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Characteristics of patients with primary open angle glaucoma and normal tension glaucoma at a university hospital: a cross-sectional retrospective study.

Yokoyama Y, Maruyama K, Konno H, Hashimoto S, Takahashi M, Kayaba H, Kokubun T, Nakazawa T - BMC Res Notes (2015)

Bottom Line: Interestingly, MD slope was slightly steeper in the low-IOP group than in the high-IOP group, although the difference was not statistically significant (-0.85 vs. -0.70 dB/year, P = 0.31).Baseline MD was significantly worse in the group with MD slope <-1.0 dB/year than in the group with MD slope ≥-1.0 dB/year (-11.56 vs. -7.64 dB/year, P < 0.01).We identified characteristics of glaucoma patients at a university hospital that may reflect the specialized nature of such an institution.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Tohoku University Graduate School of Medicine, 1-1, Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8574, Japan. yu-yokoyama@oph.med.tohoku.ac.jp.

ABSTRACT

Background: The characteristics of glaucoma patients and their response to therapy may differ by institution, region and country. Therefore, clinicians should understand the distinctiveness of their patients. Here, we profile primary open angle glaucoma (POAG) and normal tension glaucoma (NTG) patients at a major university hospital in Japan.

Methods: This study included 523 eyes from 523 POAG and NTG patients who underwent full clinical ophthalmologic evaluations at Tohoku University Hospital. Clinical characteristics such as age, sex, visual acuity, intraocular pressure, Humphrey field analyzer-measured mean deviation (MD) and MD slope were collected retrospectively. MD slope was calculated from MD data that included the first baseline measurement of MD and 4 subsequent, consecutive, reliable measurements of MD. Refractive error was analyzed in a subgroup with no history of refractive surgery, including intraocular lens implantation. Patient characteristics were analyzed separately in the groups of patients with low (<15 mmHg) and high IOP (≥15 mmHg) and in the groups with MD slope ≥-1.0 and <-1.0 dB/year.

Results: Mean age, visual acuity (median), IOP, pre-treatment IOP (from patient history), refractive error and MD were 61.7 ± 12.5 years, -0.08 (interquartile range -0.08 to 0.05) LogMAR, 13.87 ± 3.37 mmHg, 18.35 ± 6.26 mmHg, -4.48 ± 3.81 diopters and -11.73 ± 8.83 dB, respectively. POAG and NTG patients had significant differences in mean age (63.4 ± 12.4 vs. 60.7 ± 12.5 years, P < 0.01), visual acuity, IOP (14.95 ± 4.20 vs. 13.21 ± 2.54 mmHg, P < 0.01) and MD (-13.85 ± 9.32 vs. -10.45 ± 8.27 dB, P < 0.01). Interestingly, MD slope was slightly steeper in the low-IOP group than in the high-IOP group, although the difference was not statistically significant (-0.85 vs. -0.70 dB/year, P = 0.31). Baseline MD was significantly worse in the group with MD slope <-1.0 dB/year than in the group with MD slope ≥-1.0 dB/year (-11.56 vs. -7.64 dB/year, P < 0.01).

Conclusions: We identified characteristics of glaucoma patients at a university hospital that may reflect the specialized nature of such an institution.

No MeSH data available.


Related in: MedlinePlus

MD slopes in the low-IOP and high-IOP groups. a Histogram of MD slope in each group. Even with IOP <15 mmHg, 48 % of patients had progressive visual field defects with MD slope <−1.0 dB/year. In addition, 26 % of these patients had MD slope <−1.5 dB/year. b Scatter plot of IOP and MD slope. There was no significant correlation between treated IOP and MD slope (R2 = 0.00, P = 0.93)
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Fig4: MD slopes in the low-IOP and high-IOP groups. a Histogram of MD slope in each group. Even with IOP <15 mmHg, 48 % of patients had progressive visual field defects with MD slope <−1.0 dB/year. In addition, 26 % of these patients had MD slope <−1.5 dB/year. b Scatter plot of IOP and MD slope. There was no significant correlation between treated IOP and MD slope (R2 = 0.00, P = 0.93)

Mentions: Clinical characteristics were analyzed in the low-IOP (<15 mmHg) and high-IOP (≥15 mmHg) groups (Table 2). This analysis revealed that the eyes with low IOP had more severe glaucomatous damage, with a relatively steeper MD slope, although the difference was not statistically significant (P value = 0.31). Furthermore, an analysis of clinical characteristics in the groups with MD slope <−1.0 and ≥−1.0 dB/year groups (Table 3) revealed significant differences in visual acuity, MD, and baseline MD between the two groups. A histogram of the MD slope is shown in Fig. 4a. Among our patients, visual field deterioration progressed at more than −1.0 dB/year in 48 % of eyes with IOP <15 mmHg. Moreover, we did not observe a correlation between IOP and MD slope (R2 = 0.00, P = 0.93; Fig. 4b).Table 3


Characteristics of patients with primary open angle glaucoma and normal tension glaucoma at a university hospital: a cross-sectional retrospective study.

