Limits...
Clinical Features of Obstructive Sleep Apnea That Determine Its High Prevalence in Resistant Hypertension.

Min HJ, Cho YJ, Kim CH, Kim da H, Kim HY, Choi JI, Lee JG, Park S, Cho HJ - Yonsei Med. J. (2015)

Bottom Line: Therefore, we aimed to determine the clinical, laboratory, and polysomnographic features of resistant HTN that are significantly associated with OSA.The risk factors for the occurrence of OSA in controlled and resistant hypertensive patients were compared, and independent risk factors that are associated with OSA were analyzed.Age, body mass index, neck circumference, waist circumference, and hip circumference were significantly higher in OSA.

View Article: PubMed Central - PubMed

Affiliation: Department of Otorhinolaryngology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

ABSTRACT

Purpose: Resistant hypertension (HTN) occurs in 15-20% of treated hypertensive patients, and 70-80% of resistant hypertensive patients have obstructive sleep apnea (OSA). The characteristics of resistant HTN that predispose patients to OSA have not been reported. Therefore, we aimed to determine the clinical, laboratory, and polysomnographic features of resistant HTN that are significantly associated with OSA.

Materials and methods: Hypertensive patients (n=475) who underwent portable polysomnography were enrolled. The patients were categorized into controlled (n=410) and resistant HTN (n=65) groups. The risk factors for the occurrence of OSA in controlled and resistant hypertensive patients were compared, and independent risk factors that are associated with OSA were analyzed.

Results: Out of 475 patients, 359 (75.6%) were diagnosed with OSA. The prevalence of OSA in resistant HTN was 87.7%, which was significantly higher than that in controlled HTN (73.7%). Age, body mass index, neck circumference, waist circumference, and hip circumference were significantly higher in OSA. However, stepwise multivariate analyses revealed that resistant HTN was not an independent risk factor of OSA.

Conclusion: The higher prevalence and severity of OSA in resistant HTN may be due to the association of risk factors that are common to both conditions.

No MeSH data available.


Related in: MedlinePlus

Flowchart of patients. Hypertensive patients were asked to perform the sleep study (including polysomnography, sleep questionnaires, laboratory tests, and anthropometric measurements), and 475 patients with complete data were enrolled in this retrospective study.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4541655&req=5

Figure 1: Flowchart of patients. Hypertensive patients were asked to perform the sleep study (including polysomnography, sleep questionnaires, laboratory tests, and anthropometric measurements), and 475 patients with complete data were enrolled in this retrospective study.

Mentions: This was a retrospective analysis of the sleep apnea registry of the Cardiology Department at Yonsei University. During a 3-year period, 948 hypertensive patients underwent PSG for the evaluation of secondary HTN and/or OSA-related symptoms. Among these subjects, 364 patients were excluded due to incomplete medical records, and 109 patients were excluded due to missing values in anthropometric measurements, laboratory tests, PSG data, or sleep questionnaires. Finally, 475 patients with complete data were enrolled in the study for analysis (Fig. 1).


Clinical Features of Obstructive Sleep Apnea That Determine Its High Prevalence in Resistant Hypertension.

Min HJ, Cho YJ, Kim CH, Kim da H, Kim HY, Choi JI, Lee JG, Park S, Cho HJ - Yonsei Med. J. (2015)

Flowchart of patients. Hypertensive patients were asked to perform the sleep study (including polysomnography, sleep questionnaires, laboratory tests, and anthropometric measurements), and 475 patients with complete data were enrolled in this retrospective study.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4541655&req=5

Figure 1: Flowchart of patients. Hypertensive patients were asked to perform the sleep study (including polysomnography, sleep questionnaires, laboratory tests, and anthropometric measurements), and 475 patients with complete data were enrolled in this retrospective study.
Mentions: This was a retrospective analysis of the sleep apnea registry of the Cardiology Department at Yonsei University. During a 3-year period, 948 hypertensive patients underwent PSG for the evaluation of secondary HTN and/or OSA-related symptoms. Among these subjects, 364 patients were excluded due to incomplete medical records, and 109 patients were excluded due to missing values in anthropometric measurements, laboratory tests, PSG data, or sleep questionnaires. Finally, 475 patients with complete data were enrolled in the study for analysis (Fig. 1).

Bottom Line: Therefore, we aimed to determine the clinical, laboratory, and polysomnographic features of resistant HTN that are significantly associated with OSA.The risk factors for the occurrence of OSA in controlled and resistant hypertensive patients were compared, and independent risk factors that are associated with OSA were analyzed.Age, body mass index, neck circumference, waist circumference, and hip circumference were significantly higher in OSA.

View Article: PubMed Central - PubMed

Affiliation: Department of Otorhinolaryngology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

ABSTRACT

Purpose: Resistant hypertension (HTN) occurs in 15-20% of treated hypertensive patients, and 70-80% of resistant hypertensive patients have obstructive sleep apnea (OSA). The characteristics of resistant HTN that predispose patients to OSA have not been reported. Therefore, we aimed to determine the clinical, laboratory, and polysomnographic features of resistant HTN that are significantly associated with OSA.

Materials and methods: Hypertensive patients (n=475) who underwent portable polysomnography were enrolled. The patients were categorized into controlled (n=410) and resistant HTN (n=65) groups. The risk factors for the occurrence of OSA in controlled and resistant hypertensive patients were compared, and independent risk factors that are associated with OSA were analyzed.

Results: Out of 475 patients, 359 (75.6%) were diagnosed with OSA. The prevalence of OSA in resistant HTN was 87.7%, which was significantly higher than that in controlled HTN (73.7%). Age, body mass index, neck circumference, waist circumference, and hip circumference were significantly higher in OSA. However, stepwise multivariate analyses revealed that resistant HTN was not an independent risk factor of OSA.

Conclusion: The higher prevalence and severity of OSA in resistant HTN may be due to the association of risk factors that are common to both conditions.

No MeSH data available.


Related in: MedlinePlus