Limits...
Six-minute walk test and respiratory muscle strength in patients with uncontrolled severe asthma: a pilot study.

Pereira LF, Mancuzo EV, Rezende CF, Côrrea Rde A - J Bras Pneumol (2015 May-Jun)

Bottom Line: No significant difference was found between the median six-minute walk distance recorded for the UCSA patients and that predicted for healthy Brazilians (512 m and 534 m, respectively; p = 0.14).During the 6MWT, there was no significant drop in SpO2.Comparing the patients treated with at least four courses of oral corticosteroids per year and those treated with three or fewer, we found no significant differences in MIP (p = 0.15) or MEP (p = 0.45).

View Article: PubMed Central - PubMed

Affiliation: Hospital das Clínicas, Federal University of Minas Gerais, Belo Horizonte, Brazil.

ABSTRACT

Objective: To evaluate respiratory muscle strength and six-minute walk test (6MWT) variables in patients with uncontrolled severe asthma (UCSA).

Methods: This was a cross-sectional study involving UCSA patients followed at a university hospital. The patients underwent 6MWT, spirometry, and measurements of respiratory muscle strength, as well as completing the Asthma Control Test (ACT). The Mann-Whitney test was used in order to analyze 6MWT variables, whereas the Kruskal-Wallis test was used to determine whether there was an association between the use of oral corticosteroids and respiratory muscle strength.

Results: We included 25 patients. Mean FEV1 was 58.8 ± 21.8% of predicted, and mean ACT score was 14.0 ± 3.9 points. No significant difference was found between the median six-minute walk distance recorded for the UCSA patients and that predicted for healthy Brazilians (512 m and 534 m, respectively; p = 0.14). During the 6MWT, there was no significant drop in SpO2. Mean MIP and MEP were normal (72.9 ± 15.2% and 67.6 ± 22.2%, respectively). Comparing the patients treated with at least four courses of oral corticosteroids per year and those treated with three or fewer, we found no significant differences in MIP (p = 0.15) or MEP (p = 0.45).

Conclusions: Our findings suggest that UCSA patients are similar to normal subjects in terms of 6MWT variables and respiratory muscle strength. The use of oral corticosteroids has no apparent impact on respiratory muscle strength.

Show MeSH

Related in: MedlinePlus

Distribuição da distância percorrida no teste de caminhada de seis minutos no grupo de pacientes (N = 25) com asma grave não controlada (DTC6-AGNC) em comparação com a mesma distância prevista para adultos brasileiros saudáveis (DTC6-AS).(18)a *Valores discrepantes. aValores expressos em mediana.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4541755&req=5

f02: Distribuição da distância percorrida no teste de caminhada de seis minutos no grupo de pacientes (N = 25) com asma grave não controlada (DTC6-AGNC) em comparação com a mesma distância prevista para adultos brasileiros saudáveis (DTC6-AS).(18)a *Valores discrepantes. aValores expressos em mediana.

Mentions: Não houve diferença significativa (p = 0,14) entre os valores medianos da DTC6 - 512 m (variação: 307,2-597,3 m) - e da DTC6 prevista para indivíduos normais - 534 m (variação: 382,6-621,3 m) - (Figura 1).


Six-minute walk test and respiratory muscle strength in patients with uncontrolled severe asthma: a pilot study.

Pereira LF, Mancuzo EV, Rezende CF, Côrrea Rde A - J Bras Pneumol (2015 May-Jun)

Distribuição da distância percorrida no teste de caminhada de seis minutos no grupo de pacientes (N = 25) com asma grave não controlada (DTC6-AGNC) em comparação com a mesma distância prevista para adultos brasileiros saudáveis (DTC6-AS).(18)a *Valores discrepantes. aValores expressos em mediana.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4541755&req=5

f02: Distribuição da distância percorrida no teste de caminhada de seis minutos no grupo de pacientes (N = 25) com asma grave não controlada (DTC6-AGNC) em comparação com a mesma distância prevista para adultos brasileiros saudáveis (DTC6-AS).(18)a *Valores discrepantes. aValores expressos em mediana.
Mentions: Não houve diferença significativa (p = 0,14) entre os valores medianos da DTC6 - 512 m (variação: 307,2-597,3 m) - e da DTC6 prevista para indivíduos normais - 534 m (variação: 382,6-621,3 m) - (Figura 1).

Bottom Line: No significant difference was found between the median six-minute walk distance recorded for the UCSA patients and that predicted for healthy Brazilians (512 m and 534 m, respectively; p = 0.14).During the 6MWT, there was no significant drop in SpO2.Comparing the patients treated with at least four courses of oral corticosteroids per year and those treated with three or fewer, we found no significant differences in MIP (p = 0.15) or MEP (p = 0.45).

View Article: PubMed Central - PubMed

Affiliation: Hospital das Clínicas, Federal University of Minas Gerais, Belo Horizonte, Brazil.

ABSTRACT

Objective: To evaluate respiratory muscle strength and six-minute walk test (6MWT) variables in patients with uncontrolled severe asthma (UCSA).

Methods: This was a cross-sectional study involving UCSA patients followed at a university hospital. The patients underwent 6MWT, spirometry, and measurements of respiratory muscle strength, as well as completing the Asthma Control Test (ACT). The Mann-Whitney test was used in order to analyze 6MWT variables, whereas the Kruskal-Wallis test was used to determine whether there was an association between the use of oral corticosteroids and respiratory muscle strength.

Results: We included 25 patients. Mean FEV1 was 58.8 ± 21.8% of predicted, and mean ACT score was 14.0 ± 3.9 points. No significant difference was found between the median six-minute walk distance recorded for the UCSA patients and that predicted for healthy Brazilians (512 m and 534 m, respectively; p = 0.14). During the 6MWT, there was no significant drop in SpO2. Mean MIP and MEP were normal (72.9 ± 15.2% and 67.6 ± 22.2%, respectively). Comparing the patients treated with at least four courses of oral corticosteroids per year and those treated with three or fewer, we found no significant differences in MIP (p = 0.15) or MEP (p = 0.45).

Conclusions: Our findings suggest that UCSA patients are similar to normal subjects in terms of 6MWT variables and respiratory muscle strength. The use of oral corticosteroids has no apparent impact on respiratory muscle strength.

Show MeSH
Related in: MedlinePlus