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IL-10 Polymorphisms and Tuberculosis Susceptibility: An Updated Meta-Analysis.

Ke Z, Yuan L, Ma J, Zhang X, Guo Y, Xiong H - Yonsei Med. J. (2015)

Bottom Line: The results indicated significant association of the allele model, heterozygous model and dominant model of IL-6 -174G/C polymorphism with decreased risk of TB.Moreover, significantly decreased risk of TB was associated with Asians for IL-6 -174C/G polymorphism in allele model, heterozygous model and dominant model.The results suggested that the IL-10 -1082G/A polymorphism is associated with increased TB risk in Europeans, while IL-10 -819C/T and IL-10 -592A/C polymorphisms in Asians.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacy, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei Province, P.R. China.

ABSTRACT

Purpose: The association of interleukin-10 (IL-10) polymorphisms (-1082G/A, -819C/T, -592A/C) and interleukin-6 (IL-6) poly-morphisms (-174G/C) with tuberculosis (TB) risk has been widely reported. However, the results are controversial. To clarify the role of these polymorphisms in TB, we performed a meta-analysis of all available and relevant published studies.

Materials and methods: Based on comprehensive searches of the PubMed, Medline, Embase, Web of Science, Elsevier Science Direct and Cochrane Library database, we identified outcome data from all articles estimating the association between IL-10 and IL-6 polymorphisms and TB risk.

Results: The results indicated significant association of the allele model, heterozygous model and dominant model of IL-6 -174G/C polymorphism with decreased risk of TB. In the stratified analysis by ethnicity, significantly increased risk was observed for IL-10 -1082G/A polymorphism in Europeans under recessive model, for IL-10 -819C/T polymorphism in Asians under heterozygous model and dominant model and IL-10 -592A/C polymorphism in Asians under Allele model, homozygous model and recessive model. Moreover, significantly decreased risk of TB was associated with Asians for IL-6 -174C/G polymorphism in allele model, heterozygous model and dominant model. We also performed the analyses by sample types in IL-10 -1082G/A polymorphism, and observed significantly increased TB risk in mixed group under homozygous model.

Conclusion: The results suggested that the IL-10 -1082G/A polymorphism is associated with increased TB risk in Europeans, while IL-10 -819C/T and IL-10 -592A/C polymorphisms in Asians. However, IL-6 -174G/C polymorphism might be a genetic risk factor that decreases TB susceptibility in Asians.

No MeSH data available.


Related in: MedlinePlus

Forest plot of the overall risk of TB associated with the IL-10 -1082G/A and -819C/T polymorphism in all genetic models. Bars represent 95% CI and boxes represent OR values. The size of each box indicates the weight of the study in the pooled results. (F-J) T allele vs. C allele, TT vs. CC, TC vs. CC, TT+TC vs. CC, TT vs. TC+CC for -819C/T. TB, tuberculosis; IL-10, interleukin 10; CI, confidence interval; OR, odds ratio.
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Figure 2: Forest plot of the overall risk of TB associated with the IL-10 -1082G/A and -819C/T polymorphism in all genetic models. Bars represent 95% CI and boxes represent OR values. The size of each box indicates the weight of the study in the pooled results. (F-J) T allele vs. C allele, TT vs. CC, TC vs. CC, TT+TC vs. CC, TT vs. TC+CC for -819C/T. TB, tuberculosis; IL-10, interleukin 10; CI, confidence interval; OR, odds ratio.

Mentions: In all, twenty-six studies consisted of 5949 cases and 6948 controls, and assessed the potential influence of the IL-10 -1082G/A polymorphism with TB susceptibility. Random effects models were used to calculate the pooled OR in all genetic models. Overall, the combined results showed no significant association in all genetic models (Fig. 2A-E). In the stratified analysis by ethnicity, IL-10 -1082G/A polymorphism was associated with a significantly increased risk of TB in European group under recessive model (GG vs. AG+AA: OR=1.69, 95% CI=1.19-2.39). However, no significant association was found in American, Asian and African populations in all tested models. On subgroup analysis by sample types, significantly increased TB risk was observed under homozygous model (GG vs. AA: OR= 2.00, 95% CI=1.16-3.45) in PTB and extra-pulmonary tuberculosis (EPTB) mixed group. The results are shown in Table 3.


