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Design and Optimization of SiON Ring Resonator-Based Biosensors for Aflatoxin M1 Detection.

Guider R, Gandolfi D, Chalyan T, Pasquardini L, Samusenko A, Pucker G, Pederzolli C, Pavesi L - Sensors (Basel) (2015)

Bottom Line: Sensitivities and limit of detection (LOD) were also measured using glucose-water solutions and compared with expected results from simulations.We were able to detect the binding of aflatoxin for concentrations as low as 12.5 nm.The results open up the path for designing cost-effective biosensors for a fast and reliable sensitive analysis of AFM1 in milk.

View Article: PubMed Central - PubMed

Affiliation: Nanoscience Laboratory, Department of Physics, University of Trento, Via Sommarive 14, Povo (TN) 38123, Italy. romain.guider@unitn.it.

ABSTRACT
In this article, we designed and studied silicon oxynitride (SiON) microring-based photonic structures for biosensing applications. We designed waveguides, directional couplers, and racetrack resonators in order to measure refractive index changes smaller than 10-6 refractive index units (RIU). We tested various samples with different SiON refractive indexes as well as the waveguide dimensions for selecting the sensor with the best performance. Propagation losses and bending losses have been measured on test structures, along with a complete characterization of the resonator's performances. Sensitivities and limit of detection (LOD) were also measured using glucose-water solutions and compared with expected results from simulations. Finally, we functionalized the resonator and performed sensing experiments with Aflatoxin M1 (AFM1). We were able to detect the binding of aflatoxin for concentrations as low as 12.5 nm. The results open up the path for designing cost-effective biosensors for a fast and reliable sensitive analysis of AFM1 in milk.

No MeSH data available.


Sketch and microscope picture of the ring resonators sample. In the microscope image, we can clearly observe the etching windows around the resonators that allow the functionalization of the sensors.
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sensors-15-17300-f002: Sketch and microscope picture of the ring resonators sample. In the microscope image, we can clearly observe the etching windows around the resonators that allow the functionalization of the sensors.

Mentions: According to our calculations, we designed several racetrack structures with coupling lengths varying between 0 and 64 µm, with a gap of 600 nm. Such a range of values should allow us to identify the optimal coupling length depending on the quality factor of the resonators. A sketch and microscope image of the sample is presented in Figure 2.


Design and Optimization of SiON Ring Resonator-Based Biosensors for Aflatoxin M1 Detection.

Guider R, Gandolfi D, Chalyan T, Pasquardini L, Samusenko A, Pucker G, Pederzolli C, Pavesi L - Sensors (Basel) (2015)

Sketch and microscope picture of the ring resonators sample. In the microscope image, we can clearly observe the etching windows around the resonators that allow the functionalization of the sensors.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4541935&req=5

sensors-15-17300-f002: Sketch and microscope picture of the ring resonators sample. In the microscope image, we can clearly observe the etching windows around the resonators that allow the functionalization of the sensors.
Mentions: According to our calculations, we designed several racetrack structures with coupling lengths varying between 0 and 64 µm, with a gap of 600 nm. Such a range of values should allow us to identify the optimal coupling length depending on the quality factor of the resonators. A sketch and microscope image of the sample is presented in Figure 2.

Bottom Line: Sensitivities and limit of detection (LOD) were also measured using glucose-water solutions and compared with expected results from simulations.We were able to detect the binding of aflatoxin for concentrations as low as 12.5 nm.The results open up the path for designing cost-effective biosensors for a fast and reliable sensitive analysis of AFM1 in milk.

View Article: PubMed Central - PubMed

Affiliation: Nanoscience Laboratory, Department of Physics, University of Trento, Via Sommarive 14, Povo (TN) 38123, Italy. romain.guider@unitn.it.

ABSTRACT
In this article, we designed and studied silicon oxynitride (SiON) microring-based photonic structures for biosensing applications. We designed waveguides, directional couplers, and racetrack resonators in order to measure refractive index changes smaller than 10-6 refractive index units (RIU). We tested various samples with different SiON refractive indexes as well as the waveguide dimensions for selecting the sensor with the best performance. Propagation losses and bending losses have been measured on test structures, along with a complete characterization of the resonator's performances. Sensitivities and limit of detection (LOD) were also measured using glucose-water solutions and compared with expected results from simulations. Finally, we functionalized the resonator and performed sensing experiments with Aflatoxin M1 (AFM1). We were able to detect the binding of aflatoxin for concentrations as low as 12.5 nm. The results open up the path for designing cost-effective biosensors for a fast and reliable sensitive analysis of AFM1 in milk.

No MeSH data available.