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Low CD1c + myeloid dendritic cell counts correlated with a high risk of rapid disease progression during early HIV-1 infection.

Diao Y, Geng W, Fan X, Cui H, Sun H, Jiang Y, Wang Y, Sun A, Shang H - BMC Infect. Dis. (2015)

Bottom Line: When compared with the normal controls, patients with EHI displayed significantly lower CD1c + mDC counts and IL-12 secretion and increased surface markers.CD1c + mDC counts were positively correlated with CD4+ T cell counts and inversely associated with viral loads.IL-12 secretion was only positively associated with CD4+ T cell counts.

View Article: PubMed Central - PubMed

Affiliation: Department of Laboratory Medicine, The First Affiliated Hospital, China Medical University, Shenyang, Liaoning Province, China. cmudyy@163.com.

ABSTRACT

Background: During early HIV-1 infection (EHI), the interaction between the immune response and the virus determines disease progression. Although CD1c + myeloid dendritic cells (mDCs) can trigger the immune response, the relationship between CD1c + mDC alteration and disease progression has not yet been defined.

Methods: EHI changes in CD1c + mDC counts, surface marker (CD40, CD86, CD83) expression, and IL-12 secretion were assessed by flow cytometry in 29 patients.

Results: When compared with the normal controls, patients with EHI displayed significantly lower CD1c + mDC counts and IL-12 secretion and increased surface markers. CD1c + mDC counts were positively correlated with CD4+ T cell counts and inversely associated with viral loads. IL-12 secretion was only positively associated with CD4+ T cell counts. Rapid progressors had lower counts, CD86 expression, and IL-12 secretion of CD1c + mDCs comparing with typical progressors. Kaplan-Meier analysis and Cox regression models suggested patients with low CD1c + mDC counts (<10 cells/μL) had a 4-fold higher risk of rapid disease progression than those with high CD1c + mDC counts. However, no relationship was found between surface markers or IL-12 secretion and disease progression.

Conclusions: During EHI, patients with low CD1c + mDC counts were more likely to experience rapid disease progression than those with high CD1c + mDC counts.

No MeSH data available.


Related in: MedlinePlus

The correlation between CD1c + mDC counts or IL-12 and CD4+ T cell counts or viral loads. a CD1c + mDC counts in individuals with EHI and in NCs, and correlations between CD1c + mDC counts and corresponding CD4+ T cell counts or viral loads. b Coreceptor (CD86, CD40 and CD83) expression of CD1c + mDC in individuals with EHI and in NCs. c IL-12 secretion in individuals with EHI and in NCs, and associations between intracellular IL-12 secretion and corresponding CD4 + T cell counts or viral loads
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Fig1: The correlation between CD1c + mDC counts or IL-12 and CD4+ T cell counts or viral loads. a CD1c + mDC counts in individuals with EHI and in NCs, and correlations between CD1c + mDC counts and corresponding CD4+ T cell counts or viral loads. b Coreceptor (CD86, CD40 and CD83) expression of CD1c + mDC in individuals with EHI and in NCs. c IL-12 secretion in individuals with EHI and in NCs, and associations between intracellular IL-12 secretion and corresponding CD4 + T cell counts or viral loads

Mentions: To assess whether changes in CD1c + mDC counts, surface marker expression, and IL-12 secretion would be evident during EHI, we found that patients with EHI had significantly lower CD1c + mDC counts and IL-12 secretion levels compared with NCs (p = 0.018, p = 0.010) (Fig. 1a and c). CD1c + mDC had significantly higher expression of CD86, CD40, and CD83 during EHI compared with CD1c + mDC of NCs (p = 0.001, p = 0.037, and p < 0.001, respectively) (Fig. 1b).Fig. 1


Low CD1c + myeloid dendritic cell counts correlated with a high risk of rapid disease progression during early HIV-1 infection.

Diao Y, Geng W, Fan X, Cui H, Sun H, Jiang Y, Wang Y, Sun A, Shang H - BMC Infect. Dis. (2015)

The correlation between CD1c + mDC counts or IL-12 and CD4+ T cell counts or viral loads. a CD1c + mDC counts in individuals with EHI and in NCs, and correlations between CD1c + mDC counts and corresponding CD4+ T cell counts or viral loads. b Coreceptor (CD86, CD40 and CD83) expression of CD1c + mDC in individuals with EHI and in NCs. c IL-12 secretion in individuals with EHI and in NCs, and associations between intracellular IL-12 secretion and corresponding CD4 + T cell counts or viral loads
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4541738&req=5

Fig1: The correlation between CD1c + mDC counts or IL-12 and CD4+ T cell counts or viral loads. a CD1c + mDC counts in individuals with EHI and in NCs, and correlations between CD1c + mDC counts and corresponding CD4+ T cell counts or viral loads. b Coreceptor (CD86, CD40 and CD83) expression of CD1c + mDC in individuals with EHI and in NCs. c IL-12 secretion in individuals with EHI and in NCs, and associations between intracellular IL-12 secretion and corresponding CD4 + T cell counts or viral loads
Mentions: To assess whether changes in CD1c + mDC counts, surface marker expression, and IL-12 secretion would be evident during EHI, we found that patients with EHI had significantly lower CD1c + mDC counts and IL-12 secretion levels compared with NCs (p = 0.018, p = 0.010) (Fig. 1a and c). CD1c + mDC had significantly higher expression of CD86, CD40, and CD83 during EHI compared with CD1c + mDC of NCs (p = 0.001, p = 0.037, and p < 0.001, respectively) (Fig. 1b).Fig. 1

Bottom Line: When compared with the normal controls, patients with EHI displayed significantly lower CD1c + mDC counts and IL-12 secretion and increased surface markers.CD1c + mDC counts were positively correlated with CD4+ T cell counts and inversely associated with viral loads.IL-12 secretion was only positively associated with CD4+ T cell counts.

View Article: PubMed Central - PubMed

Affiliation: Department of Laboratory Medicine, The First Affiliated Hospital, China Medical University, Shenyang, Liaoning Province, China. cmudyy@163.com.

ABSTRACT

Background: During early HIV-1 infection (EHI), the interaction between the immune response and the virus determines disease progression. Although CD1c + myeloid dendritic cells (mDCs) can trigger the immune response, the relationship between CD1c + mDC alteration and disease progression has not yet been defined.

Methods: EHI changes in CD1c + mDC counts, surface marker (CD40, CD86, CD83) expression, and IL-12 secretion were assessed by flow cytometry in 29 patients.

Results: When compared with the normal controls, patients with EHI displayed significantly lower CD1c + mDC counts and IL-12 secretion and increased surface markers. CD1c + mDC counts were positively correlated with CD4+ T cell counts and inversely associated with viral loads. IL-12 secretion was only positively associated with CD4+ T cell counts. Rapid progressors had lower counts, CD86 expression, and IL-12 secretion of CD1c + mDCs comparing with typical progressors. Kaplan-Meier analysis and Cox regression models suggested patients with low CD1c + mDC counts (<10 cells/μL) had a 4-fold higher risk of rapid disease progression than those with high CD1c + mDC counts. However, no relationship was found between surface markers or IL-12 secretion and disease progression.

Conclusions: During EHI, patients with low CD1c + mDC counts were more likely to experience rapid disease progression than those with high CD1c + mDC counts.

No MeSH data available.


Related in: MedlinePlus