Yokoyama Y, Maruyama K, Konno H, Hashimoto S, Takahashi M, Kayaba H, Kokubun T, Nakazawa T - BMC Res Notes (2015)

MD slopes in the low-IOP and high-IOP groups. a Histogram of MD slope in each group. Even with IOP <15 mmHg, 48 % of patients had progressive visual field defects with MD slope <−1.0 dB/year. In addition, 26 % of these patients had MD slope <−1.5 dB/year. b Scatter plot of IOP and MD slope. There was no significant correlation between treated IOP and MD slope (R2 = 0.00, P = 0.93)
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4541728&req=5

Fig4: MD slopes in the low-IOP and high-IOP groups. a Histogram of MD slope in each group. Even with IOP <15 mmHg, 48 % of patients had progressive visual field defects with MD slope <−1.0 dB/year. In addition, 26 % of these patients had MD slope <−1.5 dB/year. b Scatter plot of IOP and MD slope. There was no significant correlation between treated IOP and MD slope (R2 = 0.00, P = 0.93)
Mentions: Clinical characteristics were analyzed in the low-IOP (<15 mmHg) and high-IOP (≥15 mmHg) groups (Table 2). This analysis revealed that the eyes with low IOP had more severe glaucomatous damage, with a relatively steeper MD slope, although the difference was not statistically significant (P value = 0.31). Furthermore, an analysis of clinical characteristics in the groups with MD slope <−1.0 and ≥−1.0 dB/year groups (Table 3) revealed significant differences in visual acuity, MD, and baseline MD between the two groups. A histogram of the MD slope is shown in Fig. 4a. Among our patients, visual field deterioration progressed at more than −1.0 dB/year in 48 % of eyes with IOP <15 mmHg. Moreover, we did not observe a correlation between IOP and MD slope (R2 = 0.00, P = 0.93; Fig. 4b).Table 3

Bottom Line: Interestingly, MD slope was slightly steeper in the low-IOP group than in the high-IOP group, although the difference was not statistically significant (-0.85 vs. -0.70 dB/year, P = 0.31).Baseline MD was significantly worse in the group with MD slope <-1.0 dB/year than in the group with MD slope ≥-1.0 dB/year (-11.56 vs. -7.64 dB/year, P < 0.01).We identified characteristics of glaucoma patients at a university hospital that may reflect the specialized nature of such an institution.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Tohoku University Graduate School of Medicine, 1-1, Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8574, Japan. yu-yokoyama@oph.med.tohoku.ac.jp.

ABSTRACT

Background: The characteristics of glaucoma patients and their response to therapy may differ by institution, region and country. Therefore, clinicians should understand the distinctiveness of their patients. Here, we profile primary open angle glaucoma (POAG) and normal tension glaucoma (NTG) patients at a major university hospital in Japan.

Methods: This study included 523 eyes from 523 POAG and NTG patients who underwent full clinical ophthalmologic evaluations at Tohoku University Hospital. Clinical characteristics such as age, sex, visual acuity, intraocular pressure, Humphrey field analyzer-measured mean deviation (MD) and MD slope were collected retrospectively. MD slope was calculated from MD data that included the first baseline measurement of MD and 4 subsequent, consecutive, reliable measurements of MD. Refractive error was analyzed in a subgroup with no history of refractive surgery, including intraocular lens implantation. Patient characteristics were analyzed separately in the groups of patients with low (<15 mmHg) and high IOP (≥15 mmHg) and in the groups with MD slope ≥-1.0 and <-1.0 dB/year.

Results: Mean age, visual acuity (median), IOP, pre-treatment IOP (from patient history), refractive error and MD were 61.7 ± 12.5 years, -0.08 (interquartile range -0.08 to 0.05) LogMAR, 13.87 ± 3.37 mmHg, 18.35 ± 6.26 mmHg, -4.48 ± 3.81 diopters and -11.73 ± 8.83 dB, respectively. POAG and NTG patients had significant differences in mean age (63.4 ± 12.4 vs. 60.7 ± 12.5 years, P < 0.01), visual acuity, IOP (14.95 ± 4.20 vs. 13.21 ± 2.54 mmHg, P < 0.01) and MD (-13.85 ± 9.32 vs. -10.45 ± 8.27 dB, P < 0.01). Interestingly, MD slope was slightly steeper in the low-IOP group than in the high-IOP group, although the difference was not statistically significant (-0.85 vs. -0.70 dB/year, P = 0.31). Baseline MD was significantly worse in the group with MD slope <-1.0 dB/year than in the group with MD slope ≥-1.0 dB/year (-11.56 vs. -7.64 dB/year, P < 0.01).

Conclusions: We identified characteristics of glaucoma patients at a university hospital that may reflect the specialized nature of such an institution.

No MeSH data available.


Related in: MedlinePlus