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Gray Matter Alterations in Post-Traumatic Stress Disorder, Obsessive-Compulsive Disorder, and Social Anxiety Disorder.

Cheng B, Huang X, Li S, Hu X, Luo Y, Wang X, Yang X, Qiu C, Yang Y, Zhang W, Bi F, Roberts N, Gong Q - Front Behav Neurosci (2015)

Bottom Line: Further analysis revealed that the PTSD group also showed reduced GMV in frontal lobe, temporal lobe, and cerebellum compared to the OCD group, and reduced GMV in frontal lobes bilaterally compared to SAD group.A significant negative correlation with anxiety symptoms is observed for GMV in left hypothalamus in three disorder groups.We have thus found evidence for brain structure differences that in future could provide biomarkers to potentially support classification of these disorders using MRI.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Huaxi MR Research Center, West China Hospital of Sichuan University , Chengdu , China.

ABSTRACT
Post-traumatic stress disorder (PTSD), obsessive-compulsive disorder (OCD), and social anxiety disorder (SAD) all bear the core symptom of anxiety and are separately classified in the new DSM-5 system. The aim of the present study is to obtain evidence for neuroanatomical difference for these disorders. We applied voxel-based morphometry (VBM) with Diffeomorphic Anatomical Registration Through Exponentiated Lie to compare gray matter volume (GMV) in magnetic resonance images obtained for 30 patients with PTSD, 29 patients with OCD, 20 patients with SAD, and 30 healthy controls. GMV across all four groups differed in left hypothalamus and left inferior parietal lobule and post hoc analyses revealed that this difference is primarily due to reduced GMV in the PTSD group relative to the other groups. Further analysis revealed that the PTSD group also showed reduced GMV in frontal lobe, temporal lobe, and cerebellum compared to the OCD group, and reduced GMV in frontal lobes bilaterally compared to SAD group. A significant negative correlation with anxiety symptoms is observed for GMV in left hypothalamus in three disorder groups. We have thus found evidence for brain structure differences that in future could provide biomarkers to potentially support classification of these disorders using MRI.

No MeSH data available.


Related in: MedlinePlus

Significant GMV differences were observed among PTSD, OCD, SAD and controls in left hypothalamus (A) and left IPL (B) shown projected onto the gray matter template built using DARTEL. Significant correlations were also observed between GMV in left hypothalamus and HAM-A (C) and HAM-D (D) scores. (Pcluster-level < 0.05 with a minimum cluster size of 70 voxels after FWE correction for whole-brain volume, age, and gender). Abbreviations: GMV, gray matter volume; DARTEL, Diffeomorphic Anatomical Registration Through Exponentiated Lie; HAM-A, Hamilton Rating Scale for Anxiety; HAM-D, Hamilton Rating Scale for Depression; IPL, inferior parietal lobule.
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Figure 1: Significant GMV differences were observed among PTSD, OCD, SAD and controls in left hypothalamus (A) and left IPL (B) shown projected onto the gray matter template built using DARTEL. Significant correlations were also observed between GMV in left hypothalamus and HAM-A (C) and HAM-D (D) scores. (Pcluster-level < 0.05 with a minimum cluster size of 70 voxels after FWE correction for whole-brain volume, age, and gender). Abbreviations: GMV, gray matter volume; DARTEL, Diffeomorphic Anatomical Registration Through Exponentiated Lie; HAM-A, Hamilton Rating Scale for Anxiety; HAM-D, Hamilton Rating Scale for Depression; IPL, inferior parietal lobule.

Mentions: GMV across the four groups differed significantly in left hypothalamus and left inferior parietal lobule (IPL; Figures 1A,B; Table 2). In addition, a post hoc analysis revealed that this difference was primarily due to differences between the PTSD group and the other groups (Figure 1). As shown in Figure 1, PTSD showed lower GMV in above-mentioned regions than all other three groups (p < 0.05).


