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Effect of remote ischemic postconditioning in inflammatory changes of the lung parenchyma of rats submitted to ischemia and reperfusion.

Dorsa RC, Pontes JC, Antoniolli AC, Silva GV, Benfatti RA, Santos CH, Pontes ER, Goldiano JA - Rev Bras Cir Cardiovasc (2015 Jul-Sep)

Bottom Line: To assess the effects of postconditioning remote in ischemia-reperfusion injury in rat lungs.Statistical analysis of the mean rating of the degree of tissue injury.GA (3.6), GB (1.3) and CG (1.0). (GA GB X P<0.05).

View Article: PubMed Central - PubMed

Affiliation: Federal University of Mato Grosso do Sul, Campo Grande, MS, BR.

ABSTRACT

Objective: To assess the effects of postconditioning remote in ischemia-reperfusion injury in rat lungs.

Methods: Wistar rats (n=24) divided into 3 groups: GA (I/R) n=8, GB (R-Po) n=8, CG (control) n=8, underwent ischemia for 30 minutes artery occlusion abdominal aorta, followed by reperfusion for 60 minutes. Resected lungs and performed histological analysis and classification of morphological findings in accordance with the degree of tissue injury. Statistical analysis of the mean rating of the degree of tissue injury.

Results: GA (3.6), GB (1.3) and CG (1.0). (GA GB X P<0.05).

Conclusion: The remote postconditioning was able to minimize the inflammatory lesion of the lung parenchyma of rats undergoing ischemia and reperfusion process.

No MeSH data available.


Related in: MedlinePlus

Mean and standard deviation scores of the focal edema at histological examinationin groups: A (ischemia and reperfusion), B (remote postconditioning) and C(control).Note: Kruskal Wallis followed by Student-Newman – Keuls test. Equal lowercaseletters indicate statistically significant difference. Different lowercase lettersindicate statistically significant difference. P-value=<0.001; A x B:P-value=0.002; A x C: P-value=<0.001; B x C: P-value=0.572.
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f05: Mean and standard deviation scores of the focal edema at histological examinationin groups: A (ischemia and reperfusion), B (remote postconditioning) and C(control).Note: Kruskal Wallis followed by Student-Newman – Keuls test. Equal lowercaseletters indicate statistically significant difference. Different lowercase lettersindicate statistically significant difference. P-value=<0.001; A x B:P-value=0.002; A x C: P-value=<0.001; B x C: P-value=0.572.

Mentions: The mean degree of histological classification of Greca et al.[8] of groups I/R and R-PosC weresubjected to statistical analysis by Kruskal Wallis test where it was found aP value of 0.002 showing that the difference between groups wasstatistically significant (Figure 5).


Effect of remote ischemic postconditioning in inflammatory changes of the lung parenchyma of rats submitted to ischemia and reperfusion.

Dorsa RC, Pontes JC, Antoniolli AC, Silva GV, Benfatti RA, Santos CH, Pontes ER, Goldiano JA - Rev Bras Cir Cardiovasc (2015 Jul-Sep)

Mean and standard deviation scores of the focal edema at histological examinationin groups: A (ischemia and reperfusion), B (remote postconditioning) and C(control).Note: Kruskal Wallis followed by Student-Newman – Keuls test. Equal lowercaseletters indicate statistically significant difference. Different lowercase lettersindicate statistically significant difference. P-value=<0.001; A x B:P-value=0.002; A x C: P-value=<0.001; B x C: P-value=0.572.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4541782&req=5

f05: Mean and standard deviation scores of the focal edema at histological examinationin groups: A (ischemia and reperfusion), B (remote postconditioning) and C(control).Note: Kruskal Wallis followed by Student-Newman – Keuls test. Equal lowercaseletters indicate statistically significant difference. Different lowercase lettersindicate statistically significant difference. P-value=<0.001; A x B:P-value=0.002; A x C: P-value=<0.001; B x C: P-value=0.572.
Mentions: The mean degree of histological classification of Greca et al.[8] of groups I/R and R-PosC weresubjected to statistical analysis by Kruskal Wallis test where it was found aP value of 0.002 showing that the difference between groups wasstatistically significant (Figure 5).

Bottom Line: To assess the effects of postconditioning remote in ischemia-reperfusion injury in rat lungs.Statistical analysis of the mean rating of the degree of tissue injury.GA (3.6), GB (1.3) and CG (1.0). (GA GB X P<0.05).

View Article: PubMed Central - PubMed

Affiliation: Federal University of Mato Grosso do Sul, Campo Grande, MS, BR.

ABSTRACT

Objective: To assess the effects of postconditioning remote in ischemia-reperfusion injury in rat lungs.

Methods: Wistar rats (n=24) divided into 3 groups: GA (I/R) n=8, GB (R-Po) n=8, CG (control) n=8, underwent ischemia for 30 minutes artery occlusion abdominal aorta, followed by reperfusion for 60 minutes. Resected lungs and performed histological analysis and classification of morphological findings in accordance with the degree of tissue injury. Statistical analysis of the mean rating of the degree of tissue injury.

Results: GA (3.6), GB (1.3) and CG (1.0). (GA GB X P<0.05).

Conclusion: The remote postconditioning was able to minimize the inflammatory lesion of the lung parenchyma of rats undergoing ischemia and reperfusion process.

No MeSH data available.


Related in: MedlinePlus