Limits...
IL-10 Polymorphisms and Tuberculosis Susceptibility: An Updated Meta-Analysis.

Ke Z, Yuan L, Ma J, Zhang X, Guo Y, Xiong H - Yonsei Med. J. (2015)

Bottom Line: The results indicated significant association of the allele model, heterozygous model and dominant model of IL-6 -174G/C polymorphism with decreased risk of TB.Moreover, significantly decreased risk of TB was associated with Asians for IL-6 -174C/G polymorphism in allele model, heterozygous model and dominant model.The results suggested that the IL-10 -1082G/A polymorphism is associated with increased TB risk in Europeans, while IL-10 -819C/T and IL-10 -592A/C polymorphisms in Asians.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacy, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei Province, P.R. China.

ABSTRACT

Purpose: The association of interleukin-10 (IL-10) polymorphisms (-1082G/A, -819C/T, -592A/C) and interleukin-6 (IL-6) poly-morphisms (-174G/C) with tuberculosis (TB) risk has been widely reported. However, the results are controversial. To clarify the role of these polymorphisms in TB, we performed a meta-analysis of all available and relevant published studies.

Materials and methods: Based on comprehensive searches of the PubMed, Medline, Embase, Web of Science, Elsevier Science Direct and Cochrane Library database, we identified outcome data from all articles estimating the association between IL-10 and IL-6 polymorphisms and TB risk.

Results: The results indicated significant association of the allele model, heterozygous model and dominant model of IL-6 -174G/C polymorphism with decreased risk of TB. In the stratified analysis by ethnicity, significantly increased risk was observed for IL-10 -1082G/A polymorphism in Europeans under recessive model, for IL-10 -819C/T polymorphism in Asians under heterozygous model and dominant model and IL-10 -592A/C polymorphism in Asians under Allele model, homozygous model and recessive model. Moreover, significantly decreased risk of TB was associated with Asians for IL-6 -174C/G polymorphism in allele model, heterozygous model and dominant model. We also performed the analyses by sample types in IL-10 -1082G/A polymorphism, and observed significantly increased TB risk in mixed group under homozygous model.

Conclusion: The results suggested that the IL-10 -1082G/A polymorphism is associated with increased TB risk in Europeans, while IL-10 -819C/T and IL-10 -592A/C polymorphisms in Asians. However, IL-6 -174G/C polymorphism might be a genetic risk factor that decreases TB susceptibility in Asians.

No MeSH data available.


Related in: MedlinePlus

Flow diagram for study selection.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4541657&req=5

Figure 1: Flow diagram for study selection.

Mentions: The flow chart that displays the study selection process is shown in Fig. 1. The search of the selected databases retrieved 30 potentially relevant articles, including 7800 cases and 8793 controls, according to inclusion and exclusion criteria. There are 26 case-control studies concerning IL-10 -1082G/A polymorphism,610111213141516171819202122232425262729303132333435 15 case-control studies for IL-10 -819C/T polymorphism,61014161720212224252829303236 16 case-control studies for IL-10 -592A/C polymorphism,6101415161720212425262930323336 and 7 case-control studies about IL-6 -174G/C polymorphism. 6161721253738 Among the 30 eligible studies, 14 of them were of Asians,611151819212223283031353738 6 studies were of Europeans,121316202534 6 studies were of Africans,101424272936 and 4 studies were of Americans.17263233 The NOS scores ranged from 7 to 9, indicating that the methodological quality was generally good. The detailed characteristics of the eligible studies included in this meta-analysis are shown in Table 1, and the genotype and allele distributions of all four polymorphisms are shown in Table 2. The genotype distributions among the controls of all studies were consistent with the HWE except for eight studies for the IL-10 -1082G/A,611132325272934 one study for the IL-10 -819C/T,36 three studies for the IL-10 -592A/C,143336 and two studies for the IL-6 -174G/C (Table 1).616


IL-10 Polymorphisms and Tuberculosis Susceptibility: An Updated Meta-Analysis.

Ke Z, Yuan L, Ma J, Zhang X, Guo Y, Xiong H - Yonsei Med. J. (2015)

Flow diagram for study selection.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4541657&req=5

Figure 1: Flow diagram for study selection.
Mentions: The flow chart that displays the study selection process is shown in Fig. 1. The search of the selected databases retrieved 30 potentially relevant articles, including 7800 cases and 8793 controls, according to inclusion and exclusion criteria. There are 26 case-control studies concerning IL-10 -1082G/A polymorphism,610111213141516171819202122232425262729303132333435 15 case-control studies for IL-10 -819C/T polymorphism,61014161720212224252829303236 16 case-control studies for IL-10 -592A/C polymorphism,6101415161720212425262930323336 and 7 case-control studies about IL-6 -174G/C polymorphism. 6161721253738 Among the 30 eligible studies, 14 of them were of Asians,611151819212223283031353738 6 studies were of Europeans,121316202534 6 studies were of Africans,101424272936 and 4 studies were of Americans.17263233 The NOS scores ranged from 7 to 9, indicating that the methodological quality was generally good. The detailed characteristics of the eligible studies included in this meta-analysis are shown in Table 1, and the genotype and allele distributions of all four polymorphisms are shown in Table 2. The genotype distributions among the controls of all studies were consistent with the HWE except for eight studies for the IL-10 -1082G/A,611132325272934 one study for the IL-10 -819C/T,36 three studies for the IL-10 -592A/C,143336 and two studies for the IL-6 -174G/C (Table 1).616

Bottom Line: The results indicated significant association of the allele model, heterozygous model and dominant model of IL-6 -174G/C polymorphism with decreased risk of TB.Moreover, significantly decreased risk of TB was associated with Asians for IL-6 -174C/G polymorphism in allele model, heterozygous model and dominant model.The results suggested that the IL-10 -1082G/A polymorphism is associated with increased TB risk in Europeans, while IL-10 -819C/T and IL-10 -592A/C polymorphisms in Asians.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacy, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei Province, P.R. China.

ABSTRACT

Purpose: The association of interleukin-10 (IL-10) polymorphisms (-1082G/A, -819C/T, -592A/C) and interleukin-6 (IL-6) poly-morphisms (-174G/C) with tuberculosis (TB) risk has been widely reported. However, the results are controversial. To clarify the role of these polymorphisms in TB, we performed a meta-analysis of all available and relevant published studies.

Materials and methods: Based on comprehensive searches of the PubMed, Medline, Embase, Web of Science, Elsevier Science Direct and Cochrane Library database, we identified outcome data from all articles estimating the association between IL-10 and IL-6 polymorphisms and TB risk.

Results: The results indicated significant association of the allele model, heterozygous model and dominant model of IL-6 -174G/C polymorphism with decreased risk of TB. In the stratified analysis by ethnicity, significantly increased risk was observed for IL-10 -1082G/A polymorphism in Europeans under recessive model, for IL-10 -819C/T polymorphism in Asians under heterozygous model and dominant model and IL-10 -592A/C polymorphism in Asians under Allele model, homozygous model and recessive model. Moreover, significantly decreased risk of TB was associated with Asians for IL-6 -174C/G polymorphism in allele model, heterozygous model and dominant model. We also performed the analyses by sample types in IL-10 -1082G/A polymorphism, and observed significantly increased TB risk in mixed group under homozygous model.

Conclusion: The results suggested that the IL-10 -1082G/A polymorphism is associated with increased TB risk in Europeans, while IL-10 -819C/T and IL-10 -592A/C polymorphisms in Asians. However, IL-6 -174G/C polymorphism might be a genetic risk factor that decreases TB susceptibility in Asians.

No MeSH data available.


Related in: MedlinePlus