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Effect of remote ischemic postconditioning in inflammatory changes of the lung parenchyma of rats submitted to ischemia and reperfusion.

Dorsa RC, Pontes JC, Antoniolli AC, Silva GV, Benfatti RA, Santos CH, Pontes ER, Goldiano JA - Rev Bras Cir Cardiovasc (2015 Jul-Sep)

Bottom Line: To assess the effects of postconditioning remote in ischemia-reperfusion injury in rat lungs.Statistical analysis of the mean rating of the degree of tissue injury.GA (3.6), GB (1.3) and CG (1.0). (GA GB X P<0.05).

View Article: PubMed Central - PubMed

Affiliation: Federal University of Mato Grosso do Sul, Campo Grande, MS, BR.

ABSTRACT

Objective: To assess the effects of postconditioning remote in ischemia-reperfusion injury in rat lungs.

Methods: Wistar rats (n=24) divided into 3 groups: GA (I/R) n=8, GB (R-Po) n=8, CG (control) n=8, underwent ischemia for 30 minutes artery occlusion abdominal aorta, followed by reperfusion for 60 minutes. Resected lungs and performed histological analysis and classification of morphological findings in accordance with the degree of tissue injury. Statistical analysis of the mean rating of the degree of tissue injury.

Results: GA (3.6), GB (1.3) and CG (1.0). (GA GB X P<0.05).

Conclusion: The remote postconditioning was able to minimize the inflammatory lesion of the lung parenchyma of rats undergoing ischemia and reperfusion process.

No MeSH data available.


Related in: MedlinePlus

Clamp in the abdominal aorta.
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f02: Clamp in the abdominal aorta.

Mentions: In group A, the abdominal aortic artery was occluded with atraumatic vascular clampwhich remained for thirty minutes (ischemic phase) (Figure 2). In all three groups the wound was covered with gauze moistenedwith saline solution at 0.9%. After the stage of ischemia, vascular clamp was removed,beginning the reperfusion phase, lasting 60 minutes. In all three groups, the surgicalwound was closed during the reperfusion sutured by simple running suture using 3-0mononylon.


Effect of remote ischemic postconditioning in inflammatory changes of the lung parenchyma of rats submitted to ischemia and reperfusion.

Dorsa RC, Pontes JC, Antoniolli AC, Silva GV, Benfatti RA, Santos CH, Pontes ER, Goldiano JA - Rev Bras Cir Cardiovasc (2015 Jul-Sep)

Clamp in the abdominal aorta.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4541782&req=5

f02: Clamp in the abdominal aorta.
Mentions: In group A, the abdominal aortic artery was occluded with atraumatic vascular clampwhich remained for thirty minutes (ischemic phase) (Figure 2). In all three groups the wound was covered with gauze moistenedwith saline solution at 0.9%. After the stage of ischemia, vascular clamp was removed,beginning the reperfusion phase, lasting 60 minutes. In all three groups, the surgicalwound was closed during the reperfusion sutured by simple running suture using 3-0mononylon.

Bottom Line: To assess the effects of postconditioning remote in ischemia-reperfusion injury in rat lungs.Statistical analysis of the mean rating of the degree of tissue injury.GA (3.6), GB (1.3) and CG (1.0). (GA GB X P<0.05).

View Article: PubMed Central - PubMed

Affiliation: Federal University of Mato Grosso do Sul, Campo Grande, MS, BR.

ABSTRACT

Objective: To assess the effects of postconditioning remote in ischemia-reperfusion injury in rat lungs.

Methods: Wistar rats (n=24) divided into 3 groups: GA (I/R) n=8, GB (R-Po) n=8, CG (control) n=8, underwent ischemia for 30 minutes artery occlusion abdominal aorta, followed by reperfusion for 60 minutes. Resected lungs and performed histological analysis and classification of morphological findings in accordance with the degree of tissue injury. Statistical analysis of the mean rating of the degree of tissue injury.

Results: GA (3.6), GB (1.3) and CG (1.0). (GA GB X P<0.05).

Conclusion: The remote postconditioning was able to minimize the inflammatory lesion of the lung parenchyma of rats undergoing ischemia and reperfusion process.

No MeSH data available.


Related in: MedlinePlus