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Effect of ethnicity and socioeconomic variation to the gut microbiota composition among pre-adolescent in Malaysia.

Chong CW, Ahmad AF, Lim YA, Teh CS, Yap IK, Lee SC, Chin YT, Loke P, Chua KH - Sci Rep (2015)

Bottom Line: Here, we compared the gut bacterial richness and composition of pre-adolescence in Northern Malaysia.Our results suggested a strong ethnicity and socioeconomic-linked bacterial diversity.In addition, predicted functional metagenome profiling suggested an over-representation of pathways pertinent to bacterial colonisation and chemotaxis in the former while the latter exhibited enriched gene pathways related to sugar metabolism.

View Article: PubMed Central - PubMed

Affiliation: Department of Life Sciences, School of Pharmacy, International Medical University, 57000 Kuala Lumpur, Malaysia.

ABSTRACT
Gut microbiota plays an important role in mammalian host metabolism and physiological functions. The functions are particularly important in young children where rapid mental and physical developments are taking place. Nevertheless, little is known about the gut microbiome and the factors that contribute to microbial variation in the gut of South East Asian children. Here, we compared the gut bacterial richness and composition of pre-adolescence in Northern Malaysia. Our subjects covered three distinct ethnic groups with relatively narrow range of socioeconomic discrepancy. These included the Malays (n = 24), Chinese (n = 17) and the Orang Asli (indigenous) (n = 20). Our results suggested a strong ethnicity and socioeconomic-linked bacterial diversity. Highest bacterial diversity was detected from the economically deprived indigenous children while the lowest diversity was recorded from the relatively wealthy Chinese children. In addition, predicted functional metagenome profiling suggested an over-representation of pathways pertinent to bacterial colonisation and chemotaxis in the former while the latter exhibited enriched gene pathways related to sugar metabolism.

No MeSH data available.


Pairwise comparison of the predicted functional profiles.Note: Only statistical significant features (P < 0.05) were included in the figure.
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f4: Pairwise comparison of the predicted functional profiles.Note: Only statistical significant features (P < 0.05) were included in the figure.

Mentions: The faecal bacterial composition was used to estimate the functional difference in the children across three ethnic groups. As expected, gut microbiota in Orang Asli children was predicted to perform more unique functions in comparison to Chinese and Malay children (Fig. S3). From a total of 328 KEGG features, 13 were significantly different between Chinese and Malays, 42 between Malays and Orang Asli, and 124 between Chinese and Orang Asli (Fig. 4). Within the selected KEGG functions, we found 32 features shared by Malays and Chinese which were distinct from the Orang Asli. These included pathways related to bacterial colonisation such as bacterial chemotaxis, flagella assembly, and bacterial motility proteins which were also enriched in the Orang Asli. Conversely, elevated protein and fat related metabolism pathways including bile acid biosynthesis, and amino acid and protein metabolism were detected in both Malays and Chinese. Finally, the functional profiles also suggested that the Chinese might have a higher capability in sugar anabolism and catabolism as several features related to the function was significantly higher in Chinese in comparison to the others.


Effect of ethnicity and socioeconomic variation to the gut microbiota composition among pre-adolescent in Malaysia.

Chong CW, Ahmad AF, Lim YA, Teh CS, Yap IK, Lee SC, Chin YT, Loke P, Chua KH - Sci Rep (2015)

Pairwise comparison of the predicted functional profiles.Note: Only statistical significant features (P < 0.05) were included in the figure.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4542465&req=5

f4: Pairwise comparison of the predicted functional profiles.Note: Only statistical significant features (P < 0.05) were included in the figure.
Mentions: The faecal bacterial composition was used to estimate the functional difference in the children across three ethnic groups. As expected, gut microbiota in Orang Asli children was predicted to perform more unique functions in comparison to Chinese and Malay children (Fig. S3). From a total of 328 KEGG features, 13 were significantly different between Chinese and Malays, 42 between Malays and Orang Asli, and 124 between Chinese and Orang Asli (Fig. 4). Within the selected KEGG functions, we found 32 features shared by Malays and Chinese which were distinct from the Orang Asli. These included pathways related to bacterial colonisation such as bacterial chemotaxis, flagella assembly, and bacterial motility proteins which were also enriched in the Orang Asli. Conversely, elevated protein and fat related metabolism pathways including bile acid biosynthesis, and amino acid and protein metabolism were detected in both Malays and Chinese. Finally, the functional profiles also suggested that the Chinese might have a higher capability in sugar anabolism and catabolism as several features related to the function was significantly higher in Chinese in comparison to the others.

Bottom Line: Here, we compared the gut bacterial richness and composition of pre-adolescence in Northern Malaysia.Our results suggested a strong ethnicity and socioeconomic-linked bacterial diversity.In addition, predicted functional metagenome profiling suggested an over-representation of pathways pertinent to bacterial colonisation and chemotaxis in the former while the latter exhibited enriched gene pathways related to sugar metabolism.

View Article: PubMed Central - PubMed

Affiliation: Department of Life Sciences, School of Pharmacy, International Medical University, 57000 Kuala Lumpur, Malaysia.

ABSTRACT
Gut microbiota plays an important role in mammalian host metabolism and physiological functions. The functions are particularly important in young children where rapid mental and physical developments are taking place. Nevertheless, little is known about the gut microbiome and the factors that contribute to microbial variation in the gut of South East Asian children. Here, we compared the gut bacterial richness and composition of pre-adolescence in Northern Malaysia. Our subjects covered three distinct ethnic groups with relatively narrow range of socioeconomic discrepancy. These included the Malays (n = 24), Chinese (n = 17) and the Orang Asli (indigenous) (n = 20). Our results suggested a strong ethnicity and socioeconomic-linked bacterial diversity. Highest bacterial diversity was detected from the economically deprived indigenous children while the lowest diversity was recorded from the relatively wealthy Chinese children. In addition, predicted functional metagenome profiling suggested an over-representation of pathways pertinent to bacterial colonisation and chemotaxis in the former while the latter exhibited enriched gene pathways related to sugar metabolism.

No MeSH data available.