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Effect of remote ischemic postconditioning in inflammatory changes of the lung parenchyma of rats submitted to ischemia and reperfusion.

Dorsa RC, Pontes JC, Antoniolli AC, Silva GV, Benfatti RA, Santos CH, Pontes ER, Goldiano JA - Rev Bras Cir Cardiovasc (2015 Jul-Sep)

Bottom Line: To assess the effects of postconditioning remote in ischemia-reperfusion injury in rat lungs.Statistical analysis of the mean rating of the degree of tissue injury.GA (3.6), GB (1.3) and CG (1.0). (GA GB X P<0.05).

View Article: PubMed Central - PubMed

Affiliation: Federal University of Mato Grosso do Sul, Campo Grande, MS, BR.

ABSTRACT

Objective: To assess the effects of postconditioning remote in ischemia-reperfusion injury in rat lungs.

Methods: Wistar rats (n=24) divided into 3 groups: GA (I/R) n=8, GB (R-Po) n=8, CG (control) n=8, underwent ischemia for 30 minutes artery occlusion abdominal aorta, followed by reperfusion for 60 minutes. Resected lungs and performed histological analysis and classification of morphological findings in accordance with the degree of tissue injury. Statistical analysis of the mean rating of the degree of tissue injury.

Results: GA (3.6), GB (1.3) and CG (1.0). (GA GB X P<0.05).

Conclusion: The remote postconditioning was able to minimize the inflammatory lesion of the lung parenchyma of rats undergoing ischemia and reperfusion process.

No MeSH data available.


Related in: MedlinePlus

Photograph of histological changes of the lung parenchyma at regular, mild,moderate and intense degrees according Greca et al.[8] classification. (40Xoptical microscopy - hematoxylin-eosin staining).
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f04: Photograph of histological changes of the lung parenchyma at regular, mild,moderate and intense degrees according Greca et al.[8] classification. (40Xoptical microscopy - hematoxylin-eosin staining).

Mentions: For histological analysis of the lungs we used the hematoxylin-eosin and the reading ofthe slides was performed by the same pathologist, who was blinded to the study, whichconsidered for description of morphological findings, the classification according tothe degree of tissue injury described by Greca et al.[8] (Table 1and Figure 4). We selected three random locationson each lung for analysis: apex, middle third and base, being observed five fields ofeach slides, resulting in the predominant lesion.


Effect of remote ischemic postconditioning in inflammatory changes of the lung parenchyma of rats submitted to ischemia and reperfusion.

Dorsa RC, Pontes JC, Antoniolli AC, Silva GV, Benfatti RA, Santos CH, Pontes ER, Goldiano JA - Rev Bras Cir Cardiovasc (2015 Jul-Sep)

Photograph of histological changes of the lung parenchyma at regular, mild,moderate and intense degrees according Greca et al.[8] classification. (40Xoptical microscopy - hematoxylin-eosin staining).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4541782&req=5

f04: Photograph of histological changes of the lung parenchyma at regular, mild,moderate and intense degrees according Greca et al.[8] classification. (40Xoptical microscopy - hematoxylin-eosin staining).
Mentions: For histological analysis of the lungs we used the hematoxylin-eosin and the reading ofthe slides was performed by the same pathologist, who was blinded to the study, whichconsidered for description of morphological findings, the classification according tothe degree of tissue injury described by Greca et al.[8] (Table 1and Figure 4). We selected three random locationson each lung for analysis: apex, middle third and base, being observed five fields ofeach slides, resulting in the predominant lesion.

Bottom Line: To assess the effects of postconditioning remote in ischemia-reperfusion injury in rat lungs.Statistical analysis of the mean rating of the degree of tissue injury.GA (3.6), GB (1.3) and CG (1.0). (GA GB X P<0.05).

View Article: PubMed Central - PubMed

Affiliation: Federal University of Mato Grosso do Sul, Campo Grande, MS, BR.

ABSTRACT

Objective: To assess the effects of postconditioning remote in ischemia-reperfusion injury in rat lungs.

Methods: Wistar rats (n=24) divided into 3 groups: GA (I/R) n=8, GB (R-Po) n=8, CG (control) n=8, underwent ischemia for 30 minutes artery occlusion abdominal aorta, followed by reperfusion for 60 minutes. Resected lungs and performed histological analysis and classification of morphological findings in accordance with the degree of tissue injury. Statistical analysis of the mean rating of the degree of tissue injury.

Results: GA (3.6), GB (1.3) and CG (1.0). (GA GB X P<0.05).

Conclusion: The remote postconditioning was able to minimize the inflammatory lesion of the lung parenchyma of rats undergoing ischemia and reperfusion process.

No MeSH data available.


Related in: MedlinePlus