Gray Matter Alterations in Post-Traumatic Stress Disorder, Obsessive-Compulsive Disorder, and Social Anxiety Disorder.

Cheng B, Huang X, Li S, Hu X, Luo Y, Wang X, Yang X, Qiu C, Yang Y, Zhang W, Bi F, Roberts N, Gong Q - Front Behav Neurosci (2015)

Significant GMV differences were observed among PTSD, OCD, SAD and controls in left hypothalamus (A) and left IPL (B) shown projected onto the gray matter template built using DARTEL. Significant correlations were also observed between GMV in left hypothalamus and HAM-A (C) and HAM-D (D) scores. (Pcluster-level < 0.05 with a minimum cluster size of 70 voxels after FWE correction for whole-brain volume, age, and gender). Abbreviations: GMV, gray matter volume; DARTEL, Diffeomorphic Anatomical Registration Through Exponentiated Lie; HAM-A, Hamilton Rating Scale for Anxiety; HAM-D, Hamilton Rating Scale for Depression; IPL, inferior parietal lobule.
© Copyright Policy
Related In: Results  -  Collection

License
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getmorefigures.php?uid=PMC4542504&req=5

Figure 1: Significant GMV differences were observed among PTSD, OCD, SAD and controls in left hypothalamus (A) and left IPL (B) shown projected onto the gray matter template built using DARTEL. Significant correlations were also observed between GMV in left hypothalamus and HAM-A (C) and HAM-D (D) scores. (Pcluster-level < 0.05 with a minimum cluster size of 70 voxels after FWE correction for whole-brain volume, age, and gender). Abbreviations: GMV, gray matter volume; DARTEL, Diffeomorphic Anatomical Registration Through Exponentiated Lie; HAM-A, Hamilton Rating Scale for Anxiety; HAM-D, Hamilton Rating Scale for Depression; IPL, inferior parietal lobule.
Mentions: GMV across the four groups differed significantly in left hypothalamus and left inferior parietal lobule (IPL; Figures 1A,B; Table 2). In addition, a post hoc analysis revealed that this difference was primarily due to differences between the PTSD group and the other groups (Figure 1). As shown in Figure 1, PTSD showed lower GMV in above-mentioned regions than all other three groups (p < 0.05).

Bottom Line: Further analysis revealed that the PTSD group also showed reduced GMV in frontal lobe, temporal lobe, and cerebellum compared to the OCD group, and reduced GMV in frontal lobes bilaterally compared to SAD group.A significant negative correlation with anxiety symptoms is observed for GMV in left hypothalamus in three disorder groups.We have thus found evidence for brain structure differences that in future could provide biomarkers to potentially support classification of these disorders using MRI.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Huaxi MR Research Center, West China Hospital of Sichuan University , Chengdu , China.

ABSTRACT
Post-traumatic stress disorder (PTSD), obsessive-compulsive disorder (OCD), and social anxiety disorder (SAD) all bear the core symptom of anxiety and are separately classified in the new DSM-5 system. The aim of the present study is to obtain evidence for neuroanatomical difference for these disorders. We applied voxel-based morphometry (VBM) with Diffeomorphic Anatomical Registration Through Exponentiated Lie to compare gray matter volume (GMV) in magnetic resonance images obtained for 30 patients with PTSD, 29 patients with OCD, 20 patients with SAD, and 30 healthy controls. GMV across all four groups differed in left hypothalamus and left inferior parietal lobule and post hoc analyses revealed that this difference is primarily due to reduced GMV in the PTSD group relative to the other groups. Further analysis revealed that the PTSD group also showed reduced GMV in frontal lobe, temporal lobe, and cerebellum compared to the OCD group, and reduced GMV in frontal lobes bilaterally compared to SAD group. A significant negative correlation with anxiety symptoms is observed for GMV in left hypothalamus in three disorder groups. We have thus found evidence for brain structure differences that in future could provide biomarkers to potentially support classification of these disorders using MRI.

No MeSH data available.


Related in: MedlinePlus