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Functions of Aurora kinase C in meiosis and cancer.

Quartuccio SM, Schindler K - Front Cell Dev Biol (2015)

Bottom Line: While Aurora kinase A (AURKA) and B (AURKB) are found in cells throughout the body, significant protein levels of Aurora kinase C (AURKC) are limited to cells that undergo meiosis (sperm and oocyte).Despite its discovery nearly 20 years ago, we know little about the function of AURKC compared to that of the other 2 Aurora kinases.Here, we consolidate and update what is known about AURKC signaling in meiotic cells to better understand why it has oncogenic potential.

View Article: PubMed Central - PubMed

Affiliation: Department of Genetics, Rutgers, The State University of New Jersey Piscataway, NJ, USA.

ABSTRACT
The mammalian genome encodes three Aurora kinase protein family members: A, B, and C. While Aurora kinase A (AURKA) and B (AURKB) are found in cells throughout the body, significant protein levels of Aurora kinase C (AURKC) are limited to cells that undergo meiosis (sperm and oocyte). Despite its discovery nearly 20 years ago, we know little about the function of AURKC compared to that of the other 2 Aurora kinases. This lack of understanding can be attributed to the high sequence homology between AURKB and AURKC preventing the use of standard approaches to understand non-overlapping and meiosis I (MI)-specific functions of the two kinases. Recent evidence has revealed distinct functions of AURKC in meiosis and may aid in our understanding of why chromosome segregation during MI often goes awry in oocytes. Many cancers aberrantly express AURKC, but because we do not fully understand AURKC function in its normal cellular context, it is difficult to predict the biological significance of this expression on the disease. Here, we consolidate and update what is known about AURKC signaling in meiotic cells to better understand why it has oncogenic potential.

No MeSH data available.


Related in: MedlinePlus

AURKC variants and Aurora kinase family members in mammals. Schematic of human AURKC variants (A) and Aurora kinase isoforms (B) with key domains and residues identified.
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Figure 1: AURKC variants and Aurora kinase family members in mammals. Schematic of human AURKC variants (A) and Aurora kinase isoforms (B) with key domains and residues identified.

Mentions: Alternative splicing results in three protein variants of AURKC (Bernard et al., 1998; Tseng et al., 1998; Yan et al., 2005b) (Figure 1A). Variants 2 and 3 lack amino acid residues in the N-terminus that do not appear to regulate localization (Fellmeth et al., 2015). While all variants are catalytically active, variant 1 is better at phosphorylating targets in oocytes suggesting the N-terminus positively regulates activity. Human oocytes contain all three variants while only one or two variants are measured in sperm (Fellmeth et al., 2015).


Functions of Aurora kinase C in meiosis and cancer.

Quartuccio SM, Schindler K - Front Cell Dev Biol (2015)

AURKC variants and Aurora kinase family members in mammals. Schematic of human AURKC variants (A) and Aurora kinase isoforms (B) with key domains and residues identified.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4542505&req=5

Figure 1: AURKC variants and Aurora kinase family members in mammals. Schematic of human AURKC variants (A) and Aurora kinase isoforms (B) with key domains and residues identified.
Mentions: Alternative splicing results in three protein variants of AURKC (Bernard et al., 1998; Tseng et al., 1998; Yan et al., 2005b) (Figure 1A). Variants 2 and 3 lack amino acid residues in the N-terminus that do not appear to regulate localization (Fellmeth et al., 2015). While all variants are catalytically active, variant 1 is better at phosphorylating targets in oocytes suggesting the N-terminus positively regulates activity. Human oocytes contain all three variants while only one or two variants are measured in sperm (Fellmeth et al., 2015).

Bottom Line: While Aurora kinase A (AURKA) and B (AURKB) are found in cells throughout the body, significant protein levels of Aurora kinase C (AURKC) are limited to cells that undergo meiosis (sperm and oocyte).Despite its discovery nearly 20 years ago, we know little about the function of AURKC compared to that of the other 2 Aurora kinases.Here, we consolidate and update what is known about AURKC signaling in meiotic cells to better understand why it has oncogenic potential.

View Article: PubMed Central - PubMed

Affiliation: Department of Genetics, Rutgers, The State University of New Jersey Piscataway, NJ, USA.

ABSTRACT
The mammalian genome encodes three Aurora kinase protein family members: A, B, and C. While Aurora kinase A (AURKA) and B (AURKB) are found in cells throughout the body, significant protein levels of Aurora kinase C (AURKC) are limited to cells that undergo meiosis (sperm and oocyte). Despite its discovery nearly 20 years ago, we know little about the function of AURKC compared to that of the other 2 Aurora kinases. This lack of understanding can be attributed to the high sequence homology between AURKB and AURKC preventing the use of standard approaches to understand non-overlapping and meiosis I (MI)-specific functions of the two kinases. Recent evidence has revealed distinct functions of AURKC in meiosis and may aid in our understanding of why chromosome segregation during MI often goes awry in oocytes. Many cancers aberrantly express AURKC, but because we do not fully understand AURKC function in its normal cellular context, it is difficult to predict the biological significance of this expression on the disease. Here, we consolidate and update what is known about AURKC signaling in meiotic cells to better understand why it has oncogenic potential.

No MeSH data available.


Related in: MedlinePlus