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Design and Optimization of SiON Ring Resonator-Based Biosensors for Aflatoxin M1 Detection.

Guider R, Gandolfi D, Chalyan T, Pasquardini L, Samusenko A, Pucker G, Pederzolli C, Pavesi L - Sensors (Basel) (2015)

Bottom Line: Sensitivities and limit of detection (LOD) were also measured using glucose-water solutions and compared with expected results from simulations.We were able to detect the binding of aflatoxin for concentrations as low as 12.5 nm.The results open up the path for designing cost-effective biosensors for a fast and reliable sensitive analysis of AFM1 in milk.

View Article: PubMed Central - PubMed

Affiliation: Nanoscience Laboratory, Department of Physics, University of Trento, Via Sommarive 14, Povo (TN) 38123, Italy. romain.guider@unitn.it.

ABSTRACT
In this article, we designed and studied silicon oxynitride (SiON) microring-based photonic structures for biosensing applications. We designed waveguides, directional couplers, and racetrack resonators in order to measure refractive index changes smaller than 10-6 refractive index units (RIU). We tested various samples with different SiON refractive indexes as well as the waveguide dimensions for selecting the sensor with the best performance. Propagation losses and bending losses have been measured on test structures, along with a complete characterization of the resonator's performances. Sensitivities and limit of detection (LOD) were also measured using glucose-water solutions and compared with expected results from simulations. Finally, we functionalized the resonator and performed sensing experiments with Aflatoxin M1 (AFM1). We were able to detect the binding of aflatoxin for concentrations as low as 12.5 nm. The results open up the path for designing cost-effective biosensors for a fast and reliable sensitive analysis of AFM1 in milk.

No MeSH data available.


(Left) Quality factors in function of the waveguide thickness simulated for nSiON = 1.66 and 1.8 for both transverse electric (TE) and transverse magnetic (TM) polarizations; (Right) Bulk sensitivity in function of the waveguide thickness simulated for nSiON = 1.66 and 1.8 for both TE and TM polarizations.
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sensors-15-17300-f001: (Left) Quality factors in function of the waveguide thickness simulated for nSiON = 1.66 and 1.8 for both transverse electric (TE) and transverse magnetic (TM) polarizations; (Right) Bulk sensitivity in function of the waveguide thickness simulated for nSiON = 1.66 and 1.8 for both TE and TM polarizations.

Mentions: While reducing the thickness, the mode confinement is reduced and the light-analyte interaction increases, thus enhancing the sensitivity. As represented in Figure 1, after a critical level, the mode starts to leak in the substrate, reducing the sensitivity in the upper cladding.


Design and Optimization of SiON Ring Resonator-Based Biosensors for Aflatoxin M1 Detection.

Guider R, Gandolfi D, Chalyan T, Pasquardini L, Samusenko A, Pucker G, Pederzolli C, Pavesi L - Sensors (Basel) (2015)

(Left) Quality factors in function of the waveguide thickness simulated for nSiON = 1.66 and 1.8 for both transverse electric (TE) and transverse magnetic (TM) polarizations; (Right) Bulk sensitivity in function of the waveguide thickness simulated for nSiON = 1.66 and 1.8 for both TE and TM polarizations.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4541935&req=5

sensors-15-17300-f001: (Left) Quality factors in function of the waveguide thickness simulated for nSiON = 1.66 and 1.8 for both transverse electric (TE) and transverse magnetic (TM) polarizations; (Right) Bulk sensitivity in function of the waveguide thickness simulated for nSiON = 1.66 and 1.8 for both TE and TM polarizations.
Mentions: While reducing the thickness, the mode confinement is reduced and the light-analyte interaction increases, thus enhancing the sensitivity. As represented in Figure 1, after a critical level, the mode starts to leak in the substrate, reducing the sensitivity in the upper cladding.

Bottom Line: Sensitivities and limit of detection (LOD) were also measured using glucose-water solutions and compared with expected results from simulations.We were able to detect the binding of aflatoxin for concentrations as low as 12.5 nm.The results open up the path for designing cost-effective biosensors for a fast and reliable sensitive analysis of AFM1 in milk.

View Article: PubMed Central - PubMed

Affiliation: Nanoscience Laboratory, Department of Physics, University of Trento, Via Sommarive 14, Povo (TN) 38123, Italy. romain.guider@unitn.it.

ABSTRACT
In this article, we designed and studied silicon oxynitride (SiON) microring-based photonic structures for biosensing applications. We designed waveguides, directional couplers, and racetrack resonators in order to measure refractive index changes smaller than 10-6 refractive index units (RIU). We tested various samples with different SiON refractive indexes as well as the waveguide dimensions for selecting the sensor with the best performance. Propagation losses and bending losses have been measured on test structures, along with a complete characterization of the resonator's performances. Sensitivities and limit of detection (LOD) were also measured using glucose-water solutions and compared with expected results from simulations. Finally, we functionalized the resonator and performed sensing experiments with Aflatoxin M1 (AFM1). We were able to detect the binding of aflatoxin for concentrations as low as 12.5 nm. The results open up the path for designing cost-effective biosensors for a fast and reliable sensitive analysis of AFM1 in milk.

No MeSH data available.