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Re-evaluation of diagnostic parameters is crucial for obtaining accurate data on idiopathic pulmonary fibrosis.

Kaunisto J, Kelloniemi K, Sutinen E, Hodgson U, Piilonen A, Kaarteenaho R, Mäkitaro R, Purokivi M, Lappi-Blanco E, Saarelainen S, Kankaanranta H, Mursu A, Kanervisto M, Salomaa ER, Myllärniemi M - BMC Pulm Med (2015)

Bottom Line: We present here results limited to five university hospitals.Our results suggest that hospital registries are inaccurate for epidemiological studies unless patients are carefully re-evaluated.Smoking in patients with IPF was less common than in previous reports.

View Article: PubMed Central - PubMed

Affiliation: Division of Medicine, Pulmonary Diseases, Turku University Hospital, University of Turku, Turku, Finland. jakrja@utu.fi.

ABSTRACT

Background: The FinnishIPF registry is a prospective, longitudinal national registry study on the epidemiology of idiopathic pulmonary fibrosis (IPF). It was designed to describe the characteristics, management and prognosis of prevalent and incident IPF patients. The study was initiated in 2012.

Methods: We present here results limited to five university hospitals. Patients with IPF were screened from hospital registries using ICD-10 diagnosis codes J84.1 and J84.9. All patients who gave informed consent were included and evaluated using novel diagnostic criteria. Point prevalence on the 31(st) of December in 2012 was calculated using the reported population in each university hospital city as the denominator.

Results: Patients with ICD-10 codes J84.1 and J84.9 yielded a heterogeneous group - on the basis of patient records assessed by pulmonologists only 20-30 % of the cases were IPF. After clinical, radiological and histological re-evaluation 111 of 123 (90 %) of patients fulfilled the clinical criteria of IPF. The estimated prevalence of IPF was 8.6 cases/100 000. 60.4 % were men. Forty four percent of the patients were never-smokers. At diagnosis, the patients' mean age was 73.5 years and mean FVC was 80.4 % and DLCO 57.3 % of predicted.

Conclusions: Our results suggest that hospital registries are inaccurate for epidemiological studies unless patients are carefully re-evaluated. IPF is diagnosed in Finland at a stage when lung function is still quite well preserved. Smoking in patients with IPF was less common than in previous reports.

No MeSH data available.


Related in: MedlinePlus

The geographical location and areas of the five university hospital cities in Finland where the cohort was collected and their population. The number of people living in these cities was 1.29 million and it represented 24 % of the total population in Finland
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Fig1: The geographical location and areas of the five university hospital cities in Finland where the cohort was collected and their population. The number of people living in these cities was 1.29 million and it represented 24 % of the total population in Finland

Mentions: In order to evaluate systematically the nationwide prevalence of IPF in different geographical areas, we narrowed the study population to five university hospital cities and their populations at the end of the year 2012. The university hospitals represent tertiary hospitals, the most specialized level of public health care. All IPF patients who gave informed consent and lived during 2012 in the university hospital cities Helsinki, Turku, Tampere, Kuopio, or Oulu (see Fig. 1 for geographical location) were included. In Finland, patients are referred to specialist centers according to their living address and practically all IPF patients are initially evaluated at the public health care system.Fig. 1


Re-evaluation of diagnostic parameters is crucial for obtaining accurate data on idiopathic pulmonary fibrosis.

Kaunisto J, Kelloniemi K, Sutinen E, Hodgson U, Piilonen A, Kaarteenaho R, Mäkitaro R, Purokivi M, Lappi-Blanco E, Saarelainen S, Kankaanranta H, Mursu A, Kanervisto M, Salomaa ER, Myllärniemi M - BMC Pulm Med (2015)

The geographical location and areas of the five university hospital cities in Finland where the cohort was collected and their population. The number of people living in these cities was 1.29 million and it represented 24 % of the total population in Finland
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4541726&req=5

Fig1: The geographical location and areas of the five university hospital cities in Finland where the cohort was collected and their population. The number of people living in these cities was 1.29 million and it represented 24 % of the total population in Finland
Mentions: In order to evaluate systematically the nationwide prevalence of IPF in different geographical areas, we narrowed the study population to five university hospital cities and their populations at the end of the year 2012. The university hospitals represent tertiary hospitals, the most specialized level of public health care. All IPF patients who gave informed consent and lived during 2012 in the university hospital cities Helsinki, Turku, Tampere, Kuopio, or Oulu (see Fig. 1 for geographical location) were included. In Finland, patients are referred to specialist centers according to their living address and practically all IPF patients are initially evaluated at the public health care system.Fig. 1

Bottom Line: We present here results limited to five university hospitals.Our results suggest that hospital registries are inaccurate for epidemiological studies unless patients are carefully re-evaluated.Smoking in patients with IPF was less common than in previous reports.

View Article: PubMed Central - PubMed

Affiliation: Division of Medicine, Pulmonary Diseases, Turku University Hospital, University of Turku, Turku, Finland. jakrja@utu.fi.

ABSTRACT

Background: The FinnishIPF registry is a prospective, longitudinal national registry study on the epidemiology of idiopathic pulmonary fibrosis (IPF). It was designed to describe the characteristics, management and prognosis of prevalent and incident IPF patients. The study was initiated in 2012.

Methods: We present here results limited to five university hospitals. Patients with IPF were screened from hospital registries using ICD-10 diagnosis codes J84.1 and J84.9. All patients who gave informed consent were included and evaluated using novel diagnostic criteria. Point prevalence on the 31(st) of December in 2012 was calculated using the reported population in each university hospital city as the denominator.

Results: Patients with ICD-10 codes J84.1 and J84.9 yielded a heterogeneous group - on the basis of patient records assessed by pulmonologists only 20-30 % of the cases were IPF. After clinical, radiological and histological re-evaluation 111 of 123 (90 %) of patients fulfilled the clinical criteria of IPF. The estimated prevalence of IPF was 8.6 cases/100 000. 60.4 % were men. Forty four percent of the patients were never-smokers. At diagnosis, the patients' mean age was 73.5 years and mean FVC was 80.4 % and DLCO 57.3 % of predicted.

Conclusions: Our results suggest that hospital registries are inaccurate for epidemiological studies unless patients are carefully re-evaluated. IPF is diagnosed in Finland at a stage when lung function is still quite well preserved. Smoking in patients with IPF was less common than in previous reports.

No MeSH data available.


Related in: MedlinePlus