IL-10 Polymorphisms and Tuberculosis Susceptibility: An Updated Meta-Analysis.

Ke Z, Yuan L, Ma J, Zhang X, Guo Y, Xiong H - Yonsei Med. J. (2015)

Forest plot of the overall risk of TB associated with the IL-10 -1082G/A and -819C/T polymorphism in all genetic models. Bars represent 95% CI and boxes represent OR values. The size of each box indicates the weight of the study in the pooled results. (F-J) T allele vs. C allele, TT vs. CC, TC vs. CC, TT+TC vs. CC, TT vs. TC+CC for -819C/T. TB, tuberculosis; IL-10, interleukin 10; CI, confidence interval; OR, odds ratio.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4541657&req=5

Figure 2: Forest plot of the overall risk of TB associated with the IL-10 -1082G/A and -819C/T polymorphism in all genetic models. Bars represent 95% CI and boxes represent OR values. The size of each box indicates the weight of the study in the pooled results. (F-J) T allele vs. C allele, TT vs. CC, TC vs. CC, TT+TC vs. CC, TT vs. TC+CC for -819C/T. TB, tuberculosis; IL-10, interleukin 10; CI, confidence interval; OR, odds ratio.
Mentions: In all, twenty-six studies consisted of 5949 cases and 6948 controls, and assessed the potential influence of the IL-10 -1082G/A polymorphism with TB susceptibility. Random effects models were used to calculate the pooled OR in all genetic models. Overall, the combined results showed no significant association in all genetic models (Fig. 2A-E). In the stratified analysis by ethnicity, IL-10 -1082G/A polymorphism was associated with a significantly increased risk of TB in European group under recessive model (GG vs. AG+AA: OR=1.69, 95% CI=1.19-2.39). However, no significant association was found in American, Asian and African populations in all tested models. On subgroup analysis by sample types, significantly increased TB risk was observed under homozygous model (GG vs. AA: OR= 2.00, 95% CI=1.16-3.45) in PTB and extra-pulmonary tuberculosis (EPTB) mixed group. The results are shown in Table 3.

Bottom Line: The results indicated significant association of the allele model, heterozygous model and dominant model of IL-6 -174G/C polymorphism with decreased risk of TB.Moreover, significantly decreased risk of TB was associated with Asians for IL-6 -174C/G polymorphism in allele model, heterozygous model and dominant model.The results suggested that the IL-10 -1082G/A polymorphism is associated with increased TB risk in Europeans, while IL-10 -819C/T and IL-10 -592A/C polymorphisms in Asians.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacy, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei Province, P.R. China.

ABSTRACT

Purpose: The association of interleukin-10 (IL-10) polymorphisms (-1082G/A, -819C/T, -592A/C) and interleukin-6 (IL-6) poly-morphisms (-174G/C) with tuberculosis (TB) risk has been widely reported. However, the results are controversial. To clarify the role of these polymorphisms in TB, we performed a meta-analysis of all available and relevant published studies.

Materials and methods: Based on comprehensive searches of the PubMed, Medline, Embase, Web of Science, Elsevier Science Direct and Cochrane Library database, we identified outcome data from all articles estimating the association between IL-10 and IL-6 polymorphisms and TB risk.

Results: The results indicated significant association of the allele model, heterozygous model and dominant model of IL-6 -174G/C polymorphism with decreased risk of TB. In the stratified analysis by ethnicity, significantly increased risk was observed for IL-10 -1082G/A polymorphism in Europeans under recessive model, for IL-10 -819C/T polymorphism in Asians under heterozygous model and dominant model and IL-10 -592A/C polymorphism in Asians under Allele model, homozygous model and recessive model. Moreover, significantly decreased risk of TB was associated with Asians for IL-6 -174C/G polymorphism in allele model, heterozygous model and dominant model. We also performed the analyses by sample types in IL-10 -1082G/A polymorphism, and observed significantly increased TB risk in mixed group under homozygous model.

Conclusion: The results suggested that the IL-10 -1082G/A polymorphism is associated with increased TB risk in Europeans, while IL-10 -819C/T and IL-10 -592A/C polymorphisms in Asians. However, IL-6 -174G/C polymorphism might be a genetic risk factor that decreases TB susceptibility in Asians.

No MeSH data available.


Related in: MedlinePlus