performance of frontal patients on the RAPM and Stroop test (F (2, 112)=11.157, p<.001; F (2, 84)=11.915, p<.001, α=.017 respectively), but not in HC (F (2, 112)=1.490, p=.230; F (2, 84)=0.777, p=.463, α=.017 respectively). We performed post-hoc simple effects analyses and found that middle-aged and older frontal patients performed significantly more poorly than their HC counterparts (RAPM: p=.001 and p=.01 α=.017, respectively; Stroop test: p<.001 and p=.005 α=.017, respectively) and significantly more poorly than younger patients (RAPM: p=.016 and p<.001, α=.017 respectively; Stroop test: p=.001 and p<.001, α=.017, respectively; see Fig. 2).

Bottom Line: We found that only age consistently predicted the exacerbated executive impairment.Our results are in line with the notion that the frontal cortex plays a critical role in aging to counteract cognitive and neuronal decline.We suggest that the combined effect of aging and frontal lesions impairs the frontal cortical systems by causing its computational power to fall below the threshold needed to complete executive tasks successfully.

View Article: PubMed Central - PubMed

Affiliation: Department of Neuropsychology, National Hospital for Neurology and Neurosurgery, London, UK; Dipartimento di Psicologia, Università di Palermo, Italy. Electronic address: l.cipolotti@ucl.ac.uk.

No MeSH data available.


Related in: MedlinePlus