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IL-10 Polymorphisms and Tuberculosis Susceptibility: An Updated Meta-Analysis.

Ke Z, Yuan L, Ma J, Zhang X, Guo Y, Xiong H - Yonsei Med. J. (2015)

Bottom Line: The results indicated significant association of the allele model, heterozygous model and dominant model of IL-6 -174G/C polymorphism with decreased risk of TB.Moreover, significantly decreased risk of TB was associated with Asians for IL-6 -174C/G polymorphism in allele model, heterozygous model and dominant model.The results suggested that the IL-10 -1082G/A polymorphism is associated with increased TB risk in Europeans, while IL-10 -819C/T and IL-10 -592A/C polymorphisms in Asians.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacy, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei Province, P.R. China.

ABSTRACT

Purpose: The association of interleukin-10 (IL-10) polymorphisms (-1082G/A, -819C/T, -592A/C) and interleukin-6 (IL-6) poly-morphisms (-174G/C) with tuberculosis (TB) risk has been widely reported. However, the results are controversial. To clarify the role of these polymorphisms in TB, we performed a meta-analysis of all available and relevant published studies.

Materials and methods: Based on comprehensive searches of the PubMed, Medline, Embase, Web of Science, Elsevier Science Direct and Cochrane Library database, we identified outcome data from all articles estimating the association between IL-10 and IL-6 polymorphisms and TB risk.

Results: The results indicated significant association of the allele model, heterozygous model and dominant model of IL-6 -174G/C polymorphism with decreased risk of TB. In the stratified analysis by ethnicity, significantly increased risk was observed for IL-10 -1082G/A polymorphism in Europeans under recessive model, for IL-10 -819C/T polymorphism in Asians under heterozygous model and dominant model and IL-10 -592A/C polymorphism in Asians under Allele model, homozygous model and recessive model. Moreover, significantly decreased risk of TB was associated with Asians for IL-6 -174C/G polymorphism in allele model, heterozygous model and dominant model. We also performed the analyses by sample types in IL-10 -1082G/A polymorphism, and observed significantly increased TB risk in mixed group under homozygous model.

Conclusion: The results suggested that the IL-10 -1082G/A polymorphism is associated with increased TB risk in Europeans, while IL-10 -819C/T and IL-10 -592A/C polymorphisms in Asians. However, IL-6 -174G/C polymorphism might be a genetic risk factor that decreases TB susceptibility in Asians.

No MeSH data available.


Related in: MedlinePlus

Funnel plot for publication bias of the meta-analysis of tuberculosis risk and IL-10 polymorphisms in allele genetic model comparison. (A) IL-10 -1082G/A polymorphism. (B) IL-10 -819C/T polymorphism. (C) IL-10 -592A/C polymorphism. (D) IL-6 -174G/C polymorphism. IL-10, interleukin 10; IL-6, interleukin 6.
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Figure 4: Funnel plot for publication bias of the meta-analysis of tuberculosis risk and IL-10 polymorphisms in allele genetic model comparison. (A) IL-10 -1082G/A polymorphism. (B) IL-10 -819C/T polymorphism. (C) IL-10 -592A/C polymorphism. (D) IL-6 -174G/C polymorphism. IL-10, interleukin 10; IL-6, interleukin 6.

Mentions: Begg's funnel plot and Egger's test were performed to assess the publication bias of included studies. The shapes of the funnel plots did not reveal any evidence of obvious asymmetry in the all genetic models. In all genetic models, Egger's test also did not show any significant statistical evidence of publication bias, indicating low risk of publication bias in this meta-analysis (Fig. 4, Table 6).


IL-10 Polymorphisms and Tuberculosis Susceptibility: An Updated Meta-Analysis.

Ke Z, Yuan L, Ma J, Zhang X, Guo Y, Xiong H - Yonsei Med. J. (2015)

Funnel plot for publication bias of the meta-analysis of tuberculosis risk and IL-10 polymorphisms in allele genetic model comparison. (A) IL-10 -1082G/A polymorphism. (B) IL-10 -819C/T polymorphism. (C) IL-10 -592A/C polymorphism. (D) IL-6 -174G/C polymorphism. IL-10, interleukin 10; IL-6, interleukin 6.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4541657&req=5

Figure 4: Funnel plot for publication bias of the meta-analysis of tuberculosis risk and IL-10 polymorphisms in allele genetic model comparison. (A) IL-10 -1082G/A polymorphism. (B) IL-10 -819C/T polymorphism. (C) IL-10 -592A/C polymorphism. (D) IL-6 -174G/C polymorphism. IL-10, interleukin 10; IL-6, interleukin 6.
Mentions: Begg's funnel plot and Egger's test were performed to assess the publication bias of included studies. The shapes of the funnel plots did not reveal any evidence of obvious asymmetry in the all genetic models. In all genetic models, Egger's test also did not show any significant statistical evidence of publication bias, indicating low risk of publication bias in this meta-analysis (Fig. 4, Table 6).

Bottom Line: The results indicated significant association of the allele model, heterozygous model and dominant model of IL-6 -174G/C polymorphism with decreased risk of TB.Moreover, significantly decreased risk of TB was associated with Asians for IL-6 -174C/G polymorphism in allele model, heterozygous model and dominant model.The results suggested that the IL-10 -1082G/A polymorphism is associated with increased TB risk in Europeans, while IL-10 -819C/T and IL-10 -592A/C polymorphisms in Asians.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacy, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei Province, P.R. China.

ABSTRACT

Purpose: The association of interleukin-10 (IL-10) polymorphisms (-1082G/A, -819C/T, -592A/C) and interleukin-6 (IL-6) poly-morphisms (-174G/C) with tuberculosis (TB) risk has been widely reported. However, the results are controversial. To clarify the role of these polymorphisms in TB, we performed a meta-analysis of all available and relevant published studies.

Materials and methods: Based on comprehensive searches of the PubMed, Medline, Embase, Web of Science, Elsevier Science Direct and Cochrane Library database, we identified outcome data from all articles estimating the association between IL-10 and IL-6 polymorphisms and TB risk.

Results: The results indicated significant association of the allele model, heterozygous model and dominant model of IL-6 -174G/C polymorphism with decreased risk of TB. In the stratified analysis by ethnicity, significantly increased risk was observed for IL-10 -1082G/A polymorphism in Europeans under recessive model, for IL-10 -819C/T polymorphism in Asians under heterozygous model and dominant model and IL-10 -592A/C polymorphism in Asians under Allele model, homozygous model and recessive model. Moreover, significantly decreased risk of TB was associated with Asians for IL-6 -174C/G polymorphism in allele model, heterozygous model and dominant model. We also performed the analyses by sample types in IL-10 -1082G/A polymorphism, and observed significantly increased TB risk in mixed group under homozygous model.

Conclusion: The results suggested that the IL-10 -1082G/A polymorphism is associated with increased TB risk in Europeans, while IL-10 -819C/T and IL-10 -592A/C polymorphisms in Asians. However, IL-6 -174G/C polymorphism might be a genetic risk factor that decreases TB susceptibility in Asians.

No MeSH data available.


Related in: MedlinePlus