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Characteristics of patients with primary open angle glaucoma and normal tension glaucoma at a university hospital: a cross-sectional retrospective study.

Yokoyama Y, Maruyama K, Konno H, Hashimoto S, Takahashi M, Kayaba H, Kokubun T, Nakazawa T - BMC Res Notes (2015)

Bottom Line: Interestingly, MD slope was slightly steeper in the low-IOP group than in the high-IOP group, although the difference was not statistically significant (-0.85 vs. -0.70 dB/year, P = 0.31).Baseline MD was significantly worse in the group with MD slope <-1.0 dB/year than in the group with MD slope ≥-1.0 dB/year (-11.56 vs. -7.64 dB/year, P < 0.01).We identified characteristics of glaucoma patients at a university hospital that may reflect the specialized nature of such an institution.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Tohoku University Graduate School of Medicine, 1-1, Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8574, Japan. yu-yokoyama@oph.med.tohoku.ac.jp.

ABSTRACT

Background: The characteristics of glaucoma patients and their response to therapy may differ by institution, region and country. Therefore, clinicians should understand the distinctiveness of their patients. Here, we profile primary open angle glaucoma (POAG) and normal tension glaucoma (NTG) patients at a major university hospital in Japan.

Methods: This study included 523 eyes from 523 POAG and NTG patients who underwent full clinical ophthalmologic evaluations at Tohoku University Hospital. Clinical characteristics such as age, sex, visual acuity, intraocular pressure, Humphrey field analyzer-measured mean deviation (MD) and MD slope were collected retrospectively. MD slope was calculated from MD data that included the first baseline measurement of MD and 4 subsequent, consecutive, reliable measurements of MD. Refractive error was analyzed in a subgroup with no history of refractive surgery, including intraocular lens implantation. Patient characteristics were analyzed separately in the groups of patients with low (<15 mmHg) and high IOP (≥15 mmHg) and in the groups with MD slope ≥-1.0 and <-1.0 dB/year.

Results: Mean age, visual acuity (median), IOP, pre-treatment IOP (from patient history), refractive error and MD were 61.7 ± 12.5 years, -0.08 (interquartile range -0.08 to 0.05) LogMAR, 13.87 ± 3.37 mmHg, 18.35 ± 6.26 mmHg, -4.48 ± 3.81 diopters and -11.73 ± 8.83 dB, respectively. POAG and NTG patients had significant differences in mean age (63.4 ± 12.4 vs. 60.7 ± 12.5 years, P < 0.01), visual acuity, IOP (14.95 ± 4.20 vs. 13.21 ± 2.54 mmHg, P < 0.01) and MD (-13.85 ± 9.32 vs. -10.45 ± 8.27 dB, P < 0.01). Interestingly, MD slope was slightly steeper in the low-IOP group than in the high-IOP group, although the difference was not statistically significant (-0.85 vs. -0.70 dB/year, P = 0.31). Baseline MD was significantly worse in the group with MD slope <-1.0 dB/year than in the group with MD slope ≥-1.0 dB/year (-11.56 vs. -7.64 dB/year, P < 0.01).

Conclusions: We identified characteristics of glaucoma patients at a university hospital that may reflect the specialized nature of such an institution.

No MeSH data available.


Related in: MedlinePlus

Histogram of intraocular pressure. IOP intraocular pressure
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Fig2: Histogram of intraocular pressure. IOP intraocular pressure

Mentions: The characteristics of the 523 eyes of 523 patients with POAG or NTG included in this study are shown in Table 1. The patients had a mean age of 61.7 ± 12.5 years (ranging from 21 to 87 years; distribution shown in Fig. 1). The sex ratio was 281:242 (male:female). Median visual acuity (LogMAR), IOP, HFA MD, and HFA pattern standard deviation were −0.08 (interquartile range −0.08 to 0.05), 13.87 ± 3.37 mmHg, 11.73 ± 8.83 and 8.84 ± 4.24 dB, respectively (Table 1). The peak of the IOP distribution curve was shifted downwards despite the presence of glaucoma in the patients, reflecting their use of IOP-lowering treatments (Fig. 2). Our data for the distribution of MD was even, (Fig. 3), reflecting the high percentage (41 %) of patients in our study with severe visual field damage (<−12 dB). There were differences between the POAG and NTG patients in age, sex, visual acuity, IOP and MD (Table 1). The POAG patients had significantly higher IOP than the NTG patients (14.95 vs. 13.21 mmHg). The POAG patients also had more advanced visual field deterioration than the NTG patients (−13.85 vs. −10.38 dB). A trend analysis of MD in 138 eligible eyes revealed that average MD slope was −0.77 dB/year (Table 2). In these patients, mean IOP and mean MD were 14.30 ± 3.44 mmHg and −10.82 ± 7.96 dB. In these eyes, the mean pre-treatment IOP (obtained from the patients’ clinical history) was 18.35 ± 6.26 mmHg.Table 1


Characteristics of patients with primary open angle glaucoma and normal tension glaucoma at a university hospital: a cross-sectional retrospective study.

