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eNOS3 Genetic Polymorphism Is Related to Post-Ablation Early Recurrence of Atrial Fibrillation.

Shim J, Park JH, Lee JY, Uhm JS, Joung B, Lee MH, Ellinor PT, Pak HN - Yonsei Med. J. (2015)

Bottom Line: The rs1799983 variant was associated with higher risk of ERAF (OR 1.71, 95% CI 1.06-2.79, p=0.028), but not with CR.ERAF occurred earlier (11±16 days) in variant group than those without variant allele (20±25 days, p=0.016).The rs1799983 variant of the eNOS3 gene was associated with ERAF, but not with CR, after RFCA. eNOS3 gene variants may have a potential role for stratification of post-ablation management.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Korea University Anam Hospital, Seoul, Korea.

ABSTRACT

Purpose: Previous studies have demonstrated an association between eNOS polymorphisms and atrial fibrillation (AF). We sought to determine whether eNOS polymorphisms are associated with AF recurrence after a radiofrequency catheter ablation (RFCA).

Materials and methods: A total of 500 consecutive patients (56±11 years, 77% male) with paroxysmal (68%) or persistent (32%) AF who underwent RFCA and 500 age, gender-matched controls were genotyped for the eNOS3 single nucleotide polymorphism (rs1799983). AF recurrence was monitored according to 2012 ACC/AHA/ESC guidelines.

Results: The frequencies of the rs1799983 variant alleles (T) in the case and control group were not significantly different (OR 1.05, 95% CI 0.75-1.46, p=0.798). AF patients with rs1799983 variants were more likely to have coronary artery disease or stroke than those without genetic variant at this gene (31.0% vs. 17.3%, p=0.004). During mean 17 months follow-up, early recurrence of AF (ERAF; within 3 months) and clinical recurrence (CR) of AF were 31.8% and 24.8%, respectively. The rs1799983 variant was associated with higher risk of ERAF (OR 1.71, 95% CI 1.06-2.79, p=0.028), but not with CR. ERAF occurred earlier (11±16 days) in variant group than those without variant allele (20±25 days, p=0.016). A multiple logistic regression analysis showed that presence of the rs1799983 variant (OR 1.75, 95% CI 1.07-2.86, p=0.026) and persistent AF were independent predictors for ERAF after AF ablation.

Conclusion: The rs1799983 variant of the eNOS3 gene was associated with ERAF, but not with CR, after RFCA. eNOS3 gene variants may have a potential role for stratification of post-ablation management.

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Related in: MedlinePlus

Kaplan-Meier curves of AF free survival between patients with and without the rs1799983 variant within 3 months after RFCA of AF. AF, atrial fibrillation; RFCA, radiofrequency catheter ablation.
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Figure 1: Kaplan-Meier curves of AF free survival between patients with and without the rs1799983 variant within 3 months after RFCA of AF. AF, atrial fibrillation; RFCA, radiofrequency catheter ablation.

Mentions: Table 3 summarizes the differences between AF patients with rs1799983 variants and those without variants. There were no significant differences in general clinical features and the degree of LA electro-anatomical remodeling between patients with and without the rs1799983 variant (T). In addition, serum hsCRP levels were not significantly higher in patients with the rs1799983 variant. Interestingly, the frequency of associated stroke/transient ischemic attack and coronary artery disease was significantly higher in patients with the rs1799983 variant (p=0.004). Statin utilization was also significantly higher in patients with the rs1799983 variant (p=0.010). ERAF (within 3 months post-RFCA) was observed in 31.8%, whereas clinical recurrence of AF (after 3 months post-RFCA) occurred in 24.8% of the patients during mean follow-up of 17±8 months. The clinical recurrence rate after 3 month post-RFCA was not different in patients with rs1799983 variant and in those without (p=0.907). However, ERAF was more frequent in patients with the variant allele of the rs1799983 than in those without (42.2% vs. 29.8%, p=0.027). In addition, ERAF occurred significantly earlier in the carriers of the variant allele (mean early recurrence days, 11±16 days vs. 20±25 days, p=0.016) (Fig. 1).


eNOS3 Genetic Polymorphism Is Related to Post-Ablation Early Recurrence of Atrial Fibrillation.

