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Screening Ultrasound in Women with Negative Mammography: Outcome Analysis.

Hwang JY, Han BK, Ko EY, Shin JH, Hahn SY, Nam MY - Yonsei Med. J. (2015)

Bottom Line: We analyzed the distribution of Breast Imaging Reporting and Data System (BI-RADS) category and the performance outcome through follow up.The recall rate (=BI-RADS category 3, 4, 5) was 5.8%.The sensitivity, specificity, and positive predictive value (PPV1, PPV2) were 88.9%, 94.6%, 8.0%, and 28.0%, respectively.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

ABSTRACT

Purpose: To show the results of an audit of screening breast ultrasound (US) in women with negative mammography in a single institution and to analyze US-detected cancers within a year and interval cancers.

Materials and methods: During the year of 2006, 1974 women with negative mammography were screened with US in our screening center, and 1727 among them had pathologic results or any follow up breast examinations more than a year. We analyzed the distribution of Breast Imaging Reporting and Data System (BI-RADS) category and the performance outcome through follow up.

Results: Among 1727 women (age, 30-76 years, median 49.5 years), 1349 women (78.1%) showed dense breasts on mammography, 762 (44.1%) had previous breast US, and 25 women (1.4%) had a personal history of breast cancers. Test negatives were 94.2% (1.627/1727) [BI-RADS category 1 in 885 (51.2%), 2 in 742 (43.0%)]. The recall rate (=BI-RADS category 3, 4, 5) was 5.8%. Eight cancers were additionally detected with US (yield, 4.6 per 1000). The sensitivity, specificity, and positive predictive value (PPV1, PPV2) were 88.9%, 94.6%, 8.0%, and 28.0%, respectively. Eight of nine true positive cancers were stage I or in-situ cancers. One interval cancer was stage I cancer from BI-RADS category 2.

Conclusion: Screening US detected 4.6 additional cancers among 1000. The recall rate was 5.8%, which is in lower bound of acceptable range of mammography (5-12%), according to American College of Radiology standard.

No MeSH data available.


Related in: MedlinePlus

Study population. BI-RADS, Breast Imaging Reporting and Data System; US, ultrasound; FU, follow up.
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Figure 1: Study population. BI-RADS, Breast Imaging Reporting and Data System; US, ultrasound; FU, follow up.

Mentions: During the year of 2006, a total of 8320 asymptomatic women, aged at least 30 years, underwent mammograms for breast screening at our screening center. Women who complained of signs or symptoms of breast cancers were excluded. Among them, 520 (6.3%) had positive mammographic results, [Breast Imaging Reporting and Data System (BI-RADS) category 0, 3, 4, 5] and 18 women (0.22% of the total, 3.5% of positive mammograms) were diagnosed as breast cancers based on mammographic findings. Among the 7800 women with negative mammographic results (BI-RADS category 1, 2), 1974 (25.3%) underwent supplemental screening US. US was performed in women who requested them, regardless of their risk factors. Among the 1974 women with mammography plus US screening, 1727 (87.5%) had pathologic data or follow-up breast imaging (US and/or mammography) performed at least one year after the screening examination of this year until the year 2011 (Fig. 1).


Screening Ultrasound in Women with Negative Mammography: Outcome Analysis.

Hwang JY, Han BK, Ko EY, Shin JH, Hahn SY, Nam MY - Yonsei Med. J. (2015)

Study population. BI-RADS, Breast Imaging Reporting and Data System; US, ultrasound; FU, follow up.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4541666&req=5

Figure 1: Study population. BI-RADS, Breast Imaging Reporting and Data System; US, ultrasound; FU, follow up.
Mentions: During the year of 2006, a total of 8320 asymptomatic women, aged at least 30 years, underwent mammograms for breast screening at our screening center. Women who complained of signs or symptoms of breast cancers were excluded. Among them, 520 (6.3%) had positive mammographic results, [Breast Imaging Reporting and Data System (BI-RADS) category 0, 3, 4, 5] and 18 women (0.22% of the total, 3.5% of positive mammograms) were diagnosed as breast cancers based on mammographic findings. Among the 7800 women with negative mammographic results (BI-RADS category 1, 2), 1974 (25.3%) underwent supplemental screening US. US was performed in women who requested them, regardless of their risk factors. Among the 1974 women with mammography plus US screening, 1727 (87.5%) had pathologic data or follow-up breast imaging (US and/or mammography) performed at least one year after the screening examination of this year until the year 2011 (Fig. 1).

Bottom Line: We analyzed the distribution of Breast Imaging Reporting and Data System (BI-RADS) category and the performance outcome through follow up.The recall rate (=BI-RADS category 3, 4, 5) was 5.8%.The sensitivity, specificity, and positive predictive value (PPV1, PPV2) were 88.9%, 94.6%, 8.0%, and 28.0%, respectively.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

ABSTRACT

Purpose: To show the results of an audit of screening breast ultrasound (US) in women with negative mammography in a single institution and to analyze US-detected cancers within a year and interval cancers.

Materials and methods: During the year of 2006, 1974 women with negative mammography were screened with US in our screening center, and 1727 among them had pathologic results or any follow up breast examinations more than a year. We analyzed the distribution of Breast Imaging Reporting and Data System (BI-RADS) category and the performance outcome through follow up.

Results: Among 1727 women (age, 30-76 years, median 49.5 years), 1349 women (78.1%) showed dense breasts on mammography, 762 (44.1%) had previous breast US, and 25 women (1.4%) had a personal history of breast cancers. Test negatives were 94.2% (1.627/1727) [BI-RADS category 1 in 885 (51.2%), 2 in 742 (43.0%)]. The recall rate (=BI-RADS category 3, 4, 5) was 5.8%. Eight cancers were additionally detected with US (yield, 4.6 per 1000). The sensitivity, specificity, and positive predictive value (PPV1, PPV2) were 88.9%, 94.6%, 8.0%, and 28.0%, respectively. Eight of nine true positive cancers were stage I or in-situ cancers. One interval cancer was stage I cancer from BI-RADS category 2.

Conclusion: Screening US detected 4.6 additional cancers among 1000. The recall rate was 5.8%, which is in lower bound of acceptable range of mammography (5-12%), according to American College of Radiology standard.

No MeSH data available.


Related in: MedlinePlus