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Assessment of allergen-induced respiratory hyperresponsiveness before the prescription of a specific immunotherapy.

Olivier CE, Argentão DG, Dos Santos Lima RP, da Silva MD, Dos Santos RA, Fabbri N - Allergy Rhinol (Providence) (2015)

Bottom Line: The differences between the pre- and postspirometric estimated values of peak expiratory flow rate (PEFdif%), forced expiratory volume in 1 second (FEV1dif%), and forced vital capacity (FVCdif%) were correlated with the results of the nasal provocation test symptom score (NPT-SS).There were 119 subjects (69%) with NPT-SS > 2.The Spearman's correlation between PEFdif% and NPT-SS was r = -0.44 (p = 0.01); the Spearman's correlation between FEV1dif% and NPT-SS was r = -0.22 (p = 0.01), and the Spearman's correlation between FVCdif% and NPT-SS was r = -0.21 (p = 0.04).

View Article: PubMed Central - PubMed

Affiliation: Instituto Alergoimuno de Americana, São Paulo, Brazil.

ABSTRACT

Background: Asymptomatic sensitization is a frequent condition that must be considered before the indication of allergic-specific immunotherapy.

Objective: The aim of this study was to appreciate and correlate the local and spirometric changes elicited by the allergen-specific nasal provocation test (NPT) to define practical and feasible guidelines for the allergist/immunologist to demonstrate specific respiratory hyperresponsiveness before the indication of allergic-specific immunotherapy.

Methods: A total of 172 subjects (children and adults) with a diagnosis of allergic rhinitis were submitted to flow-volume spirometry immediately before and after the NPT performed with Dermatophagoides antigens. The differences between the pre- and postspirometric estimated values of peak expiratory flow rate (PEFdif%), forced expiratory volume in 1 second (FEV1dif%), and forced vital capacity (FVCdif%) were correlated with the results of the nasal provocation test symptom score (NPT-SS).

Results: There were 119 subjects (69%) with NPT-SS > 2. Among these patients who were reactive, the mean NPT-SS was 6.3. The Spearman's correlation between PEFdif% and NPT-SS was r = -0.44 (p = 0.01); the Spearman's correlation between FEV1dif% and NPT-SS was r = -0.22 (p = 0.01), and the Spearman's correlation between FVCdif% and NPT-SS was r = -0.21 (p = 0.04).

Conclusion: The combined utilization of the allergen-specific NPT-SS with the spirometry (or PEF meter) is a safe methodology to evaluate allergen-specific nasal and bronchial hyperresponsiveness (which sometimes acts as a bronchial provocation test) in patients with allergic rhinitis and asthma due to hypersensitivity who are candidates for allergen-specific immunotherapy.

No MeSH data available.


Related in: MedlinePlus

A paired correlation chart between the symptom score of the NPT with D. pteronyssinus and the PEF relative decrease after NPT in subjects with allergic rhinitis and a decrease in PEF ≥15%.
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Figure 1: A paired correlation chart between the symptom score of the NPT with D. pteronyssinus and the PEF relative decrease after NPT in subjects with allergic rhinitis and a decrease in PEF ≥15%.

Mentions: There were 12 subjects (7%) who had a decrease of PEF of >20% (PEFdif% = 21–42%; mean PEFdif% = 25.9%). Among these subjects, the mean relative decrease of PEF after NPT (PEFdif%) was 25.9%. There were 33 subjects (19.1%) who had a decrease of PEF of ≥15%. Among these subjects who were reactive, the mean relative decrease of PEF after NPT (PEFdif%) was 20.5%. In this group, the Spearman's correlation between PEFdif% and NPT-SS was r = −0.44 (p = 0.01) (Fig. 1).


Assessment of allergen-induced respiratory hyperresponsiveness before the prescription of a specific immunotherapy.

Olivier CE, Argentão DG, Dos Santos Lima RP, da Silva MD, Dos Santos RA, Fabbri N - Allergy Rhinol (Providence) (2015)

A paired correlation chart between the symptom score of the NPT with D. pteronyssinus and the PEF relative decrease after NPT in subjects with allergic rhinitis and a decrease in PEF ≥15%.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4541640&req=5

Figure 1: A paired correlation chart between the symptom score of the NPT with D. pteronyssinus and the PEF relative decrease after NPT in subjects with allergic rhinitis and a decrease in PEF ≥15%.
Mentions: There were 12 subjects (7%) who had a decrease of PEF of >20% (PEFdif% = 21–42%; mean PEFdif% = 25.9%). Among these subjects, the mean relative decrease of PEF after NPT (PEFdif%) was 25.9%. There were 33 subjects (19.1%) who had a decrease of PEF of ≥15%. Among these subjects who were reactive, the mean relative decrease of PEF after NPT (PEFdif%) was 20.5%. In this group, the Spearman's correlation between PEFdif% and NPT-SS was r = −0.44 (p = 0.01) (Fig. 1).

Bottom Line: The differences between the pre- and postspirometric estimated values of peak expiratory flow rate (PEFdif%), forced expiratory volume in 1 second (FEV1dif%), and forced vital capacity (FVCdif%) were correlated with the results of the nasal provocation test symptom score (NPT-SS).There were 119 subjects (69%) with NPT-SS > 2.The Spearman's correlation between PEFdif% and NPT-SS was r = -0.44 (p = 0.01); the Spearman's correlation between FEV1dif% and NPT-SS was r = -0.22 (p = 0.01), and the Spearman's correlation between FVCdif% and NPT-SS was r = -0.21 (p = 0.04).

View Article: PubMed Central - PubMed

Affiliation: Instituto Alergoimuno de Americana, São Paulo, Brazil.

ABSTRACT

Background: Asymptomatic sensitization is a frequent condition that must be considered before the indication of allergic-specific immunotherapy.

Objective: The aim of this study was to appreciate and correlate the local and spirometric changes elicited by the allergen-specific nasal provocation test (NPT) to define practical and feasible guidelines for the allergist/immunologist to demonstrate specific respiratory hyperresponsiveness before the indication of allergic-specific immunotherapy.

Methods: A total of 172 subjects (children and adults) with a diagnosis of allergic rhinitis were submitted to flow-volume spirometry immediately before and after the NPT performed with Dermatophagoides antigens. The differences between the pre- and postspirometric estimated values of peak expiratory flow rate (PEFdif%), forced expiratory volume in 1 second (FEV1dif%), and forced vital capacity (FVCdif%) were correlated with the results of the nasal provocation test symptom score (NPT-SS).

Results: There were 119 subjects (69%) with NPT-SS > 2. Among these patients who were reactive, the mean NPT-SS was 6.3. The Spearman's correlation between PEFdif% and NPT-SS was r = -0.44 (p = 0.01); the Spearman's correlation between FEV1dif% and NPT-SS was r = -0.22 (p = 0.01), and the Spearman's correlation between FVCdif% and NPT-SS was r = -0.21 (p = 0.04).

Conclusion: The combined utilization of the allergen-specific NPT-SS with the spirometry (or PEF meter) is a safe methodology to evaluate allergen-specific nasal and bronchial hyperresponsiveness (which sometimes acts as a bronchial provocation test) in patients with allergic rhinitis and asthma due to hypersensitivity who are candidates for allergen-specific immunotherapy.

No MeSH data available.


Related in: MedlinePlus