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IL-10 Polymorphisms and Tuberculosis Susceptibility: An Updated Meta-Analysis.

Ke Z, Yuan L, Ma J, Zhang X, Guo Y, Xiong H - Yonsei Med. J. (2015)

Bottom Line: The results indicated significant association of the allele model, heterozygous model and dominant model of IL-6 -174G/C polymorphism with decreased risk of TB.Moreover, significantly decreased risk of TB was associated with Asians for IL-6 -174C/G polymorphism in allele model, heterozygous model and dominant model.The results suggested that the IL-10 -1082G/A polymorphism is associated with increased TB risk in Europeans, while IL-10 -819C/T and IL-10 -592A/C polymorphisms in Asians.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacy, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei Province, P.R. China.

ABSTRACT

Purpose: The association of interleukin-10 (IL-10) polymorphisms (-1082G/A, -819C/T, -592A/C) and interleukin-6 (IL-6) poly-morphisms (-174G/C) with tuberculosis (TB) risk has been widely reported. However, the results are controversial. To clarify the role of these polymorphisms in TB, we performed a meta-analysis of all available and relevant published studies.

Materials and methods: Based on comprehensive searches of the PubMed, Medline, Embase, Web of Science, Elsevier Science Direct and Cochrane Library database, we identified outcome data from all articles estimating the association between IL-10 and IL-6 polymorphisms and TB risk.

Results: The results indicated significant association of the allele model, heterozygous model and dominant model of IL-6 -174G/C polymorphism with decreased risk of TB. In the stratified analysis by ethnicity, significantly increased risk was observed for IL-10 -1082G/A polymorphism in Europeans under recessive model, for IL-10 -819C/T polymorphism in Asians under heterozygous model and dominant model and IL-10 -592A/C polymorphism in Asians under Allele model, homozygous model and recessive model. Moreover, significantly decreased risk of TB was associated with Asians for IL-6 -174C/G polymorphism in allele model, heterozygous model and dominant model. We also performed the analyses by sample types in IL-10 -1082G/A polymorphism, and observed significantly increased TB risk in mixed group under homozygous model.

Conclusion: The results suggested that the IL-10 -1082G/A polymorphism is associated with increased TB risk in Europeans, while IL-10 -819C/T and IL-10 -592A/C polymorphisms in Asians. However, IL-6 -174G/C polymorphism might be a genetic risk factor that decreases TB susceptibility in Asians.

No MeSH data available.


Related in: MedlinePlus

Galbraith plot of IL-10 promoter polymorphism and TB risk. (A-E) The five studies1820223133 in G vs. A, three studies202231 in GG vs. AA, seven studies13182022313337 in AG vs. AA, six studies131820223133 in GG+AG vs. AA, and five studies2022273537 in GG vs. AG+AA were outliers for -1082G/A. (F and G) The one study38 in TC vs. CC and one study38 in TT+TC vs. CC for -819C/T. (H-K) The three studies262838 in A vs. C, one study38 in AA vs. CC, one study38 in AA+AC vs. CC, and two studies1738 in AA vs. AC+CC for -592A/C. TB, tuberculosis; IL-10, interleukin 10.
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Figure 3: Galbraith plot of IL-10 promoter polymorphism and TB risk. (A-E) The five studies1820223133 in G vs. A, three studies202231 in GG vs. AA, seven studies13182022313337 in AG vs. AA, six studies131820223133 in GG+AG vs. AA, and five studies2022273537 in GG vs. AG+AA were outliers for -1082G/A. (F and G) The one study38 in TC vs. CC and one study38 in TT+TC vs. CC for -819C/T. (H-K) The three studies262838 in A vs. C, one study38 in AA vs. CC, one study38 in AA+AC vs. CC, and two studies1738 in AA vs. AC+CC for -592A/C. TB, tuberculosis; IL-10, interleukin 10.

Mentions: There were statistically significant heterogeneity in all genetic models for IL-10 -1082G/A polymorphism, heterozygous model and dominant model for IL-10 -819C/T polymorphism, and all genetic models except for heterozygous model for IL-10 -592A/C (Table 3). To elucidate the heterogeneity, Galbraith plots were performed in these genetic models. When the studies which were outliers in some genetic models were excluded respectively, all I2 values were less than 50%, and Pheterogeneity were greater than 0.1 (Fig. 3, Table 4). The significance of pooled OR in all genetic models was not influenced after excluding the studies. By meta-regression analysis, the heterogeneity sources were attributable to the sample types, ethnicity, control source, and the genotyping method. Ethnicity and sample types might be predominant sources of heterogeneity in IL-10 -1082G/A polymorphism, and ethnicity and control source in both IL-10 -819C/T and IL-10 -592A/C polymorphisms (Table 5).


