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PET/CT imaging in lung cancer: indications and findings.

Hochhegger B, Alves GR, Irion KL, Fritscher CC, Fritscher LG, Concatto NH, Marchiori E - J Bras Pneumol (2015 May-Jun)

Bottom Line: In addition, the accuracy of PET/CT has been shown to be greater than is that of conventional modalities in some scenarios, making PET/CT a valuable noninvasive method for the investigation of lung cancer.However, the interpretation of PET/CT findings presents numerous pitfalls and potential confounders.Therefore, it is imperative for pulmonologists and radiologists to familiarize themselves with the most relevant indications for and limitations of PET/CT, seeking to protect their patients from unnecessary radiation exposure and inappropriate treatment.

View Article: PubMed Central - PubMed

Affiliation: Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

ABSTRACT
The use of PET/CT imaging in the work-up and management of patients with lung cancer has greatly increased in recent decades. The ability to combine functional and anatomical information has equipped PET/CT to look into various aspects of lung cancer, allowing more precise disease staging and providing useful data during the characterization of indeterminate pulmonary nodules. In addition, the accuracy of PET/CT has been shown to be greater than is that of conventional modalities in some scenarios, making PET/CT a valuable noninvasive method for the investigation of lung cancer. However, the interpretation of PET/CT findings presents numerous pitfalls and potential confounders. Therefore, it is imperative for pulmonologists and radiologists to familiarize themselves with the most relevant indications for and limitations of PET/CT, seeking to protect their patients from unnecessary radiation exposure and inappropriate treatment. This review article aimed to summarize the basic principles, indications, cancer staging considerations, and future applications related to the use of PET/CT in lung cancer.

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Related in: MedlinePlus

PET/TC de paciente do sexo masculino, de 60 anos de idade, com diagnóstico de câncer de pulmão de células não pequenas e recebendo radioterapia. Apesar da detecção de uma grande massa no lobo superior direito na TC de tórax (A), a diferenciação entre o tumor e as estruturas normais circundantes não teria sido viável sem o auxílio da PET/TC (B).
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f09: PET/TC de paciente do sexo masculino, de 60 anos de idade, com diagnóstico de câncer de pulmão de células não pequenas e recebendo radioterapia. Apesar da detecção de uma grande massa no lobo superior direito na TC de tórax (A), a diferenciação entre o tumor e as estruturas normais circundantes não teria sido viável sem o auxílio da PET/TC (B).

Mentions: A maior acurácia diagnóstica proporcionada pela PET/TC tem tido um grande impacto no tratamento de pacientes com câncer de pulmão submetidos à radioterapia. Essa acurácia melhorou a radioterapia para câncer de pulmão principalmente porque permite a definição precisa dos limites do(s) tumor(es), evitando assim a definição errônea do alvo (mistargeting) e a irradiação desnecessária de estruturas adjacentes (Figura 4). Por exemplo, estudos recentes demonstraram que o uso da PET/TC no planejamento da radioterapia foi capaz de reduzir de forma consistente as doses de radiação para lesões esofágicas e pulmonares.(19,20) Além disso, a maior sensibilidade da FDG-PET (em comparação à TC) na detecção de linfonodos mediastinais anormais permitiu que a PET/TC fosse usada na delineação de volumes alvos utilizando contorno anatômico biológico, com resultados ainda melhores.(3)


PET/CT imaging in lung cancer: indications and findings.

Hochhegger B, Alves GR, Irion KL, Fritscher CC, Fritscher LG, Concatto NH, Marchiori E - J Bras Pneumol (2015 May-Jun)

PET/TC de paciente do sexo masculino, de 60 anos de idade, com diagnóstico de câncer de pulmão de células não pequenas e recebendo radioterapia. Apesar da detecção de uma grande massa no lobo superior direito na TC de tórax (A), a diferenciação entre o tumor e as estruturas normais circundantes não teria sido viável sem o auxílio da PET/TC (B).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4541763&req=5

f09: PET/TC de paciente do sexo masculino, de 60 anos de idade, com diagnóstico de câncer de pulmão de células não pequenas e recebendo radioterapia. Apesar da detecção de uma grande massa no lobo superior direito na TC de tórax (A), a diferenciação entre o tumor e as estruturas normais circundantes não teria sido viável sem o auxílio da PET/TC (B).
Mentions: A maior acurácia diagnóstica proporcionada pela PET/TC tem tido um grande impacto no tratamento de pacientes com câncer de pulmão submetidos à radioterapia. Essa acurácia melhorou a radioterapia para câncer de pulmão principalmente porque permite a definição precisa dos limites do(s) tumor(es), evitando assim a definição errônea do alvo (mistargeting) e a irradiação desnecessária de estruturas adjacentes (Figura 4). Por exemplo, estudos recentes demonstraram que o uso da PET/TC no planejamento da radioterapia foi capaz de reduzir de forma consistente as doses de radiação para lesões esofágicas e pulmonares.(19,20) Além disso, a maior sensibilidade da FDG-PET (em comparação à TC) na detecção de linfonodos mediastinais anormais permitiu que a PET/TC fosse usada na delineação de volumes alvos utilizando contorno anatômico biológico, com resultados ainda melhores.(3)

Bottom Line: In addition, the accuracy of PET/CT has been shown to be greater than is that of conventional modalities in some scenarios, making PET/CT a valuable noninvasive method for the investigation of lung cancer.However, the interpretation of PET/CT findings presents numerous pitfalls and potential confounders.Therefore, it is imperative for pulmonologists and radiologists to familiarize themselves with the most relevant indications for and limitations of PET/CT, seeking to protect their patients from unnecessary radiation exposure and inappropriate treatment.

View Article: PubMed Central - PubMed

Affiliation: Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

ABSTRACT
The use of PET/CT imaging in the work-up and management of patients with lung cancer has greatly increased in recent decades. The ability to combine functional and anatomical information has equipped PET/CT to look into various aspects of lung cancer, allowing more precise disease staging and providing useful data during the characterization of indeterminate pulmonary nodules. In addition, the accuracy of PET/CT has been shown to be greater than is that of conventional modalities in some scenarios, making PET/CT a valuable noninvasive method for the investigation of lung cancer. However, the interpretation of PET/CT findings presents numerous pitfalls and potential confounders. Therefore, it is imperative for pulmonologists and radiologists to familiarize themselves with the most relevant indications for and limitations of PET/CT, seeking to protect their patients from unnecessary radiation exposure and inappropriate treatment. This review article aimed to summarize the basic principles, indications, cancer staging considerations, and future applications related to the use of PET/CT in lung cancer.

Show MeSH
Related in: MedlinePlus