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Divergent cerebrospinal fluid cytokine network induced by non-viral and different viral infections on the central nervous system.

Bastos MS, Coelho-Dos-Reis JG, Zauli DA, Naveca FG, Monte RL, Pimentel JP, Macário VM, da Silva NL, Peruhype-Magalhães V, Pascoal-Xavier MA, Guimaraes A, Carvalho AT, Malheiro A, Martins-Filho OA, Mourão MP - BMC Infect. Dis. (2015)

Bottom Line: The results demonstrate that an altered biochemical profile alongside increased cellularity in the cerebrospinal fluid is a feature of patients with meningoencephalitis that are not associated with the detection of virus in the CNS (P < 0.05).In the case of Enterovirus infection (n = 13), meningoencephalitis elicits robust intrathecal pro-inflammatory cytokine pattern and elevated cellularity when compared to herpesvirus (n = 15) and Arbovirus (n = 5) viral infections (P < 0.05).Differences in the cytokine profile of the CSF may be unique if distinct, viral or presumably non-viral pathways initially trigger the inflammatory response in the CNS.

View Article: PubMed Central - PubMed

Affiliation: Tropical Medicine Foundation Dr. Heitor Vieira Dourado, Manaus, AM, Brazil. michelebastos01@gmail.com.

ABSTRACT

Background: Meningoencephalitis is one of the most common disorders of the central nervous system (CNS) worldwide. Viral meningoencephalitis differs from bacterial meningitis in several aspects. In some developing countries, bacterial meningitis has appropriate clinical management and chemotherapy is available. Virus-associated and virus not detected meningoencephalitis are treatable, however, they may cause death in a few cases. The knowledge of how mediators of inflammation can induce disease would contribute for the design of affordable therapeutic strategies, as well as to the diagnosis of virus not detected and viral meningoencephalitis. Cytokine-induced inflammation to CNS requires several factors that are not fully understood yet.

Methods: Considering this, several cytokines were measured in the cerebrospinal fluid (CSF) of patients with undiagnosed and viral meningoencephalitis, and these were correlated with cellularity in the CSF.

Results: The results demonstrate that an altered biochemical profile alongside increased cellularity in the cerebrospinal fluid is a feature of patients with meningoencephalitis that are not associated with the detection of virus in the CNS (P < 0.05). Moreover, HIV-positive patients (n = 10) that evolve with meningoencephalitis display a distinct biochemical/cytological profile (P < 0.05) in the cerebrospinal fluid. Meningoencephalitis brings about a prominent intrathecal cytokine storm regardless of the detection of virus as presumable etiological agent. In the case of Enterovirus infection (n = 13), meningoencephalitis elicits robust intrathecal pro-inflammatory cytokine pattern and elevated cellularity when compared to herpesvirus (n = 15) and Arbovirus (n = 5) viral infections (P < 0.05).

Conclusion: Differences in the cytokine profile of the CSF may be unique if distinct, viral or presumably non-viral pathways initially trigger the inflammatory response in the CNS.

No MeSH data available.


Related in: MedlinePlus

CSF cytokine networks in meningoencephalitis patients with high and low cellularity. Association among cytokines is displayed as interactive nets for virus not detected (gray) and virus-positive (black) meningoencephalitis patients. Each connection corresponds to statistical positive correlation between the cytokine pairs (p < 0.05)
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Fig5: CSF cytokine networks in meningoencephalitis patients with high and low cellularity. Association among cytokines is displayed as interactive nets for virus not detected (gray) and virus-positive (black) meningoencephalitis patients. Each connection corresponds to statistical positive correlation between the cytokine pairs (p < 0.05)

Mentions: Considering the intertwined collaboration between cellularity and cytokines and among the cytokines to produce the inflammatory response in meningoencephalitis, an interactive analysis was performed, seeking for correlations between the biomarkers tested. Networks of cytokines in high and low cellularity groups were built and are displayed in Fig. 5. Results in gray circle show data regarding undiagnosed meningoencephalitis, whereas results in black rectangles represent virus-positive meningitis.Fig. 5


Divergent cerebrospinal fluid cytokine network induced by non-viral and different viral infections on the central nervous system.