IL-10 Polymorphisms and Tuberculosis Susceptibility: An Updated Meta-Analysis.

Ke Z, Yuan L, Ma J, Zhang X, Guo Y, Xiong H - Yonsei Med. J. (2015)

Galbraith plot of IL-10 promoter polymorphism and TB risk. (A-E) The five studies1820223133 in G vs. A, three studies202231 in GG vs. AA, seven studies13182022313337 in AG vs. AA, six studies131820223133 in GG+AG vs. AA, and five studies2022273537 in GG vs. AG+AA were outliers for -1082G/A. (F and G) The one study38 in TC vs. CC and one study38 in TT+TC vs. CC for -819C/T. (H-K) The three studies262838 in A vs. C, one study38 in AA vs. CC, one study38 in AA+AC vs. CC, and two studies1738 in AA vs. AC+CC for -592A/C. TB, tuberculosis; IL-10, interleukin 10.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4541657&req=5

Figure 3: Galbraith plot of IL-10 promoter polymorphism and TB risk. (A-E) The five studies1820223133 in G vs. A, three studies202231 in GG vs. AA, seven studies13182022313337 in AG vs. AA, six studies131820223133 in GG+AG vs. AA, and five studies2022273537 in GG vs. AG+AA were outliers for -1082G/A. (F and G) The one study38 in TC vs. CC and one study38 in TT+TC vs. CC for -819C/T. (H-K) The three studies262838 in A vs. C, one study38 in AA vs. CC, one study38 in AA+AC vs. CC, and two studies1738 in AA vs. AC+CC for -592A/C. TB, tuberculosis; IL-10, interleukin 10.
Mentions: There were statistically significant heterogeneity in all genetic models for IL-10 -1082G/A polymorphism, heterozygous model and dominant model for IL-10 -819C/T polymorphism, and all genetic models except for heterozygous model for IL-10 -592A/C (Table 3). To elucidate the heterogeneity, Galbraith plots were performed in these genetic models. When the studies which were outliers in some genetic models were excluded respectively, all I2 values were less than 50%, and Pheterogeneity were greater than 0.1 (Fig. 3, Table 4). The significance of pooled OR in all genetic models was not influenced after excluding the studies. By meta-regression analysis, the heterogeneity sources were attributable to the sample types, ethnicity, control source, and the genotyping method. Ethnicity and sample types might be predominant sources of heterogeneity in IL-10 -1082G/A polymorphism, and ethnicity and control source in both IL-10 -819C/T and IL-10 -592A/C polymorphisms (Table 5).

Bottom Line: The results indicated significant association of the allele model, heterozygous model and dominant model of IL-6 -174G/C polymorphism with decreased risk of TB.Moreover, significantly decreased risk of TB was associated with Asians for IL-6 -174C/G polymorphism in allele model, heterozygous model and dominant model.The results suggested that the IL-10 -1082G/A polymorphism is associated with increased TB risk in Europeans, while IL-10 -819C/T and IL-10 -592A/C polymorphisms in Asians.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacy, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei Province, P.R. China.

ABSTRACT

Purpose: The association of interleukin-10 (IL-10) polymorphisms (-1082G/A, -819C/T, -592A/C) and interleukin-6 (IL-6) poly-morphisms (-174G/C) with tuberculosis (TB) risk has been widely reported. However, the results are controversial. To clarify the role of these polymorphisms in TB, we performed a meta-analysis of all available and relevant published studies.

Materials and methods: Based on comprehensive searches of the PubMed, Medline, Embase, Web of Science, Elsevier Science Direct and Cochrane Library database, we identified outcome data from all articles estimating the association between IL-10 and IL-6 polymorphisms and TB risk.

Results: The results indicated significant association of the allele model, heterozygous model and dominant model of IL-6 -174G/C polymorphism with decreased risk of TB. In the stratified analysis by ethnicity, significantly increased risk was observed for IL-10 -1082G/A polymorphism in Europeans under recessive model, for IL-10 -819C/T polymorphism in Asians under heterozygous model and dominant model and IL-10 -592A/C polymorphism in Asians under Allele model, homozygous model and recessive model. Moreover, significantly decreased risk of TB was associated with Asians for IL-6 -174C/G polymorphism in allele model, heterozygous model and dominant model. We also performed the analyses by sample types in IL-10 -1082G/A polymorphism, and observed significantly increased TB risk in mixed group under homozygous model.

Conclusion: The results suggested that the IL-10 -1082G/A polymorphism is associated with increased TB risk in Europeans, while IL-10 -819C/T and IL-10 -592A/C polymorphisms in Asians. However, IL-6 -174G/C polymorphism might be a genetic risk factor that decreases TB susceptibility in Asians.

No MeSH data available.


Related in: MedlinePlus