Yokoyama Y, Maruyama K, Konno H, Hashimoto S, Takahashi M, Kayaba H, Kokubun T, Nakazawa T - BMC Res Notes (2015)

Histogram of intraocular pressure. IOP intraocular pressure
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4541728&req=5

Fig2: Histogram of intraocular pressure. IOP intraocular pressure
Mentions: The characteristics of the 523 eyes of 523 patients with POAG or NTG included in this study are shown in Table 1. The patients had a mean age of 61.7 ± 12.5 years (ranging from 21 to 87 years; distribution shown in Fig. 1). The sex ratio was 281:242 (male:female). Median visual acuity (LogMAR), IOP, HFA MD, and HFA pattern standard deviation were −0.08 (interquartile range −0.08 to 0.05), 13.87 ± 3.37 mmHg, 11.73 ± 8.83 and 8.84 ± 4.24 dB, respectively (Table 1). The peak of the IOP distribution curve was shifted downwards despite the presence of glaucoma in the patients, reflecting their use of IOP-lowering treatments (Fig. 2). Our data for the distribution of MD was even, (Fig. 3), reflecting the high percentage (41 %) of patients in our study with severe visual field damage (<−12 dB). There were differences between the POAG and NTG patients in age, sex, visual acuity, IOP and MD (Table 1). The POAG patients had significantly higher IOP than the NTG patients (14.95 vs. 13.21 mmHg). The POAG patients also had more advanced visual field deterioration than the NTG patients (−13.85 vs. −10.38 dB). A trend analysis of MD in 138 eligible eyes revealed that average MD slope was −0.77 dB/year (Table 2). In these patients, mean IOP and mean MD were 14.30 ± 3.44 mmHg and −10.82 ± 7.96 dB. In these eyes, the mean pre-treatment IOP (obtained from the patients’ clinical history) was 18.35 ± 6.26 mmHg.Table 1

Bottom Line: Interestingly, MD slope was slightly steeper in the low-IOP group than in the high-IOP group, although the difference was not statistically significant (-0.85 vs. -0.70 dB/year, P = 0.31).Baseline MD was significantly worse in the group with MD slope <-1.0 dB/year than in the group with MD slope ≥-1.0 dB/year (-11.56 vs. -7.64 dB/year, P < 0.01).We identified characteristics of glaucoma patients at a university hospital that may reflect the specialized nature of such an institution.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Tohoku University Graduate School of Medicine, 1-1, Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8574, Japan. yu-yokoyama@oph.med.tohoku.ac.jp.

ABSTRACT

Background: The characteristics of glaucoma patients and their response to therapy may differ by institution, region and country. Therefore, clinicians should understand the distinctiveness of their patients. Here, we profile primary open angle glaucoma (POAG) and normal tension glaucoma (NTG) patients at a major university hospital in Japan.

Methods: This study included 523 eyes from 523 POAG and NTG patients who underwent full clinical ophthalmologic evaluations at Tohoku University Hospital. Clinical characteristics such as age, sex, visual acuity, intraocular pressure, Humphrey field analyzer-measured mean deviation (MD) and MD slope were collected retrospectively. MD slope was calculated from MD data that included the first baseline measurement of MD and 4 subsequent, consecutive, reliable measurements of MD. Refractive error was analyzed in a subgroup with no history of refractive surgery, including intraocular lens implantation. Patient characteristics were analyzed separately in the groups of patients with low (<15 mmHg) and high IOP (≥15 mmHg) and in the groups with MD slope ≥-1.0 and <-1.0 dB/year.

Results: Mean age, visual acuity (median), IOP, pre-treatment IOP (from patient history), refractive error and MD were 61.7 ± 12.5 years, -0.08 (interquartile range -0.08 to 0.05) LogMAR, 13.87 ± 3.37 mmHg, 18.35 ± 6.26 mmHg, -4.48 ± 3.81 diopters and -11.73 ± 8.83 dB, respectively. POAG and NTG patients had significant differences in mean age (63.4 ± 12.4 vs. 60.7 ± 12.5 years, P < 0.01), visual acuity, IOP (14.95 ± 4.20 vs. 13.21 ± 2.54 mmHg, P < 0.01) and MD (-13.85 ± 9.32 vs. -10.45 ± 8.27 dB, P < 0.01). Interestingly, MD slope was slightly steeper in the low-IOP group than in the high-IOP group, although the difference was not statistically significant (-0.85 vs. -0.70 dB/year, P = 0.31). Baseline MD was significantly worse in the group with MD slope <-1.0 dB/year than in the group with MD slope ≥-1.0 dB/year (-11.56 vs. -7.64 dB/year, P < 0.01).

Conclusions: We identified characteristics of glaucoma patients at a university hospital that may reflect the specialized nature of such an institution.

No MeSH data available.


Related in: MedlinePlus