Limits...
Screening Ultrasound in Women with Negative Mammography: Outcome Analysis.

Hwang JY, Han BK, Ko EY, Shin JH, Hahn SY, Nam MY - Yonsei Med. J. (2015)

Bottom Line: We analyzed the distribution of Breast Imaging Reporting and Data System (BI-RADS) category and the performance outcome through follow up.The recall rate (=BI-RADS category 3, 4, 5) was 5.8%.The sensitivity, specificity, and positive predictive value (PPV1, PPV2) were 88.9%, 94.6%, 8.0%, and 28.0%, respectively.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

ABSTRACT

Purpose: To show the results of an audit of screening breast ultrasound (US) in women with negative mammography in a single institution and to analyze US-detected cancers within a year and interval cancers.

Materials and methods: During the year of 2006, 1974 women with negative mammography were screened with US in our screening center, and 1727 among them had pathologic results or any follow up breast examinations more than a year. We analyzed the distribution of Breast Imaging Reporting and Data System (BI-RADS) category and the performance outcome through follow up.

Results: Among 1727 women (age, 30-76 years, median 49.5 years), 1349 women (78.1%) showed dense breasts on mammography, 762 (44.1%) had previous breast US, and 25 women (1.4%) had a personal history of breast cancers. Test negatives were 94.2% (1.627/1727) [BI-RADS category 1 in 885 (51.2%), 2 in 742 (43.0%)]. The recall rate (=BI-RADS category 3, 4, 5) was 5.8%. Eight cancers were additionally detected with US (yield, 4.6 per 1000). The sensitivity, specificity, and positive predictive value (PPV1, PPV2) were 88.9%, 94.6%, 8.0%, and 28.0%, respectively. Eight of nine true positive cancers were stage I or in-situ cancers. One interval cancer was stage I cancer from BI-RADS category 2.

Conclusion: Screening US detected 4.6 additional cancers among 1000. The recall rate was 5.8%, which is in lower bound of acceptable range of mammography (5-12%), according to American College of Radiology standard.

No MeSH data available.


Related in: MedlinePlus

Proportion of dense breasts according to the women's age.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4541666&req=5

Figure 3: Proportion of dense breasts according to the women's age.

Mentions: The median age of the 1727 women was 49.5 years (age range: 30-76 years). The majority of the women were in their forties (n=763, 44.2%) or in their fifties (n=693, 40.1%), and the rest were in their sixties (n=143, 8.3%), 30's (n=107, 6.2%), and seventies (n=21, 1.2%) (Fig. 2). Among them, 23 (1.1%) women had a family history of breast cancer and 29 (1.5%) had a previous operation for breast cancer. At least one previous breast US within the previous three years were available in 762 of the 1727 (44.1%) women. Of the total subjects, 1349 (78.1%) showed dense mammographic composition. Dense breasts appeared in 88.8% (95/107) of women under the age of 40 years, 91.9% (701/763) of women aged 40 to 49 years, 69.7% (483/693) of women aged 50 to 59 years, 46.9% (67/143) of women aged 60 to 69 years, and 14.3% (3/21) of women aged 70 and over (Fig. 3).


Screening Ultrasound in Women with Negative Mammography: Outcome Analysis.

Hwang JY, Han BK, Ko EY, Shin JH, Hahn SY, Nam MY - Yonsei Med. J. (2015)

Proportion of dense breasts according to the women's age.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4541666&req=5

Figure 3: Proportion of dense breasts according to the women's age.
Mentions: The median age of the 1727 women was 49.5 years (age range: 30-76 years). The majority of the women were in their forties (n=763, 44.2%) or in their fifties (n=693, 40.1%), and the rest were in their sixties (n=143, 8.3%), 30's (n=107, 6.2%), and seventies (n=21, 1.2%) (Fig. 2). Among them, 23 (1.1%) women had a family history of breast cancer and 29 (1.5%) had a previous operation for breast cancer. At least one previous breast US within the previous three years were available in 762 of the 1727 (44.1%) women. Of the total subjects, 1349 (78.1%) showed dense mammographic composition. Dense breasts appeared in 88.8% (95/107) of women under the age of 40 years, 91.9% (701/763) of women aged 40 to 49 years, 69.7% (483/693) of women aged 50 to 59 years, 46.9% (67/143) of women aged 60 to 69 years, and 14.3% (3/21) of women aged 70 and over (Fig. 3).

Bottom Line: We analyzed the distribution of Breast Imaging Reporting and Data System (BI-RADS) category and the performance outcome through follow up.The recall rate (=BI-RADS category 3, 4, 5) was 5.8%.The sensitivity, specificity, and positive predictive value (PPV1, PPV2) were 88.9%, 94.6%, 8.0%, and 28.0%, respectively.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

ABSTRACT

Purpose: To show the results of an audit of screening breast ultrasound (US) in women with negative mammography in a single institution and to analyze US-detected cancers within a year and interval cancers.

Materials and methods: During the year of 2006, 1974 women with negative mammography were screened with US in our screening center, and 1727 among them had pathologic results or any follow up breast examinations more than a year. We analyzed the distribution of Breast Imaging Reporting and Data System (BI-RADS) category and the performance outcome through follow up.

Results: Among 1727 women (age, 30-76 years, median 49.5 years), 1349 women (78.1%) showed dense breasts on mammography, 762 (44.1%) had previous breast US, and 25 women (1.4%) had a personal history of breast cancers. Test negatives were 94.2% (1.627/1727) [BI-RADS category 1 in 885 (51.2%), 2 in 742 (43.0%)]. The recall rate (=BI-RADS category 3, 4, 5) was 5.8%. Eight cancers were additionally detected with US (yield, 4.6 per 1000). The sensitivity, specificity, and positive predictive value (PPV1, PPV2) were 88.9%, 94.6%, 8.0%, and 28.0%, respectively. Eight of nine true positive cancers were stage I or in-situ cancers. One interval cancer was stage I cancer from BI-RADS category 2.

Conclusion: Screening US detected 4.6 additional cancers among 1000. The recall rate was 5.8%, which is in lower bound of acceptable range of mammography (5-12%), according to American College of Radiology standard.

No MeSH data available.


Related in: MedlinePlus