Bastos MS, Coelho-Dos-Reis JG, Zauli DA, Naveca FG, Monte RL, Pimentel JP, Macário VM, da Silva NL, Peruhype-Magalhães V, Pascoal-Xavier MA, Guimaraes A, Carvalho AT, Malheiro A, Martins-Filho OA, Mourão MP - BMC Infect. Dis. (2015)

CSF cytokine networks in meningoencephalitis patients with high and low cellularity. Association among cytokines is displayed as interactive nets for virus not detected (gray) and virus-positive (black) meningoencephalitis patients. Each connection corresponds to statistical positive correlation between the cytokine pairs (p < 0.05)
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4541733&req=5

Fig5: CSF cytokine networks in meningoencephalitis patients with high and low cellularity. Association among cytokines is displayed as interactive nets for virus not detected (gray) and virus-positive (black) meningoencephalitis patients. Each connection corresponds to statistical positive correlation between the cytokine pairs (p < 0.05)
Mentions: Considering the intertwined collaboration between cellularity and cytokines and among the cytokines to produce the inflammatory response in meningoencephalitis, an interactive analysis was performed, seeking for correlations between the biomarkers tested. Networks of cytokines in high and low cellularity groups were built and are displayed in Fig. 5. Results in gray circle show data regarding undiagnosed meningoencephalitis, whereas results in black rectangles represent virus-positive meningitis.Fig. 5

Bottom Line: The results demonstrate that an altered biochemical profile alongside increased cellularity in the cerebrospinal fluid is a feature of patients with meningoencephalitis that are not associated with the detection of virus in the CNS (P < 0.05).In the case of Enterovirus infection (n = 13), meningoencephalitis elicits robust intrathecal pro-inflammatory cytokine pattern and elevated cellularity when compared to herpesvirus (n = 15) and Arbovirus (n = 5) viral infections (P < 0.05).Differences in the cytokine profile of the CSF may be unique if distinct, viral or presumably non-viral pathways initially trigger the inflammatory response in the CNS.

View Article: PubMed Central - PubMed

Affiliation: Tropical Medicine Foundation Dr. Heitor Vieira Dourado, Manaus, AM, Brazil. michelebastos01@gmail.com.

ABSTRACT

Background: Meningoencephalitis is one of the most common disorders of the central nervous system (CNS) worldwide. Viral meningoencephalitis differs from bacterial meningitis in several aspects. In some developing countries, bacterial meningitis has appropriate clinical management and chemotherapy is available. Virus-associated and virus not detected meningoencephalitis are treatable, however, they may cause death in a few cases. The knowledge of how mediators of inflammation can induce disease would contribute for the design of affordable therapeutic strategies, as well as to the diagnosis of virus not detected and viral meningoencephalitis. Cytokine-induced inflammation to CNS requires several factors that are not fully understood yet.

Methods: Considering this, several cytokines were measured in the cerebrospinal fluid (CSF) of patients with undiagnosed and viral meningoencephalitis, and these were correlated with cellularity in the CSF.

Results: The results demonstrate that an altered biochemical profile alongside increased cellularity in the cerebrospinal fluid is a feature of patients with meningoencephalitis that are not associated with the detection of virus in the CNS (P < 0.05). Moreover, HIV-positive patients (n = 10) that evolve with meningoencephalitis display a distinct biochemical/cytological profile (P < 0.05) in the cerebrospinal fluid. Meningoencephalitis brings about a prominent intrathecal cytokine storm regardless of the detection of virus as presumable etiological agent. In the case of Enterovirus infection (n = 13), meningoencephalitis elicits robust intrathecal pro-inflammatory cytokine pattern and elevated cellularity when compared to herpesvirus (n = 15) and Arbovirus (n = 5) viral infections (P < 0.05).

Conclusion: Differences in the cytokine profile of the CSF may be unique if distinct, viral or presumably non-viral pathways initially trigger the inflammatory response in the CNS.

No MeSH data available.


Related in: MedlinePlus