Shim J, Park JH, Lee JY, Uhm JS, Joung B, Lee MH, Ellinor PT, Pak HN - Yonsei Med. J. (2015)

Kaplan-Meier curves of AF free survival between patients with and without the rs1799983 variant within 3 months after RFCA of AF. AF, atrial fibrillation; RFCA, radiofrequency catheter ablation.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4541653&req=5

Figure 1: Kaplan-Meier curves of AF free survival between patients with and without the rs1799983 variant within 3 months after RFCA of AF. AF, atrial fibrillation; RFCA, radiofrequency catheter ablation.
Mentions: Table 3 summarizes the differences between AF patients with rs1799983 variants and those without variants. There were no significant differences in general clinical features and the degree of LA electro-anatomical remodeling between patients with and without the rs1799983 variant (T). In addition, serum hsCRP levels were not significantly higher in patients with the rs1799983 variant. Interestingly, the frequency of associated stroke/transient ischemic attack and coronary artery disease was significantly higher in patients with the rs1799983 variant (p=0.004). Statin utilization was also significantly higher in patients with the rs1799983 variant (p=0.010). ERAF (within 3 months post-RFCA) was observed in 31.8%, whereas clinical recurrence of AF (after 3 months post-RFCA) occurred in 24.8% of the patients during mean follow-up of 17±8 months. The clinical recurrence rate after 3 month post-RFCA was not different in patients with rs1799983 variant and in those without (p=0.907). However, ERAF was more frequent in patients with the variant allele of the rs1799983 than in those without (42.2% vs. 29.8%, p=0.027). In addition, ERAF occurred significantly earlier in the carriers of the variant allele (mean early recurrence days, 11±16 days vs. 20±25 days, p=0.016) (Fig. 1).

Bottom Line: The rs1799983 variant was associated with higher risk of ERAF (OR 1.71, 95% CI 1.06-2.79, p=0.028), but not with CR.ERAF occurred earlier (11±16 days) in variant group than those without variant allele (20±25 days, p=0.016).The rs1799983 variant of the eNOS3 gene was associated with ERAF, but not with CR, after RFCA. eNOS3 gene variants may have a potential role for stratification of post-ablation management.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Korea University Anam Hospital, Seoul, Korea.

ABSTRACT

Purpose: Previous studies have demonstrated an association between eNOS polymorphisms and atrial fibrillation (AF). We sought to determine whether eNOS polymorphisms are associated with AF recurrence after a radiofrequency catheter ablation (RFCA).

Materials and methods: A total of 500 consecutive patients (56±11 years, 77% male) with paroxysmal (68%) or persistent (32%) AF who underwent RFCA and 500 age, gender-matched controls were genotyped for the eNOS3 single nucleotide polymorphism (rs1799983). AF recurrence was monitored according to 2012 ACC/AHA/ESC guidelines.

Results: The frequencies of the rs1799983 variant alleles (T) in the case and control group were not significantly different (OR 1.05, 95% CI 0.75-1.46, p=0.798). AF patients with rs1799983 variants were more likely to have coronary artery disease or stroke than those without genetic variant at this gene (31.0% vs. 17.3%, p=0.004). During mean 17 months follow-up, early recurrence of AF (ERAF; within 3 months) and clinical recurrence (CR) of AF were 31.8% and 24.8%, respectively. The rs1799983 variant was associated with higher risk of ERAF (OR 1.71, 95% CI 1.06-2.79, p=0.028), but not with CR. ERAF occurred earlier (11±16 days) in variant group than those without variant allele (20±25 days, p=0.016). A multiple logistic regression analysis showed that presence of the rs1799983 variant (OR 1.75, 95% CI 1.07-2.86, p=0.026) and persistent AF were independent predictors for ERAF after AF ablation.

Conclusion: The rs1799983 variant of the eNOS3 gene was associated with ERAF, but not with CR, after RFCA. eNOS3 gene variants may have a potential role for stratification of post-ablation management.

Show MeSH
Related in: MedlinePlus